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Fetal-maternal complications and their association with gestational thrombocytopenia
open access
Abstract
Objectives: Thrombocytopenia is defined as a platelet count of < 150 × 109/L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate the incidence of perinatal complications in pregnancies complicated with gestational thrombocytopenia and to determine if the severity of maternal gestational thrombocytopenia implicates unfavorable perinatal outcome.
Material and methods: Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50–100 × 109/L — classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 109/L — classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared.
Results: Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01).
Conclusions: Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy.
Abstract
Objectives: Thrombocytopenia is defined as a platelet count of < 150 × 109/L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate the incidence of perinatal complications in pregnancies complicated with gestational thrombocytopenia and to determine if the severity of maternal gestational thrombocytopenia implicates unfavorable perinatal outcome.
Material and methods: Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50–100 × 109/L — classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 109/L — classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared.
Results: Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01).
Conclusions: Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy.
Keywords
gestational thrombocytopenia, neonatal thrombocytopenia, perinatal outcome, platelet count
About this articleTitle
Fetal-maternal complications and their association with gestational thrombocytopenia
Journal
Issue
Article type
Research paper
Pages
454-459
Published online
2016-06-30
Page views
1707
Article views/downloads
2582
DOI
10.5603/GP.2016.0025
Pubmed
Bibliographic record
Ginekol Pol 2016;87(6):454-459.
Keywords
gestational thrombocytopenia
neonatal thrombocytopenia
perinatal outcome
platelet count
Authors
Vesna Elveđi-Gašparović
Petrana Beljan
Snježana Gverić-Ahmetašević
Snježana Schuster
Snježana Škrablin
