Vol 88, No 2 (2017)
Research paper
Published online: 2017-02-28

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Complete response to acupuncture therapy in female patients with refractory interstitial cystitis/bladder pain syndrome

Mehmet Giray Sönmez, Betül Kozanhan
Pubmed: 28326514
Ginekol Pol 2017;88(2):61-67.


Objectives: Interstitial Cystitis/Bladder Pain syndrome (IC/BPS) is a considerable issue in urology and gynecology and unfortunately, the treatment options recommended are not fully efficient. Therefore, in this study we aimed to determine the effectiveness of acupuncture treatment in patients with refractory IC/BPS.

Material and methods: 12 refractory IC/BPS female patients received ten sessions of acupuncture twice a week. The visual analog score (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), O’Leary-Saint symptom score (OSS), Patient Health Questionnaire (PHQ9), Pelvic pain and urgency & frequency patient symptom scale tests (PUF) and maximum voided volume (MVV) was completed in 1st, 3rd, 6th and 12th months following the treatment.

Results: There was a statistically significant decrease in all of the scores evaluated at first month compared with the baseline. While the change in VAS score in 1, 3, 6 and 12th months were found statistically significant, measurements of ICSI, OSS and PUF scores and MVV values in the 6th and 12th months and ICPI and PHQ scores in the 12th month were not found statistically significant compared to the pre-treatment period. Response to treatment for the first three months after acupuncture application was (100%), but this ratio was measured as 33.3% (4/12) in the sixth month and 16.6% in the 12th month (2/12).

Conclusions: The results of this study suggest that acupuncture appears to be an effective, useful, non-invasive method in IC/BPS patients. It can be used as an appropriate treatment method not only in refractory but also in IC patients since it is rather advantageous compared to other treating agents.


  1. Engeler D, Baranowski AP, Borovicka J. et.al. European Association of Urology Guidelines on Chronic Pelvic Pain. 2015: 23-31
  2. Bosch PC, Bosch DC. Treating interstitial cystitis/bladder pain syndrome as a chronic disease. Rev Urol. 2014; 16(2): 83–87.
  3. Gülpınar O, Kayış A, Süer E, et al. Clinical comparision of intravesical hyaluronic acid and hyaluronic acid-chondroitin sulphate therapy for patients with bladder pain syndrome/interstitital cystitis. Can Urol Assoc J. 2014; 8(9-10): E610–E614.
  4. Hung MJ, Su TH, Lin YH, et al. Changes in sexual function of women with refractory interstitial cystitis/bladder pain syndrome after intravesical therapy with a hyaluronic acid solution. J Sex Med. 2014; 11(9): 2256–2263.
  5. Lee CL, Kuo HC. Long-Term Efficacy and Safety of Repeated Intravescial OnabotulinumtoxinA Injections Plus Hydrodistention in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome. Toxins (Basel). 2015; 7(10): 4283–4293.
  6. Kuo HC, Jiang YH, Tsai YC, et al. Intravesical botulinum toxin-A injections reduce bladder pain of interstitial cystitis/bladder pain syndrome refractory to conventional treatment - A prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. Neurourol Urodyn. 2016; 35(5): 609–614.
  7. Engelhardt PF, Morakis N, Daha LK, et al. Long-term results of intravesical hyaluronan therapy in bladder pain syndrome/interstitial cystitis. Int Urogynecol J. 2011; 22(4): 401–405.
  8. Robinson R. The economic burden of interstitial cystitis and painful bladder syndrome. J Urol 185(4S): e129.
  9. Cabıoğlu MT, Ergene N. The effect mechanism of acupuncture and clinical applications. Genel Tıp Derg 2003; 13(1): 35-40.
  10. Guyton AC, Hall JE. Textbook of medical physiology. Philadelphia, WB Saunders. ; 2001.
  11. Tugcu V, Tas S, Eren G, et al. Effectiveness of acupuncture in patients with category IIIB chronic pelvic pain syndrome: a report of 97 patients. Pain Med. 2010; 11(4): 518–523.
  12. Lee SH, Lee BC. Electroacupuncture relieves pain in men with chronic prostatitis/chronic pelvic pain syndrome: three-arm randomized trial. Urology. 2009; 73(5): 1036–1041.
  13. Li J, Han CH, Cheng XH, et al. [Observation on therapeutic effects of elongated needle therapy on dysuria induced by benign prostatic hyperplasia]. Zhongguo Zhen Jiu. 2008; 28(10): 707–709.
  14. Kelleher C, Filshie J, Burton G, et al. Acupuncture and the treatment of irritative bladder symptoms. Acupuncture in Medicine. 1994; 12(1): 9–12.
  15. Tempest H, Reynard J, Bryant RJ, et al. Acupuncture in urological practice--a survey of urologists in England. Complement Ther Med. 2011; 19(1): 27–31.
  16. Geirsson G, Wang YH, Lindström S, et al. Traditional acupuncture and electrical stimulation of the posterior tibial nerve. A trial in chronic interstitial cystitis. Scand J Urol Nephrol. 1993; 27(1): 67–70.
  17. Katayama Y, Nakahara K, Shitamura T, et al. [Effectiveness of acupuncture and moxibustion therapy for the treatment of refractory interstitial cystitis]. Hinyokika Kiyo. 2013; 59(5): 265–269.
  18. Wewers ME, Lowe NK. A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health. 1990; 13(4): 227–236.
  19. O'Leary MP, Sant GR, Fowler FJ, et al. The interstitial cystitis symptom index and problem index. Urology. 1997; 49(5A Suppl): 58–63.
  20. Löwe B, Kroenke K, Herzog W, et al. Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9). J Affect Disord. 2004; 81(1): 61–66.
  21. Parsons C, Dell J, Stanford E, et al. Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity. Urology. 2002; 60(4): 573–578.
  22. Hanno PM, Burks DA, Clemens JQ, et al. Interstitial Cystitis Guidelines Panel of the American Urological Association Education and Research, Inc. AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. J Urol. 2011; 185(6): 2162–2170.
  23. Chancellor MB. A Multidisciplinary Consensus Meeting on IC/PBS: Outcome of the Consensus Meeting on Interstitial Cystitis/Painful Bladder Syndrome, February 10, 2007, Washington, DC. Rev Urol. 2007; 9(2): 81–83.
  24. Honjo H, Kamoi K, Naya Y, et al. Effects of acupuncture for chronic pelvic pain syndrome with intrapelvic venous congestion: preliminary results. Int J Urol. 2004; 11(8): 607–612.
  25. Sung L, Jiaqi W. Acupuncture for urinary incontinence in adults without neurological disease. Cochrane Database of Systematic Reviews. 2006.
  26. Liu Z, Liu B, Yang T, et.al. Clinical study of electroacupuncture treatment of senile urge urinary incontinence. Int J Clin Acupunct 2002; 13(4): 255–262.
  27. Emmons SL, Otto L. Acupuncture for overactive bladder: a randomized controlled trial. Obstet Gynecol. 2005; 106(1): 138–143.
  28. Napadow V, Lee J, Kim J, et al. Brain correlates of phasic autonomic response to acupuncture stimulation: an event-related fMRI study. Hum Brain Mapp. 2013; 34(10): 2592–2606.
  29. Wang H, Tanaka Y, Kawauchi A, et al. Acupuncture of the sacral vertebrae suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center. Neurosci Res. 2012; 72(1): 43–49.
  30. Hino K, Honjo H, Nakao M, et al. The effects of sacral acupuncture on acetic acid-induced bladder irritation in conscious rats. Urology. 2010; 75(3): 730–734.