open access

Vol 3, No 1 (2017)
Review paper
Published online: 2017-04-19
Get Citation

Zastosowanie aceklofenaku w leczeniu chorób reumatycznych

Dorota Sikorska, Włodzimierz Samborski
Forum Reumatol 2017;3(1):29-34.

open access

Vol 3, No 1 (2017)
Review
Published online: 2017-04-19

Abstract

Niesteroidowe leki przeciwzapalne nadal są szeroko stosowane i zajmują ważne miejsce w reumatologii. Niestety, wszystkie niesteroidowe leki przeciwzapal­ne mogą wywołać charakterystyczne działania nie­pożądane, dlatego poszukuje się leków o większym profilu bezpieczeństwa. Wiele badań klinicznych potwierdza dobrą skuteczność i bezpieczeństwo aceklofenaku w leczeniu chorób reumatycznych, co skłania do jego stosowania w codziennej praktyce klinicznej. W artykule przedstawiono krótką charakte­rystykę i zastosowanie aceklofenaku w reumatologii.

Abstract

Niesteroidowe leki przeciwzapalne nadal są szeroko stosowane i zajmują ważne miejsce w reumatologii. Niestety, wszystkie niesteroidowe leki przeciwzapal­ne mogą wywołać charakterystyczne działania nie­pożądane, dlatego poszukuje się leków o większym profilu bezpieczeństwa. Wiele badań klinicznych potwierdza dobrą skuteczność i bezpieczeństwo aceklofenaku w leczeniu chorób reumatycznych, co skłania do jego stosowania w codziennej praktyce klinicznej. W artykule przedstawiono krótką charakte­rystykę i zastosowanie aceklofenaku w reumatologii.

Get Citation

Keywords

niesteroidowe leki przeciwzapalne, aceklofenak, choroby reumatyczne

About this article
Title

Zastosowanie aceklofenaku w leczeniu chorób reumatycznych

Journal

Rheumatology Forum

Issue

Vol 3, No 1 (2017)

Article type

Review paper

Pages

29-34

Published online

2017-04-19

Page views

1209

Article views/downloads

3010

Bibliographic record

Forum Reumatol 2017;3(1):29-34.

