open access

Vol 87, No 9 (2016)
Research paper
Published online: 2016-09-30
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The application of CYFRA21-1 in cervical lesions screening in high-risk human papillomavirus infected women

Feng Yang-chun, Yang Jia, Huang Yan-chun
DOI: 10.5603/GP.2016.0055
·
Pubmed: 27723067
·
Ginekol Pol 2016;87(9):617-620.

open access

Vol 87, No 9 (2016)
ORIGINAL PAPERS Gynecology
Published online: 2016-09-30

Abstract

Objectives: To investigate the role of cytokeratin-19 fragment (CYFRA21-1) in cervical lesions screening in high-risk hu­man papillomavirus (HR-HPV) infected women.

Material and methods: The study was a retrospective study. First, the results of CYFRA21-1, cytology (TCT), and HR-HPV examinations of 1039 outpatients from gynecology department in Tumor Hospital Affiliated to Xinjiang Medical University were collected. Then, the data was analyzed using a series of statistical methods.

Results: There was a correlation between CYFRA21-1 levels and HPV-DNA load in HR-HPV infected women (rs = 0.711, p = 0.015). CYFRA21-1 levels and positive rate increased along with deepening of cervical cell lesions. In HR-HPV infected women, there was a statistically significant difference (t = 6.022, p < 0.001) in CYFRA21-1 levels between the group with cytological lesions (4.87 ± 1.58 ng/mL) and the group with normal cytology (2.52 ± 0.96 ng/mL). Positive rates of CYFRA21-1 in the two groups were 62.06% and 7.83%, respectively, and also exhibited statistically significant differences (χ2 = 74.624, p < 0.001). When diagnosing cytological lesions via CYFRA21-1 in HR-HPV infected women, sensitivity was 62.07%, specificity was 92.17%, positive predictive value was 88.89%,negative predictive value was 70.67%. Compared to CYFRA21-1 negative women, cytological lesions were detected 19.273 times more often in CYFRA21-1 positive women.

Conclusion: CYFRA21-1 could provide a reference idea for further diagnosis of women who are infected with HR-HPV but whose cytology is normal.

Abstract

Objectives: To investigate the role of cytokeratin-19 fragment (CYFRA21-1) in cervical lesions screening in high-risk hu­man papillomavirus (HR-HPV) infected women.

Material and methods: The study was a retrospective study. First, the results of CYFRA21-1, cytology (TCT), and HR-HPV examinations of 1039 outpatients from gynecology department in Tumor Hospital Affiliated to Xinjiang Medical University were collected. Then, the data was analyzed using a series of statistical methods.

Results: There was a correlation between CYFRA21-1 levels and HPV-DNA load in HR-HPV infected women (rs = 0.711, p = 0.015). CYFRA21-1 levels and positive rate increased along with deepening of cervical cell lesions. In HR-HPV infected women, there was a statistically significant difference (t = 6.022, p < 0.001) in CYFRA21-1 levels between the group with cytological lesions (4.87 ± 1.58 ng/mL) and the group with normal cytology (2.52 ± 0.96 ng/mL). Positive rates of CYFRA21-1 in the two groups were 62.06% and 7.83%, respectively, and also exhibited statistically significant differences (χ2 = 74.624, p < 0.001). When diagnosing cytological lesions via CYFRA21-1 in HR-HPV infected women, sensitivity was 62.07%, specificity was 92.17%, positive predictive value was 88.89%,negative predictive value was 70.67%. Compared to CYFRA21-1 negative women, cytological lesions were detected 19.273 times more often in CYFRA21-1 positive women.

Conclusion: CYFRA21-1 could provide a reference idea for further diagnosis of women who are infected with HR-HPV but whose cytology is normal.

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Keywords

high-risk, human papillomavirus, CYFRA21-1, cervical lesions

About this article
Title

The application of CYFRA21-1 in cervical lesions screening in high-risk human papillomavirus infected women

Journal

Ginekologia Polska

Issue

Vol 87, No 9 (2016)

Article type

Research paper

Pages

617-620

Published online

2016-09-30

DOI

10.5603/GP.2016.0055

Pubmed

27723067

Bibliographic record

Ginekol Pol 2016;87(9):617-620.

Keywords

high-risk
human papillomavirus
CYFRA21-1
cervical lesions

Authors

Feng Yang-chun
Yang Jia
Huang Yan-chun

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