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Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors
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Abstract
Objectives: Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors.
Material and methods: This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms. One hundred and seven patients recently diagnosed as having cervical intraepithelial neoplasm or invasive squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma based on pathology databases.
Results: Decreased or negative Human Epididymal Secretory Protein 4 expressions were determined in both normal cervical epithelia and in intraepithelial carcinomas, while increased HE4 expression was observed in invasive tumors.
Conclusions: This study demonstrated that altered expression of Human Epididymal Secretory Protein 4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between Human Epididymal Secretory Protein 4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas.
Abstract
Objectives: Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors.
Material and methods: This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms. One hundred and seven patients recently diagnosed as having cervical intraepithelial neoplasm or invasive squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma based on pathology databases.
Results: Decreased or negative Human Epididymal Secretory Protein 4 expressions were determined in both normal cervical epithelia and in intraepithelial carcinomas, while increased HE4 expression was observed in invasive tumors.
Conclusions: This study demonstrated that altered expression of Human Epididymal Secretory Protein 4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between Human Epididymal Secretory Protein 4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas.
Keywords
Uterine cervix, Human Epididymal Secretory Protein 4, HE4, squamous cell carcinoma, adenosquamous carcinoma, adenocarcinoma
About this articleTitle
Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors
Journal
Issue
Article type
Research paper
Pages
51-55
Published online
2017-02-28
Page views
1351
Article views/downloads
1390
DOI
10.5603/GP.a2017.0011
Pubmed
Bibliographic record
Ginekol Pol 2017;88(2):51-55.
Keywords
Uterine cervix
Human Epididymal Secretory Protein 4
HE4
squamous cell carcinoma
adenosquamous carcinoma
adenocarcinoma
Authors
Gulden Diniz
Tugba Karadeniz
Sevil Sayhan
Talya Akata
Fatma Aydiner
Duygu Ayaz
Dudu Solakoglu Kahraman
Tulay Akman
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