open access
Causes of the endothelial disfunction in systemic lupus erythematosus. Endothelial disfunction markers
open access
Abstract
Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disease with multiple organ involvement. This entity is associated with accelerated atherosclerosis and increased risk of cardiovascular diseases. Endothelial dysfunction represents a key step in the initiation and maintenance of atherosclerosis and may serve as a marker for future risk of cardiovascular events. Many factors, including circulating inflammatory cytokines, reactive oxygen species, low density lipoprotein, autoantibodies, vascular endothelial growth factor, circulating endothelial cells and von Willebrand factor may activate endothelial cells, leading to impaired vascular relaxation increased leukocyte adhesion, increased endothelial permeability and generation of a pro-thrombotic state. In this paper potential mechanism of endothelial dysfunction in SLE patients were discussed.
Abstract
Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disease with multiple organ involvement. This entity is associated with accelerated atherosclerosis and increased risk of cardiovascular diseases. Endothelial dysfunction represents a key step in the initiation and maintenance of atherosclerosis and may serve as a marker for future risk of cardiovascular events. Many factors, including circulating inflammatory cytokines, reactive oxygen species, low density lipoprotein, autoantibodies, vascular endothelial growth factor, circulating endothelial cells and von Willebrand factor may activate endothelial cells, leading to impaired vascular relaxation increased leukocyte adhesion, increased endothelial permeability and generation of a pro-thrombotic state. In this paper potential mechanism of endothelial dysfunction in SLE patients were discussed.
Keywords
lupus erythematosus; vascular endothelium; endothelial dysfunction
Title
Causes of the endothelial disfunction in systemic lupus erythematosus. Endothelial disfunction markers
Journal
Issue
Article type
Review paper
Pages
102-104
Published online
2016-11-23
Page views
583
Article views/downloads
5947
Bibliographic record
Forum Dermatologicum 2016;2(3):102-104.
Keywords
lupus erythematosus
vascular endothelium
endothelial dysfunction
Authors
Kamila Karolina Tokarska
Anna Woźniacka