Vol 12, No 2 (2019)
Przypadki kliniczne
Published online: 2019-07-11

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Unilateral optic neuropathy in a patient on tacrolimus therapy after kidney transplantation

Agnieszka Tarasewicz1, Anna Gębka2, Ewa Serkies-Minuth2, Dorota Raczyńska2, Mateusz Ślizień2, Alicja Dębska-Ślizień1, Leopold Glasner2
Forum Nefrologiczne 2019;12(2):101-105.

Abstract

Tacrolimus, is a calcineurin inhibitor used in immu­nosuppressive treatment after kidney transplanta­tion with known potential neurotoxic effects. A rare complication that may occur even several years of tacrolimus therapy and manifest by serious vi­sual loss is optic neuropathy. Discontinuation of tacrolimus therapy rarely leads to improvement, but carries the risk of transplanted organ dysfunc­tion. We present a case report of a patient after kidney transplantation with unilateral optic neuro­pathy, which occurred after 3 years of tacrolimus use with maintenance of recommended therapeutic levels. In the presented case, local and systemic treatment with steroids, as well as continuation of tacrolimus at a reduced daily dose allowed for ma­intenance of transplanted kidney function without progressive atrophy of optic nerve.

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Renal Disease and Transplantation Forum