Vol 6, No 3 (2020)
Review paper
Published online: 2020-09-09
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Sekukinumab w leczeniu spondyloartropatii zapalnych

Dorota Sikorska, Włodzimierz Samborski
DOI: 10.5603/FR.2020.0014
·
Forum Reumatologiczne 2020;6(3):125-130.

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Vol 6, No 3 (2020)
Prace poglądowe
Published online: 2020-09-09

Abstract

W początkowym okresie badań nad patogenezą spondyloartropatii seronegatywnych (SpA) kluczową rolę przypisywano limfocytom Th1 oraz czynnikowi martwicy nowotworów-alfa (TNF-α, tumor necrosis factor alpha). Kolejne lata przyniosły jednak dowody na istotne znaczenie odmiennych czynników zapalnych między innymi interleukiny-17 (IL-17). Sekukinumab, który jest w pełni ludzkim przeciwciałem monoklonalnym neutralizującym prozapalną interleukinę-17A, jest pierwszym i obecnie jedynym zarejestrowanym lekiem biologiczny o innym niż  inhibicja TNF-α mechanizmie działania, którego skuteczność w leczeniu SpA została potwierdzona w badaniach klinicznych. W niniejszej publikacji przedstawimy informacje na temat zastosowania sekukinumabu w leczeniu SpA, wraz z własnymi doświadczeniami klinicznymi.

Abstract

W początkowym okresie badań nad patogenezą spondyloartropatii seronegatywnych (SpA) kluczową rolę przypisywano limfocytom Th1 oraz czynnikowi martwicy nowotworów-alfa (TNF-α, tumor necrosis factor alpha). Kolejne lata przyniosły jednak dowody na istotne znaczenie odmiennych czynników zapalnych między innymi interleukiny-17 (IL-17). Sekukinumab, który jest w pełni ludzkim przeciwciałem monoklonalnym neutralizującym prozapalną interleukinę-17A, jest pierwszym i obecnie jedynym zarejestrowanym lekiem biologiczny o innym niż  inhibicja TNF-α mechanizmie działania, którego skuteczność w leczeniu SpA została potwierdzona w badaniach klinicznych. W niniejszej publikacji przedstawimy informacje na temat zastosowania sekukinumabu w leczeniu SpA, wraz z własnymi doświadczeniami klinicznymi.

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Keywords

sekukinumab; spondyloartropatie zapalne; interleukina 17

About this article
Title

Sekukinumab w leczeniu spondyloartropatii zapalnych

Journal

Forum Reumatologiczne

Issue

Vol 6, No 3 (2020)

Article type

Review paper

Pages

125-130

Published online

2020-09-09

DOI

10.5603/FR.2020.0014

Bibliographic record

Forum Reumatologiczne 2020;6(3):125-130.

Keywords

sekukinumab
spondyloartropatie zapalne
interleukina 17

Authors

Dorota Sikorska
Włodzimierz Samborski

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