open access

Vol 87, No 5 (2016)
Research paper
Published online: 2016-06-01
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Vitamin D deficiency in pregnancy may affect fetal thymus development

Esra Bahar Gur, Mehmet Serkan Gur, Ozlem Ince, Esin Kasap, Mine Genc, Sumeyra Tatar, Sultan Bugday, Guluzar Arzu Turan, Serkan Guclu
DOI: 10.5603/GP.2016.0008
·
Pubmed: 27304655
·
Ginekol Pol 2016;87(5):378-383.

open access

Vol 87, No 5 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-06-01

Abstract

Objectives: The aim of our study was to evaluate the association of vitamin D deficiency (VDD) during pregnancy with thymus size in full-term fetuses.

Material and methods: In this prospective study, we evaluated mid-pregnancy serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations. The fetal thymus size was measured by ultrasound in the third trimester. Neonatal 25(OH)D3 levels were evaluated by umbilical cord blood sampling. Correlation of maternal and neonatal vitamin D levels and association between thymus size and both, maternal and neonatal vitamin D concentrations were investigated.

Results: Serum 25(OH) D3 concentrations were within the normal range in 48 (29.8%) mothers and 10 (13.1%) new­borns. A strong correlation between mid-pregnancy maternal and neonatal 25(OH)D3 concentration (r = 0.8, p < 0.001) was found. A significant linear correlation was observed between both, maternal and neonatal 25(OH)D3 concentrations and thymus perimeter length (r = 0.45, p = 0.04 and r = 0.43, p < 0.01, respectively). Both, maternal and fetal VDDs were associated with decreased thymus perimeter (p = 0.04, p = 0.03).

Conclusions: Vitamin D deficiency during pregnancy may be associated with smaller fetal thymus. Our data suggest that VDD in pregnancy may lead to systemic inflammatory response in the fetus.

Abstract

Objectives: The aim of our study was to evaluate the association of vitamin D deficiency (VDD) during pregnancy with thymus size in full-term fetuses.

Material and methods: In this prospective study, we evaluated mid-pregnancy serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations. The fetal thymus size was measured by ultrasound in the third trimester. Neonatal 25(OH)D3 levels were evaluated by umbilical cord blood sampling. Correlation of maternal and neonatal vitamin D levels and association between thymus size and both, maternal and neonatal vitamin D concentrations were investigated.

Results: Serum 25(OH) D3 concentrations were within the normal range in 48 (29.8%) mothers and 10 (13.1%) new­borns. A strong correlation between mid-pregnancy maternal and neonatal 25(OH)D3 concentration (r = 0.8, p < 0.001) was found. A significant linear correlation was observed between both, maternal and neonatal 25(OH)D3 concentrations and thymus perimeter length (r = 0.45, p = 0.04 and r = 0.43, p < 0.01, respectively). Both, maternal and fetal VDDs were associated with decreased thymus perimeter (p = 0.04, p = 0.03).

Conclusions: Vitamin D deficiency during pregnancy may be associated with smaller fetal thymus. Our data suggest that VDD in pregnancy may lead to systemic inflammatory response in the fetus.

Get Citation

Keywords

pregnancy, vitamin D deficiency, fetal thymus size

About this article
Title

Vitamin D deficiency in pregnancy may affect fetal thymus development

Journal

Ginekologia Polska

Issue

Vol 87, No 5 (2016)

Article type

Research paper

Pages

378-383

Published online

2016-06-01

DOI

10.5603/GP.2016.0008

Pubmed

27304655

Bibliographic record

Ginekol Pol 2016;87(5):378-383.

Keywords

pregnancy
vitamin D deficiency
fetal thymus size

Authors

Esra Bahar Gur
Mehmet Serkan Gur
Ozlem Ince
Esin Kasap
Mine Genc
Sumeyra Tatar
Sultan Bugday
Guluzar Arzu Turan
Serkan Guclu

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