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Opportunistic salpingectomy for prevention of sporadic ovarian cancer — a jump from basic science to clinical practice?
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Abstract
Ovarian cancer is the most malignant and aggressive gynecological cancer. Due to nonspecific symptoms in the early stage and a lack of effective screening methods, it is typically diagnosed at an advanced stage. The high-grade serous cancer (HGSC) represents 75% of all ovarian cancers and accounts for the majority of deaths. Contemporary thought suggests that precursor lesions of HGSC originate in the fallopian tube. The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma (STIC). Thus, removal of the fallopian tubes at the time of pelvic or abdominal surgery for a benign condition (i.e. opportunistic salpingectomy) appears as an attractive option for primary prevention of HGSC. This paper presents the scientific background of opportunistic salpingectomy and discusses controversies regarding the benefits and safety of the procedure.
Abstract
Ovarian cancer is the most malignant and aggressive gynecological cancer. Due to nonspecific symptoms in the early stage and a lack of effective screening methods, it is typically diagnosed at an advanced stage. The high-grade serous cancer (HGSC) represents 75% of all ovarian cancers and accounts for the majority of deaths. Contemporary thought suggests that precursor lesions of HGSC originate in the fallopian tube. The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma (STIC). Thus, removal of the fallopian tubes at the time of pelvic or abdominal surgery for a benign condition (i.e. opportunistic salpingectomy) appears as an attractive option for primary prevention of HGSC. This paper presents the scientific background of opportunistic salpingectomy and discusses controversies regarding the benefits and safety of the procedure.
Keywords
fallopian tubes, ovary neoplasms, salpingectomy
About this articleTitle
Opportunistic salpingectomy for prevention of sporadic ovarian cancer — a jump from basic science to clinical practice?
Journal
Issue
Article type
Review paper
Pages
467-472
Published online
2016-06-30
Page views
1697
Article views/downloads
1992
DOI
10.5603/GP.2016.0027
Pubmed
Bibliographic record
Ginekol Pol 2016;87(6):467-472.
Keywords
fallopian tubes
ovary neoplasms
salpingectomy
Authors
Alicja Ziętek
Michał Bogusiewicz
Justyna Szumiło
Tomasz Rechberger
