open access
The use of methotrexate in the treatment of selected autoimmune connective tissue diseases — our own experience and review of the literature data
open access
Abstract
Methotrexate (MTX) belongs to the most commonly used immunosuppressants in dermatology. Correct classification of the patient, taking into account possible contraindications may minimize the risk of adverse effects of MTX, while the emergence of new forms for applications of MTX — subcutaneous prefilled syringes — significantly improved bioavailability
compared to oral treatment and allowed to increase the efficacy and safety of the treatment. We present our experience with the use of subcutaneous MTX in the treatment of chronic cutaneous lupus erythematosus (Discoid Lupus Erythematosus, DLE) and in generalized as well as deep forms of morphea. In addition, we reviewed the literature and current guidelines regarding treatment of both diseases.
Abstract
Methotrexate (MTX) belongs to the most commonly used immunosuppressants in dermatology. Correct classification of the patient, taking into account possible contraindications may minimize the risk of adverse effects of MTX, while the emergence of new forms for applications of MTX — subcutaneous prefilled syringes — significantly improved bioavailability
compared to oral treatment and allowed to increase the efficacy and safety of the treatment. We present our experience with the use of subcutaneous MTX in the treatment of chronic cutaneous lupus erythematosus (Discoid Lupus Erythematosus, DLE) and in generalized as well as deep forms of morphea. In addition, we reviewed the literature and current guidelines regarding treatment of both diseases.
Keywords
methotrxate; autoimmune connective tissue diseases; morphea; dyscoid lupus erthematosus; DLE
Title
The use of methotrexate in the treatment of selected autoimmune connective tissue diseases — our own experience and review of the literature data
Journal
Issue
Article type
Case report
Pages
165-170
Published online
2017-02-14
Page views
380
Article views/downloads
2739
Bibliographic record
Forum Dermatologicum 2016;2(4):165-170.
Keywords
methotrxate
autoimmune connective tissue diseases
morphea
dyscoid lupus erthematosus
DLE
Authors
Adriana Polańska
Aleksandra Dańczak-Pazdrowska
Ryszard Żaba
Zygmunt Adamski