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Primary Sjögren syndrome complicated by vasculitis and non-Hodgkin lymphoma
Affiliations- KCM, Kopernika 32, 31-501 Krakow, Poland
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Abstract
Sjögren syndrome (SS) is a chronic inflammatory disease of autoimmune origin. During its course, lymphocytic infiltrates within the exocrine glands (primarily lacrimal and salivary glands) cause damage to these glands and impairment of their functions, leading to, among others, symptoms of dryness typical for SS. In approx. 70–80% of patients, glandular lesions
may be accompanied by involvement of, and subsequent damage to, other organs and systems. Some of the most serious, life-threatening organ complications include vasculitis, nervous system involvement and development of non-Hodgkin lymphomas ( NHLs). This article describes a case of a 64-year-old patient with primary Sjögren syndrome, in whom the course of the disease led to deterioration of health with symptoms of vasculitis and peripheral nervous system involvement, eventually ending in diagnosis of a non-Hodgkin lymphoma (NHL). The authors point out the significant heterogeneity of symptoms in the course of SS and emphasize the need to identify and closely monitor patients who are at high risk of developing a lymphoproliferative process.
Forum Reumatol. 2019, tom 5, nr 4: 197–199
Abstract
Sjögren syndrome (SS) is a chronic inflammatory disease of autoimmune origin. During its course, lymphocytic infiltrates within the exocrine glands (primarily lacrimal and salivary glands) cause damage to these glands and impairment of their functions, leading to, among others, symptoms of dryness typical for SS. In approx. 70–80% of patients, glandular lesions
may be accompanied by involvement of, and subsequent damage to, other organs and systems. Some of the most serious, life-threatening organ complications include vasculitis, nervous system involvement and development of non-Hodgkin lymphomas ( NHLs). This article describes a case of a 64-year-old patient with primary Sjögren syndrome, in whom the course of the disease led to deterioration of health with symptoms of vasculitis and peripheral nervous system involvement, eventually ending in diagnosis of a non-Hodgkin lymphoma (NHL). The authors point out the significant heterogeneity of symptoms in the course of SS and emphasize the need to identify and closely monitor patients who are at high risk of developing a lymphoproliferative process.
Forum Reumatol. 2019, tom 5, nr 4: 197–199
Keywords
Sjögren syndrome; lymphoma; cryoglobulins; vasculitis
About this articleTitle
Primary Sjögren syndrome complicated by vasculitis and non-Hodgkin lymphoma
Journal
Issue
Article type
Case report
Pages
197-199
Published online
2020-02-05
Page views
482
Article views/downloads
716
DOI
10.5603/R.2019.0021
Bibliographic record
Forum Reumatol 2019;5(4):197-199.
Keywords
Sjögren syndrome
lymphoma
cryoglobulins
vasculitis
Authors
Mateusz Moskal
Jolanta Osieleniec
Piotr Krawiec
Małgorzata Pukal
Bogdan Batko
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