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Calciphylaxis — pathogenesis and clinical picture
Affiliations- Śląski Uniwersytet Medyczny w Katowicach Katedra i Klinika Chorób Wewnętrznych i reumatologii
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Abstract
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare vascular disease caused by deposition of calcium salts in vessel walls, accompanied by coagulation disorders, which leads to extensive skin ulceration and soft tissue necrosis. Typical cases of calciphylaxis are usually described in patients with renal failure, though it is currently known that approx. 1/10th of all cases stem from other causes, including systemic inflammation, metabolic disorders and endocrine disorders. This article shows an overview of the most important pathophysiological phenomena which accompany calciphylaxis, characterizes the clinical picture of the disease and presents available approaches to therapeutic management. Forum Reumatol. 2019, tom 5, nr 1: 14–20
Abstract
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare vascular disease caused by deposition of calcium salts in vessel walls, accompanied by coagulation disorders, which leads to extensive skin ulceration and soft tissue necrosis. Typical cases of calciphylaxis are usually described in patients with renal failure, though it is currently known that approx. 1/10th of all cases stem from other causes, including systemic inflammation, metabolic disorders and endocrine disorders. This article shows an overview of the most important pathophysiological phenomena which accompany calciphylaxis, characterizes the clinical picture of the disease and presents available approaches to therapeutic management. Forum Reumatol. 2019, tom 5, nr 1: 14–20
Keywords
calciphylaxis; vasculitis; end-stage renal disease
About this articleTitle
Calciphylaxis — pathogenesis and clinical picture
Journal
Issue
Article type
Review paper
Pages
14-20
Published online
2019-04-04
Page views
673
Article views/downloads
941
DOI
Bibliographic record
Forum Reumatol 2019;5(1):14-20.
Keywords
calciphylaxis
vasculitis
end-stage renal disease
Authors
Beata Dubiel-Braszczok
Magdalena Włoch-Targońska
Przemysław Jacek Kotyla
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