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The role of metalloproteinases in endometrial remodelling during menstrual cycle
Affiliations- Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Medical University of Warsaw, Poland, Poland
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Abstract
Endometrium is the only tissue in the human body subject to cyclic transformations under the influence of ovarian steroid hormones. As estradiol and progesterone balance throughout the physiological menstrual cycle changes, so does the expression of metalloproteinases (MMPs). These endopeptides are responsible for keeping the balance between the process of synthesis and degradation of extracellular matrix proteins. Thus, MMP’s take part in sustaining physiological stability of the endometrium. A number of MMPs found in the endometrial tissue and their activity is related to menstrual cycle phase. This paper is an up-to-date review of literature of Medline database. The search was conducted for key words including “matrix metalloproteinases”, “MMPs”, “TIMPs” and “tissue inhibitors of metalloproteinases”. Over 1092 publications regarding interdependence and interplay between ovarian hormones and the role of various MMPs and their inhibitors in normal endometrial remodelling and in pathological conditions were analysed and critically reviewed.
Abstract
Endometrium is the only tissue in the human body subject to cyclic transformations under the influence of ovarian steroid hormones. As estradiol and progesterone balance throughout the physiological menstrual cycle changes, so does the expression of metalloproteinases (MMPs). These endopeptides are responsible for keeping the balance between the process of synthesis and degradation of extracellular matrix proteins. Thus, MMP’s take part in sustaining physiological stability of the endometrium. A number of MMPs found in the endometrial tissue and their activity is related to menstrual cycle phase. This paper is an up-to-date review of literature of Medline database. The search was conducted for key words including “matrix metalloproteinases”, “MMPs”, “TIMPs” and “tissue inhibitors of metalloproteinases”. Over 1092 publications regarding interdependence and interplay between ovarian hormones and the role of various MMPs and their inhibitors in normal endometrial remodelling and in pathological conditions were analysed and critically reviewed.
Keywords
extracellular matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), endometrium, bleeding
About this articleTitle
The role of metalloproteinases in endometrial remodelling during menstrual cycle
Journal
Issue
Article type
Review paper
Pages
337-342
Published online
2017-06-30
Page views
2323
Article views/downloads
3108
DOI
Pubmed
Bibliographic record
Ginekol Pol 2017;88(6):337-342.
Keywords
extracellular matrix metalloproteinases (MMPs)
tissue inhibitors of metalloproteinases (TIMPs)
endometrium
bleeding
Authors
Barbara Grzechocińska
Filip Dąbrowski
Anna Cyganek
Grzegorz Panek
Mirosław Wielgoś
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