Pharmacotherapy of diabetes in patients with chronic kidney disease

Abstract

Treating diabetes means keeping a normal and stable blood glucose levels and preventing hypoglycemia. Doing so is especially difficult in patients with dia­betes mellitus and chronic kidney disease because the antidiabetic drugs metabolism may be disturbed by impaired glomerular filtration rate. As a result, the drug action might be diminished and the risk of side effects is increased. Recent years saw a sig­nificant progress in pharmacotherapy of diabetes. In this paper we systematize the current knowledge on various treatments with antidiabetic drugs in patients with chronic kidney disease, including those on re­nal replacement therapy.