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Mechanizm, działanie i skuteczność glikokortykosteroidów w polimialgii reumatycznej i olbrzymiokomórkowym zapaleniu tętnic –– czy te leki są zawsze skuteczne?
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- Katedra i Klinika Reumatologii, Rehabilitacji i Chorób Wewnętrznych, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Fredry 10, 61-701 Poznań
- Rheumatology Research Group, Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im W. Degi, ul. 28 Czerwca 1956 r. 135/147, 61-545 Poznań, Poland
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Abstract
W terapii polimialgii reumatycznej (PMR, polymialgia rheumatica) i olbrzymiokomórkowego zapalenia tętnic (GCA, giant cells arthritis) lekami pierwszego wyboru są glikokortykosteroidy (GKS). Powyższe choroby wymagają często wieloletniego leczenia, dlatego należy zwrócić szczególną uwagę na szerokie spektrum działań niepożądanych tych leków. Problemem, z którym można spotkać się w praktyce klinicznej, jest steroidooporność. W niniejszej publikacji zebrano najnowsze doniesienia naukowe dotyczących skuteczności terapii GKS w PMR współistniejącej (lub nie) z GCA.
Abstract
W terapii polimialgii reumatycznej (PMR, polymialgia rheumatica) i olbrzymiokomórkowego zapalenia tętnic (GCA, giant cells arthritis) lekami pierwszego wyboru są glikokortykosteroidy (GKS). Powyższe choroby wymagają często wieloletniego leczenia, dlatego należy zwrócić szczególną uwagę na szerokie spektrum działań niepożądanych tych leków. Problemem, z którym można spotkać się w praktyce klinicznej, jest steroidooporność. W niniejszej publikacji zebrano najnowsze doniesienia naukowe dotyczących skuteczności terapii GKS w PMR współistniejącej (lub nie) z GCA.
Keywords
polimialgia reumatyczna; olbrzymiokomórkowe zapalenie tętnic; steroidoterapia
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Title
Mechanizm, działanie i skuteczność glikokortykosteroidów w polimialgii reumatycznej i olbrzymiokomórkowym zapaleniu tętnic –– czy te leki są zawsze skuteczne?
Journal
Issue
Article type
Review paper
Pages
27-34
Published online
2021-05-20
Page views
2719
Article views/downloads
515
DOI
Bibliographic record
Forum Reumatol 2021;7(1):27-34.
Keywords
polimialgia reumatyczna
olbrzymiokomórkowe zapalenie tętnic
steroidoterapia
Authors
Bogna Grygiel-Górniak
Agnieszka Szczepańska
Marta Lubarska
Włodzimierz Samborski
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