open access

Vol 88, No 5 (2017)
Research paper
Published online: 2017-05-31
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IL16 and IL18 gene polymorphisms in women with gestational diabetes

Maciej Tarnowski1, Alicja Wieczorek2, Violetta Dziedziejko3, Krzysztof Safranow3, Przemysław Ustianowski4, Zbigniew Celewicz4, Andrzej Pawlik1
DOI: 10.5603/GP.a2017.0047
·
Pubmed: 28580570
·
Ginekol Pol 2017;88(5):249-254.
Affiliations
  1. Department of Physiology, Pomeranian Medical University, Szczecin, Poland 2”For-Dent” Medical Center, Pyrzyce, Poland, Poland
  2. ”For-Dent” Medical Center, Pyrzyce, Poland, Poland
  3. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  4. Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland

open access

Vol 88, No 5 (2017)
ORIGINAL PAPERS Obstetrics
Published online: 2017-05-31

Abstract

Objectives: Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between IL16 and IL18 polymorphisms and GDM.

Material and methods: This study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). All samples were genotyped in duplicate using allelic discrimination assays with TaqMan® probes.

Results: We observed that there was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with GDM (CC vs. CT + TT: OR = 0.14; 95% CI = 0.02–1.15; p = 0.034). However, there was no significant difference in the distri­bution of alleles (C vs. T: OR = 0.81; 95% CI = 0.54–1.21; p = 0.30). There was a decreased frequency of the IL18 rs187238 G allele among GDM women (G vs. C: OR = 0.71; 95% CI = 0.53–0.96; p = 0.027). We also observed a decreased frequency of the IL18 rs1946518 T allele among women with GDM; however, this difference had only borderline statistical significance. We observed an association between IL18 rs187238, rs1946518 and BMI in pregnant women.

Conclusions: The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of GDM as well as with BMI in pregnant women.

Abstract

Objectives: Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between IL16 and IL18 polymorphisms and GDM.

Material and methods: This study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). All samples were genotyped in duplicate using allelic discrimination assays with TaqMan® probes.

Results: We observed that there was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with GDM (CC vs. CT + TT: OR = 0.14; 95% CI = 0.02–1.15; p = 0.034). However, there was no significant difference in the distri­bution of alleles (C vs. T: OR = 0.81; 95% CI = 0.54–1.21; p = 0.30). There was a decreased frequency of the IL18 rs187238 G allele among GDM women (G vs. C: OR = 0.71; 95% CI = 0.53–0.96; p = 0.027). We also observed a decreased frequency of the IL18 rs1946518 T allele among women with GDM; however, this difference had only borderline statistical significance. We observed an association between IL18 rs187238, rs1946518 and BMI in pregnant women.

Conclusions: The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of GDM as well as with BMI in pregnant women.

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Keywords

polymorphism, SNP, gestational diabetes, genes, metabolism

About this article
Title

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Journal

Ginekologia Polska

Issue

Vol 88, No 5 (2017)

Article type

Research paper

Pages

249-254

Published online

2017-05-31

DOI

10.5603/GP.a2017.0047

Pubmed

28580570

Bibliographic record

Ginekol Pol 2017;88(5):249-254.

Keywords

polymorphism
SNP
gestational diabetes
genes
metabolism

Authors

Maciej Tarnowski
Alicja Wieczorek
Violetta Dziedziejko
Krzysztof Safranow
Przemysław Ustianowski
Zbigniew Celewicz
Andrzej Pawlik

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