open access

Vol 84, No 4 (2013)
ARTICLES
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Three pregnancies in a Marfan syndrome patient after a mitral and tricuspid valve surgery

Jacek Zamłyński, Anita Olejek, Alicja Gajewska-Kucharek, Ewa Horzelska, Michael P. Carson, Monika Rykaczewska-Czerwińska, Jerzy Chudek, Piotr Bodzek
DOI: 10.17772/gp/1583
·
Ginekol Pol 2013;84(4).

open access

Vol 84, No 4 (2013)
ARTICLES

Abstract

Marfan syndrome is an autosomal dominant disorder of connective tissue with up to 25% of cases related to a spontaneous mutation. It has been associated with perinatal loss, preterm labor, and, potentially, a rupture of the maternal aortic arch. We present a case of a woman diagnosed with Marfan syndrome after a miscarriage of her first pregnancy. At the time of diagnosis she had mild aortic bulb dilation and insufficiency of the mitral and tricuspid valves. She underwent cardiosurgical correction, after which she had two uneventful pregnancies. This case suggests that preconceptional correction of valve defects in women with Marfan syndrome may decrease the risk of cardiac decompensation during future pregnancies. Additionally, close clinical follow up and the appropriate use of beta-adrenergic blockade may decrease the risk of aortic rupture, a significant risk factor for mortality in pregnant women.

Abstract

Marfan syndrome is an autosomal dominant disorder of connective tissue with up to 25% of cases related to a spontaneous mutation. It has been associated with perinatal loss, preterm labor, and, potentially, a rupture of the maternal aortic arch. We present a case of a woman diagnosed with Marfan syndrome after a miscarriage of her first pregnancy. At the time of diagnosis she had mild aortic bulb dilation and insufficiency of the mitral and tricuspid valves. She underwent cardiosurgical correction, after which she had two uneventful pregnancies. This case suggests that preconceptional correction of valve defects in women with Marfan syndrome may decrease the risk of cardiac decompensation during future pregnancies. Additionally, close clinical follow up and the appropriate use of beta-adrenergic blockade may decrease the risk of aortic rupture, a significant risk factor for mortality in pregnant women.
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Keywords

Marfan syndrome, Perinatal loss, preterm labor

About this article
Title

Three pregnancies in a Marfan syndrome patient after a mitral and tricuspid valve surgery

Journal

Ginekologia Polska

Issue

Vol 84, No 4 (2013)

DOI

10.17772/gp/1583

Bibliographic record

Ginekol Pol 2013;84(4).

Keywords

Marfan syndrome
Perinatal loss
preterm labor

Authors

Jacek Zamłyński
Anita Olejek
Alicja Gajewska-Kucharek
Ewa Horzelska
Michael P. Carson
Monika Rykaczewska-Czerwińska
Jerzy Chudek
Piotr Bodzek

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