open access

Vol 2, No 3 (2016)
Review paper
Published online: 2016-11-23
Get Citation

Causes of the endothelial disfunction in systemic lupus erythematosus. Endothelial disfunction markers

Kamila Karolina Tokarska, Anna Woźniacka
Forum Dermatologicum 2016;2(3):102-104.

open access

Vol 2, No 3 (2016)
REVIEW ARTICLES
Published online: 2016-11-23

Abstract

Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disease with multiple organ involvement. This entity is associated with accelerated atherosclerosis and increased risk of cardiovascular diseases. Endothelial dysfunction represents a key step in the initiation and maintenance of atherosclerosis and may serve as a marker for future risk of cardiovascular events. Many factors, including circulating inflammatory cytokines, reactive oxygen species, low density lipoprotein, autoantibodies, vascular endothelial growth factor, circulating endothelial cells and von Willebrand factor may activate endothelial cells, leading to impaired vascular relaxation increased leukocyte adhesion, increased endothelial permeability and generation of a pro-thrombotic state. In this paper potential mechanism of endothelial dysfunction in SLE patients were discussed.

Abstract

Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disease with multiple organ involvement. This entity is associated with accelerated atherosclerosis and increased risk of cardiovascular diseases. Endothelial dysfunction represents a key step in the initiation and maintenance of atherosclerosis and may serve as a marker for future risk of cardiovascular events. Many factors, including circulating inflammatory cytokines, reactive oxygen species, low density lipoprotein, autoantibodies, vascular endothelial growth factor, circulating endothelial cells and von Willebrand factor may activate endothelial cells, leading to impaired vascular relaxation increased leukocyte adhesion, increased endothelial permeability and generation of a pro-thrombotic state. In this paper potential mechanism of endothelial dysfunction in SLE patients were discussed.

Get Citation

Keywords

lupus erythematosus; vascular endothelium; endothelial dysfunction

About this article
Title

Causes of the endothelial disfunction in systemic lupus erythematosus. Endothelial disfunction markers

Journal

Forum Dermatologicum

Issue

Vol 2, No 3 (2016)

Article type

Review paper

Pages

102-104

Published online

2016-11-23

Page views

583

Article views/downloads

5947

Bibliographic record

Forum Dermatologicum 2016;2(3):102-104.

Keywords

lupus erythematosus
vascular endothelium
endothelial dysfunction

Authors

Kamila Karolina Tokarska
Anna Woźniacka

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
phone: +48 58 320 94 94, fax: +48 58 320 94 60, e-mail: viamedica@viamedica.pl