Vol 5, No 4 (2012)
Prace poglądowe
Published online: 2012-12-28

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The hemolytic-uremic syndrome in children

Aleksandra Żurowska
Forum Nefrologiczne 2012;5(4):283-288.

Abstract

Major advances have been made in the recognition
of the causes leading to both hemolytic-uremic
syndrome (HUS) and thrombotic thrombocytopenic
purpura in children. Early recognition of
the different etiologies of these syndromes is essential
for prompt institution of different treatment
options which remain symptomatic in HUS associated
with EHEC and Streptococcus pneumonia
infection and involve plasma infusions or plasmapheresis
in atypical HUS. Further laboratory and
genetic diagnosis of atypical HUS is available in
a few specialized centres. The precise recognition
of the genetic defect or acquired cause of atypical
HUS is necessary for planning further prophylactic
therapy and that of recurrences in both the
native and transplanted kidney. The existing therapeutic
options increase the chances of longterm
survival of children suffering from this devastating
disease.

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