open access

Vol 87, No 11 (2016)
Research paper
Published online: 2016-11-30
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Association between rs7901695 and rs7903146 polymorphisms of the TCF7L2 gene and gestational diabetes in the population of Southern Poland

Malgorzata Michalak-Wojnowska, Daria Gorczyca-Siudak, Tomasz Gorczyca, Barbara Mosiewicz, Anna Kwaśniewska, Agata Filip, Jerzy Mosiewicz
DOI: 10.5603/GP.2016.0081
·
Pubmed: 27958632
·
Ginekol Pol 2016;87(11):745-750.

open access

Vol 87, No 11 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-11-30

Abstract

Objectives: The etiology of gestational diabetes mellitus (GDM) remains to be fully elucidated. Elevated risk for type 2 diabetes in patients with history of GDM and for GDM in women with familial history of diabetes may suggest that GDM and type 2 diabetes share a common genetic and environmental background. The TCF7L2 (Transcription Factor 7 Like 2) gene is one of the most important genetic factors of the established correlation with type 2 diabetes, and it may also play a role in the pathophysiology of GDM.
The aim of the study was to assess the influence of two polymorphisms of the TCF7L2 gene (rs7901695 and rs7903146), which are associated with the development of type 2 diabetes, in women with GDM.
Material and methods: The study included 50 women with glucose tolerance disorders diagnosed for the first time during the current pregnancy. Single nucleotide polymorphisms (SNPs) were genotyped using allelic discrimination. The results were confirmed using the sequencing method. Selected clinical parameters were also analyzed.
Results: No correlation between the studied polymorphisms of the TCF7L2 gene and GDM was observed. Glycemic control with diet or diet and insulin was associated with better control of the weight gain during pregnancy.
Conclusions: No correlation between rs7903146 and rs7901695 polymorphisms of the TCF7L2 gene and GDM was found. Glycemic control with diet or diet and insulin is associated with better control of the weight gain during pregnancy.

Abstract

Objectives: The etiology of gestational diabetes mellitus (GDM) remains to be fully elucidated. Elevated risk for type 2 diabetes in patients with history of GDM and for GDM in women with familial history of diabetes may suggest that GDM and type 2 diabetes share a common genetic and environmental background. The TCF7L2 (Transcription Factor 7 Like 2) gene is one of the most important genetic factors of the established correlation with type 2 diabetes, and it may also play a role in the pathophysiology of GDM.
The aim of the study was to assess the influence of two polymorphisms of the TCF7L2 gene (rs7901695 and rs7903146), which are associated with the development of type 2 diabetes, in women with GDM.
Material and methods: The study included 50 women with glucose tolerance disorders diagnosed for the first time during the current pregnancy. Single nucleotide polymorphisms (SNPs) were genotyped using allelic discrimination. The results were confirmed using the sequencing method. Selected clinical parameters were also analyzed.
Results: No correlation between the studied polymorphisms of the TCF7L2 gene and GDM was observed. Glycemic control with diet or diet and insulin was associated with better control of the weight gain during pregnancy.
Conclusions: No correlation between rs7903146 and rs7901695 polymorphisms of the TCF7L2 gene and GDM was found. Glycemic control with diet or diet and insulin is associated with better control of the weight gain during pregnancy.

Get Citation

Keywords

genetic polymorphism; gestational diabetes mellitus; TCF7L2 gene

About this article
Title

Association between rs7901695 and rs7903146 polymorphisms of the TCF7L2 gene and gestational diabetes in the population of Southern Poland

Journal

Ginekologia Polska

Issue

Vol 87, No 11 (2016)

Article type

Research paper

Pages

745-750

Published online

2016-11-30

DOI

10.5603/GP.2016.0081

Pubmed

27958632

Bibliographic record

Ginekol Pol 2016;87(11):745-750.

Keywords

genetic polymorphism
gestational diabetes mellitus
TCF7L2 gene

Authors

Malgorzata Michalak-Wojnowska
Daria Gorczyca-Siudak
Tomasz Gorczyca
Barbara Mosiewicz
Anna Kwaśniewska
Agata Filip
Jerzy Mosiewicz

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