Keywords

niesteroidowe leki przeciwzapalne
aceklofenak
choroby reumatyczne

Authors

Dorota Sikorska
Włodzimierz Samborski

References (30)
  1. Kostowski W., Herman Z.: Farmakologia. Podstawy farmakoterapii. Wydawnictwo Lekarskie PZWL, Warszawa 2006
  2. Samborski W., Brzosko M.: Reumatologia praktyczna. Wydawnictwo Wolters Kluwert Polska SP. z o.o., Warszawa 2011
  3. Dooley M, Spencer CM, Dunn CJ. Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease. Drugs. 2001; 61(9): 1351–1378.
  4. Schattenkirchner M, Milachowski KA. A double-blind, multicentre, randomised clinical trial comparing the efficacy and tolerability of aceclofenac with diclofenac resinate in patients with acute low back pain. Clin Rheumatol. 2003; 22(2): 127–135.
  5. Batlle-Gualda E, Román Ivorra J, Martín-Mola E, et al. Aceclofenac vs paracetamol in the management of symptomatic osteoarthritis of the knee: a double-blind 6-week randomized controlled trial. Osteoarthritis Cartilage. 2007; 15(8): 900–908.
  6. Kornasoff D, Frerick H, Bowdler J, et al. Aceclofenac is a well-tolerated alternative to naproxen in the treatment of osteoarthritis. Clin Rheumatol. 1997; 16(1): 32–38.
  7. Martín-Mola E, Gijón-Baños J, Ansoleaga JJ. Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. Rheumatol Int. 1995; 15(3): 111–116.
  8. Pasero G, Marcolongo R, Serni U, et al. A multi-centre, double-blind comparative study of the efficacy and safety of aceclofenac and diclofenac in the treatment of rheumatoid arthritis. Curr Med Res Opin. 1995; 13(6): 305–315.
  9. Batlle-Gualda E, Figueroa M, Ivorra J, et al. The efficacy and tolerability of aceclofenac in the treatment of patients with ankylosing spondylitis: a multicenter controlled clinical trial. Aceclofenac Indomethacin Study Group. J Rheumatol. 1996; 23(7): 1200–1206.
  10. Frölich JC. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol Sci. 1997; 18(1): 30–34.
  11. Patrignani P, Panara MR, Sciulli MG, et al. Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs. J Physiol Pharmacol. 1997; 48(4): 623–631.
  12. Bort R, Ponsoda X, Carrasco E, et al. Metabolism of aceclofenac in humans. Drug Metab Dispos. 1996; 24(8): 834–841.
  13. Henrotin Y, de Leval X, Mathy-Hartet M, et al. In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators. Inflamm Res. 2001; 50(8): 391–399.
  14. Maneiro E, López-Armada MJ, Fernández-Sueiro JL, et al. Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes. J Rheumatol. 2001; 28(12): 2692–2699.
  15. Yamazaki R, Kawai S, Mizushima Y, et al. A major metabolite of aceclofenac, 4'-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells. Inflamm Res. 2000; 49(3): 133–138.
  16. Akimoto H, Yamazaki R, Hashimoto S, et al. 4'-Hydroxy aceclofenac suppresses the interleukin-1-induced production of promatrix metalloproteinases and release of sulfated-glycosaminoglycans from rabbit articular chondrocytes. Eur J Pharmacol. 2000; 401(3): 429–436.
  17. Blot L, Marcelis A, Devogelaer JP, et al. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage. Br J Pharmacol. 2000; 131(7): 1413–1421.
  18. MacDonald TM. Epidemiology and pharmacoeconomic implications of non-steroidal anti-inflammatory drug-associated gastrointestinal toxicity. Rheumatology. 2000; 39(suppl 2): 13–20.
  19. Nagai J, Uesawa Y, Shimamura R, et al. Characterization of the Adverse Effects Induced by Acetaminophen and Non-steroidal Anti-Inflammatory Drugs based on the Analysis of the Japanese Adverse Drug Event Report Database. Clin J Pain. 2016 [Epub ahead of print].
  20. Bjorkman DJ. One hundred years of NSAID gastropathy: are coxibs the answer? Rev Gastroenterol Disord. 2001; 1(3): 121–127.
  21. Arfè A, Scotti L, Varas-Lorenzo C, et al. Safety of Non-steroidal Anti-inflammatory Drugs (SOS) Project Consortium. Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study. BMJ. 2016; 354: i4857.
  22. Międzyborski R. Kierunki poszukiwań i zastosowanie niesteroidowych leków przeciwzapalnych. Postepy Hig Med Dosw. 2004; 58: 438–448.
  23. Pareek A, Chandanwale AS, Oak J, et al. Efficacy and safety of aceclofenac in the treatment of osteoarthritis: a randomized double-blind comparative clinical trial versus diclofenac - an Indian experience. Curr Med Res Opin. 2006; 22(5): 977–988.
  24. Lapeyre-Mestre M, Grolleau S, Montastruc JL, et al. Association Française des Centres Régionaux de Pharmacovigilance (CRPV). Adverse drug reactions associated with the use of NSAIDs: a case/noncase analysis of spontaneous reports from the French pharmacovigilance database 2002-2006. Fundam Clin Pharmacol. 2013; 27(2): 223–230.
  25. Laporte JR, Ibáñez L, Vidal X, et al. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Saf. 2004; 27(6): 411–420.
  26. Castellsague J, Riera-Guardia N, Calingaert B, et al. Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012; 35(12): 1127–1146.
  27. Legrand E. Aceclofenac in the management of inflammatory pain. Expert Opin Pharmacother. 2004; 5(6): 1347–1357.
  28. Hawkey CJ, Ell C, Simon B, et al. Less small-bowel injury with lumiracoxib compared with naproxen plus omeprazole. Clin Gastroenterol Hepatol. 2008; 6(5): 536–544.
  29. Maiden L, Thjodleifsson B, Theodors A, et al. A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology. 2005; 128(5): 1172–1178.
  30. Goldstein JL, Eisen GM, Lewis B, et al. Investigators. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol. 2005; 3(2): 133–141.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl