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Vol 5, No 1 (2019)
Review paper
Published online: 2019-04-04
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Budowa i funkcja ludzkich antygenów zgodności tkankowej. Część 3. Rola antygenów MHC w chorobach reumatycznych

Krzysztof Wiktorowicz1, Krzysztof Kaszkowiak1, Włodzimierz Samborski2
DOI: 10.5603/FR.2019.0005
·
Forum Reumatol 2019;5(1):33-42.
Affiliations
  1. 1. Katedra Biologii i Ochrony Środowiska, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
  2. Katedra i Klinika Reumatologii i Rehabilitacji, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

open access

Vol 5, No 1 (2019)
Review
Published online: 2019-04-04

Abstract

Ekspresja określonych alleli zgodności tkankowej stanowi czynnik ryzyka chorób reumatycznych. W reumatoidalnym zapaleniu stawów jest to obecność antygenów HLA-DRB1, z charakterystyczną sekwencją pięciu aminokwasów (glutamina, lizyna, arginina, alanina) w pozycjach od 70 do 74 łańcucha, nazywanych najczęściej wspólnym epitopem. Charakterystyczna dla zesztywniającego zapalenie stawów kręgosłupa jest ekspresja antygenu zgodności tkankowej HLA-B27, który może prezentować nieprawidłowo przetworzone peptydy antygenowe. Wydaje się, że cząsteczki HLA-B27 mogą z większą wydajnością prezentować autoreaktywnym limfocytom T patogenne peptydy bakteryjne albo endogenne peptydy artrytogenne. W biologii chorób reumatycznych ważną rolę mogą odgrywać także polimorfizmy pojedynczego nukleotydu (SNP, single nucleotide polymorphism) czy mechanizmy epigenetyczne, wpływające na ekspresję genów.

Forum Reumatol. 2019, tom 5, nr 1: 33–42

Abstract

Ekspresja określonych alleli zgodności tkankowej stanowi czynnik ryzyka chorób reumatycznych. W reumatoidalnym zapaleniu stawów jest to obecność antygenów HLA-DRB1, z charakterystyczną sekwencją pięciu aminokwasów (glutamina, lizyna, arginina, alanina) w pozycjach od 70 do 74 łańcucha, nazywanych najczęściej wspólnym epitopem. Charakterystyczna dla zesztywniającego zapalenie stawów kręgosłupa jest ekspresja antygenu zgodności tkankowej HLA-B27, który może prezentować nieprawidłowo przetworzone peptydy antygenowe. Wydaje się, że cząsteczki HLA-B27 mogą z większą wydajnością prezentować autoreaktywnym limfocytom T patogenne peptydy bakteryjne albo endogenne peptydy artrytogenne. W biologii chorób reumatycznych ważną rolę mogą odgrywać także polimorfizmy pojedynczego nukleotydu (SNP, single nucleotide polymorphism) czy mechanizmy epigenetyczne, wpływające na ekspresję genów.

Forum Reumatol. 2019, tom 5, nr 1: 33–42

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Keywords

HLA-DRB1; wspólny epitop; HLA-B27; prezentacja antygenu

About this article
Title

Budowa i funkcja ludzkich antygenów zgodności tkankowej. Część 3. Rola antygenów MHC w chorobach reumatycznych

Journal

Rheumatology Forum

Issue

Vol 5, No 1 (2019)

Article type

Review paper

Pages

33-42

Published online

2019-04-04

Page views

877

Article views/downloads

2955

DOI

10.5603/FR.2019.0005

Bibliographic record

Forum Reumatol 2019;5(1):33-42.

Keywords

HLA-DRB1
wspólny epitop
HLA-B27
prezentacja antygenu

Authors

Krzysztof Wiktorowicz
Krzysztof Kaszkowiak
Włodzimierz Samborski

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