open access

Vol 88, No 8 (2017)
Review paper
Published online: 2017-08-31
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Efficacy and safety of blood transfusion in obstetric patients: systematic review of the literature

Celso Módolo, Arnav Agarwal, Mariana Floriano Luiza Piva, Andresa Graciutti Botan, Samira Esteves Afonso Camargo, Nermeen Gawish, Norma Sueli Pinheiro Módolo, Regina El Dib
DOI: 10.5603/GP.a2017.0082
·
Pubmed: 28930372
·
Ginekol Pol 2017;88(8):446-452.

open access

Vol 88, No 8 (2017)
REVIEW PAPERS Obstetrics
Published online: 2017-08-31

Abstract

Objectives: To evaluate the efficacy of blood transfusion compared to no intervention in obstetric patients. Material and methods: A systematic review was performed with Cochrane Database of Clinical Trials, PubMed, EMBASE and LILACS databases searched as of September, 2016. Two authors independently selected relevant clinical trials, assessed their methodological quality and extracted data, using the GRADE approach.

Results: Five studies within a total of 6,297 met the inclusion criteria, with women generally aged 20–40 years. Three included studies allocated women to receive blood transfusion or no intervention. Two other studies allocated women with either restricted or full blood supplies. The major issue regarding risk of bias was the extent of concealment of randomization and blinding. There was no statistically significant difference between blood transfusion versus no transfusion or restricted blood supply on mortality (relative risk 0.82 [95% confidential interval 0.32 to 2.09], p = 0.68; two studies; I2 = not applicable). Conclusions: Very low-quality evidence suggests no significant difference between blood transfusion and no intervention in obstetric patients, underlining the need for more robust clinical trials evaluating this area.

Abstract

Objectives: To evaluate the efficacy of blood transfusion compared to no intervention in obstetric patients. Material and methods: A systematic review was performed with Cochrane Database of Clinical Trials, PubMed, EMBASE and LILACS databases searched as of September, 2016. Two authors independently selected relevant clinical trials, assessed their methodological quality and extracted data, using the GRADE approach.

Results: Five studies within a total of 6,297 met the inclusion criteria, with women generally aged 20–40 years. Three included studies allocated women to receive blood transfusion or no intervention. Two other studies allocated women with either restricted or full blood supplies. The major issue regarding risk of bias was the extent of concealment of randomization and blinding. There was no statistically significant difference between blood transfusion versus no transfusion or restricted blood supply on mortality (relative risk 0.82 [95% confidential interval 0.32 to 2.09], p = 0.68; two studies; I2 = not applicable). Conclusions: Very low-quality evidence suggests no significant difference between blood transfusion and no intervention in obstetric patients, underlining the need for more robust clinical trials evaluating this area.

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Keywords

blood transfusion, obstetric labor, systematic review, randomized controlled clinical trials

About this article
Title

Efficacy and safety of blood transfusion in obstetric patients: systematic review of the literature

Journal

Ginekologia Polska

Issue

Vol 88, No 8 (2017)

Article type

Review paper

Pages

446-452

Published online

2017-08-31

DOI

10.5603/GP.a2017.0082

Pubmed

28930372

Bibliographic record

Ginekol Pol 2017;88(8):446-452.

Keywords

blood transfusion
obstetric labor
systematic review
randomized controlled clinical trials

Authors

Celso Módolo
Arnav Agarwal
Mariana Floriano Luiza Piva
Andresa Graciutti Botan
Samira Esteves Afonso Camargo
Nermeen Gawish
Norma Sueli Pinheiro Módolo
Regina El Dib

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