open access

Vol 3, No 2 (2017)
Review paper
Published online: 2017-08-21
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New therapies of treatment for patients with advanced melanoma

Magdalena Ciążyńska1, Marta Pabianek1, Joanna Narbutt2, Aleksandra Lesiak2
Forum Dermatologicum 2017;3(2):53-57.
Affiliations
  1. Oddział Chorób Rozrostowych, Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi, ul. Pabianicka 62, 93-513 Łódź
  2. Klinika Dermatologii, Dermatologii Dziecięcej i Onkologicznej Uniwersytetu Medycznego w Łodzi

open access

Vol 3, No 2 (2017)
REVIEW ARTICLES
Published online: 2017-08-21

Abstract

Cutaneous melanomas are malignant tumors deriving from melanocytes. Despite the fact that this type of tumor represents less than 2% of all tumors, it causes the highest mortality. Due to the fact that classical type of treatment with application of cytostatic drugs is not effective, the analysis of treatment in patients with advanced melanoma during last 6 years is mostly focused on two particular kind of therapies. The first one is immunotherapy based on application of antibodies against anti-programmed death receptor-1 (anti-PD-1) — pembrolizumab, nivolumab, used in monotherapy or therapy combined with antibodies against cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) — ipilimumab. The second one is molecular targeted therapy that is applied to patients with advanced melanoma with mutation in gene BRAF including combination of inhibitors BRAF and MEK (dabrafenib with trametinib or vemurafenib with cobimetinib), that is more effective than monotherapy of these drugs separately. This paper includes information about related works describing the latest drugs and combination between them that provide the most effective activity in therapies for advanced melanoma.

Abstract

Cutaneous melanomas are malignant tumors deriving from melanocytes. Despite the fact that this type of tumor represents less than 2% of all tumors, it causes the highest mortality. Due to the fact that classical type of treatment with application of cytostatic drugs is not effective, the analysis of treatment in patients with advanced melanoma during last 6 years is mostly focused on two particular kind of therapies. The first one is immunotherapy based on application of antibodies against anti-programmed death receptor-1 (anti-PD-1) — pembrolizumab, nivolumab, used in monotherapy or therapy combined with antibodies against cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) — ipilimumab. The second one is molecular targeted therapy that is applied to patients with advanced melanoma with mutation in gene BRAF including combination of inhibitors BRAF and MEK (dabrafenib with trametinib or vemurafenib with cobimetinib), that is more effective than monotherapy of these drugs separately. This paper includes information about related works describing the latest drugs and combination between them that provide the most effective activity in therapies for advanced melanoma.

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Keywords

skin melanoma, immunotherapy, BRAF inhibitor, MEK inhibitor

About this article
Title

New therapies of treatment for patients with advanced melanoma

Journal

Forum Dermatologicum

Issue

Vol 3, No 2 (2017)

Article type

Review paper

Pages

53-57

Published online

2017-08-21

Page views

561

Article views/downloads

13591

Bibliographic record

Forum Dermatologicum 2017;3(2):53-57.

Keywords

skin melanoma
immunotherapy
BRAF inhibitor
MEK inhibitor

Authors

Magdalena Ciążyńska
Marta Pabianek
Joanna Narbutt
Aleksandra Lesiak

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