open access

Vol 87, No 6 (2016)
Review paper
Published online: 2016-06-30
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Opportunistic salpingectomy for prevention of sporadic ovarian cancer — a jump from basic science to clinical practice?

Alicja Ziętek, Michał Bogusiewicz, Justyna Szumiło, Tomasz Rechberger
DOI: 10.5603/GP.2016.0027
·
Pubmed: 27418226
·
Ginekol Pol 2016;87(6):467-472.

open access

Vol 87, No 6 (2016)
REVIEW PAPERS Gynecology
Published online: 2016-06-30

Abstract

Ovarian cancer is the most malignant and aggressive gynecological cancer. Due to nonspecific symptoms in the early stage and a lack of effective screening methods, it is typically diagnosed at an advanced stage. The high-grade serous cancer (HGSC) represents 75% of all ovarian cancers and accounts for the majority of deaths. Contemporary thought suggests that precursor lesions of HGSC originate in the fallopian tube. The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma (STIC). Thus, removal of the fallopian tubes at the time of pelvic or abdominal surgery for a benign condition (i.e. opportunistic salpingectomy) appears as an attractive option for primary prevention of HGSC. This paper presents the scientific background of opportunistic salpingectomy and discusses controversies regarding the benefits and safety of the procedure.

Abstract

Ovarian cancer is the most malignant and aggressive gynecological cancer. Due to nonspecific symptoms in the early stage and a lack of effective screening methods, it is typically diagnosed at an advanced stage. The high-grade serous cancer (HGSC) represents 75% of all ovarian cancers and accounts for the majority of deaths. Contemporary thought suggests that precursor lesions of HGSC originate in the fallopian tube. The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma (STIC). Thus, removal of the fallopian tubes at the time of pelvic or abdominal surgery for a benign condition (i.e. opportunistic salpingectomy) appears as an attractive option for primary prevention of HGSC. This paper presents the scientific background of opportunistic salpingectomy and discusses controversies regarding the benefits and safety of the procedure.

Get Citation

Keywords

fallopian tubes, ovary neoplasms, salpingectomy

About this article
Title

Opportunistic salpingectomy for prevention of sporadic ovarian cancer — a jump from basic science to clinical practice?

Journal

Ginekologia Polska

Issue

Vol 87, No 6 (2016)

Article type

Review paper

Pages

467-472

Published online

2016-06-30

DOI

10.5603/GP.2016.0027

Pubmed

27418226

Bibliographic record

Ginekol Pol 2016;87(6):467-472.

Keywords

fallopian tubes
ovary neoplasms
salpingectomy

Authors

Alicja Ziętek
Michał Bogusiewicz
Justyna Szumiło
Tomasz Rechberger

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