open access

Vol 88, No 3 (2017)
Research paper
Published online: 2017-03-31
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Relationship between maternal blood ceruloplasmin level, catalase and myeloperoxidase activity and neural tube defects

Orkun Cetin, Erbil Karaman, Baris Boza, Numan Cim, Murat Alisik, Ozcan Erel, Ismet Alkis, Recep Yildizhan, Ali Kolusari, Guler Hanım Sahin
DOI: 10.5603/GP.a2017.0030
·
Pubmed: 28397206
·
Ginekol Pol 2017;88(3):156-160.

open access

Vol 88, No 3 (2017)
ORIGINAL PAPERS Obstetrics
Published online: 2017-03-31

Abstract

Objectives: The exact pathogenesis of neural tube defects (NTDs) is poorly understood. We aimed at evaluating maternal anti-oxidant capacity (ceruloplasmin level, myeloperoxidase and catalase activity) in pregnancies complicated by NTDs.

Material and methods: Fifty-four mothers with NTD-affected pregnancies and 61 healthy mothers, matched for gestational age, were recruited. Maternal venous blood samples were obtained after detailed fetal ultrasound examination to measure myeloperoxidase, catalase activity and ceruloplasmin levels. The clinical characteristics of all participants were collected.

Results: Maternal blood catalase activity was significantly lower in the study group (117.1 ± 64.8 kU/L) as compared to controls (152.2 ± 110.6 kU/L) (p = 0.044). Maternal blood ceruloplasmin levels were also significantly lower in the study group (180.5 ± 37.7 U/L) as compared to controls (197.9 ± 35.9 U/L) (p = 0.012). Myeloperoxidase activity was similar in both groups (112.6 ± 22.2 U/L vs. 113.6 ± 38.1 U/L) (p = 0.869).

Conclusions: In the present study, maternal blood ceruloplasmin level and catalase activity were found to be lower in NTD-affected pregnancies as compared to healthy controls. Thus, it seems safe to conclude that impaired antioxidant capacity may play a role in the development of NTDs during pregnancy, in addition to the genetic, environmental and metabolic factors.

Abstract

Objectives: The exact pathogenesis of neural tube defects (NTDs) is poorly understood. We aimed at evaluating maternal anti-oxidant capacity (ceruloplasmin level, myeloperoxidase and catalase activity) in pregnancies complicated by NTDs.

Material and methods: Fifty-four mothers with NTD-affected pregnancies and 61 healthy mothers, matched for gestational age, were recruited. Maternal venous blood samples were obtained after detailed fetal ultrasound examination to measure myeloperoxidase, catalase activity and ceruloplasmin levels. The clinical characteristics of all participants were collected.

Results: Maternal blood catalase activity was significantly lower in the study group (117.1 ± 64.8 kU/L) as compared to controls (152.2 ± 110.6 kU/L) (p = 0.044). Maternal blood ceruloplasmin levels were also significantly lower in the study group (180.5 ± 37.7 U/L) as compared to controls (197.9 ± 35.9 U/L) (p = 0.012). Myeloperoxidase activity was similar in both groups (112.6 ± 22.2 U/L vs. 113.6 ± 38.1 U/L) (p = 0.869).

Conclusions: In the present study, maternal blood ceruloplasmin level and catalase activity were found to be lower in NTD-affected pregnancies as compared to healthy controls. Thus, it seems safe to conclude that impaired antioxidant capacity may play a role in the development of NTDs during pregnancy, in addition to the genetic, environmental and metabolic factors.

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Keywords

pregnancy, neural tube defects, catalase, myeloperoxidase, ceruloplasmin

About this article
Title

Relationship between maternal blood ceruloplasmin level, catalase and myeloperoxidase activity and neural tube defects

Journal

Ginekologia Polska

Issue

Vol 88, No 3 (2017)

Article type

Research paper

Pages

156-160

Published online

2017-03-31

DOI

10.5603/GP.a2017.0030

Pubmed

28397206

Bibliographic record

Ginekol Pol 2017;88(3):156-160.

Keywords

pregnancy
neural tube defects
catalase
myeloperoxidase
ceruloplasmin

Authors

Orkun Cetin
Erbil Karaman
Baris Boza
Numan Cim
Murat Alisik
Ozcan Erel
Ismet Alkis
Recep Yildizhan
Ali Kolusari
Guler Hanım Sahin

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