open access

Vol 87, No 9 (2016)
Research paper
Published online: 2016-09-30
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First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy

Filip A. Dąbrowski, Patrycja Jarmużek, Agata Gondek, Agnieszka Cudnoch-Jędrzejewska, Dorota Bomba-Opoń, Mirosław Wielgoś
DOI: 10.5603/GP.2016.0057
·
Pubmed: 27723069
·
Ginekol Pol 2016;87(9):629-634.

open access

Vol 87, No 9 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-09-30

Abstract

Objectives: Gestational diabetes mellitus (GDM) is a metabolic disease diagnosed in 1.7% up to 11.6% pregnancies. The prevalence of adverse pregnancy outcome is significantly higher in the case of early onset of diabetes mellitus. Adropin is a hormone promoting carbohydrate oxidation over fat oxidation, and influence nitric oxide synthase. Copeptin is a cleavage product of the vasopressin precursor recently correlated with diabetes mellitus. The aim of the study was to determine maternal serum adropin and copeptin concentrations in women with early and late manifestation of GDM and to discuss their potential role as biochemical markers of insulin resistance.

Material and methods: Case-control study on 58 pregnant Caucasian women. Serum levels of adropin and copeptin were assessed in patients with early onset (GDM1) and classical gestational diabetes mellitus (GDM2). Complications such as macrosomia and hypotrophy were evaluated.

Results: There was no significant difference between the study and the control group (age, BMI, parity). Fetal growth disturbance rate was 37.5% in GDM1, 11% in GDM2 and 6% in controls. Adropin concentration in GDM patients was significantly higher than in control group (p < 0.001), but there was no difference between GDM1 and GDM2 group. High serum concentration of adropin positively correlated with elevated HbA1c (p < 0.05). The groups did not differ in terms of copeptin serum concentration.

Conclusions: High adropin serum concentration in GDM patients is associated with increased risk of fetal growth disturbances, possibly due to improper placentation. According to our prospective study, neither copeptin nor adropin serum concentration are useful to discriminate between early and late onset of gestational diabetes mellitus.

Abstract

Objectives: Gestational diabetes mellitus (GDM) is a metabolic disease diagnosed in 1.7% up to 11.6% pregnancies. The prevalence of adverse pregnancy outcome is significantly higher in the case of early onset of diabetes mellitus. Adropin is a hormone promoting carbohydrate oxidation over fat oxidation, and influence nitric oxide synthase. Copeptin is a cleavage product of the vasopressin precursor recently correlated with diabetes mellitus. The aim of the study was to determine maternal serum adropin and copeptin concentrations in women with early and late manifestation of GDM and to discuss their potential role as biochemical markers of insulin resistance.

Material and methods: Case-control study on 58 pregnant Caucasian women. Serum levels of adropin and copeptin were assessed in patients with early onset (GDM1) and classical gestational diabetes mellitus (GDM2). Complications such as macrosomia and hypotrophy were evaluated.

Results: There was no significant difference between the study and the control group (age, BMI, parity). Fetal growth disturbance rate was 37.5% in GDM1, 11% in GDM2 and 6% in controls. Adropin concentration in GDM patients was significantly higher than in control group (p < 0.001), but there was no difference between GDM1 and GDM2 group. High serum concentration of adropin positively correlated with elevated HbA1c (p < 0.05). The groups did not differ in terms of copeptin serum concentration.

Conclusions: High adropin serum concentration in GDM patients is associated with increased risk of fetal growth disturbances, possibly due to improper placentation. According to our prospective study, neither copeptin nor adropin serum concentration are useful to discriminate between early and late onset of gestational diabetes mellitus.

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Keywords

pregnancy, diabetes mellitus, gestational diabetes mellitus, adropin, copeptin

About this article
Title

First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy

Journal

Ginekologia Polska

Issue

Vol 87, No 9 (2016)

Article type

Research paper

Pages

629-634

Published online

2016-09-30

DOI

10.5603/GP.2016.0057

Pubmed

27723069

Bibliographic record

Ginekol Pol 2016;87(9):629-634.

Keywords

pregnancy
diabetes mellitus
gestational diabetes mellitus
adropin
copeptin

Authors

Filip A. Dąbrowski
Patrycja Jarmużek
Agata Gondek
Agnieszka Cudnoch-Jędrzejewska
Dorota Bomba-Opoń
Mirosław Wielgoś

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