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Therapeutic difficulties in a patient with pemphigus foliaceus
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Abstract
A case of 49-year old male, who manifested extensive, varied in size, erythematous skin lesions with shallow erosions, on trunk. A diagnosis of pemphigus foliaceus was stated upon clinical manifestations, direct immunofluorescence examination, indirect immunofluorescence examination and enzyme-linked immunosorbant assay for desmoglein 1 antibodies in serum. The patient was initially treated with prednisone and azathioprine, according to consensus of Polish Dermatological Society. After two weeks of treatment, the patient was hospitalized in surgery ward, due to escalated stomach-ache. In the ward, esophageal mycosis and inflammation of the mucuous membrane of the stomach were observed and considered as treatment’s complications. Due to adverse events observed, second line therapy was administered: cyclophosphamide and methylprednisolone (initially in pulses, than orally). Improvement in clinical manifestations was noted.
Abstract
A case of 49-year old male, who manifested extensive, varied in size, erythematous skin lesions with shallow erosions, on trunk. A diagnosis of pemphigus foliaceus was stated upon clinical manifestations, direct immunofluorescence examination, indirect immunofluorescence examination and enzyme-linked immunosorbant assay for desmoglein 1 antibodies in serum. The patient was initially treated with prednisone and azathioprine, according to consensus of Polish Dermatological Society. After two weeks of treatment, the patient was hospitalized in surgery ward, due to escalated stomach-ache. In the ward, esophageal mycosis and inflammation of the mucuous membrane of the stomach were observed and considered as treatment’s complications. Due to adverse events observed, second line therapy was administered: cyclophosphamide and methylprednisolone (initially in pulses, than orally). Improvement in clinical manifestations was noted.
Keywords
pemphigus, pemphigus foliaceus
About this articleTitle
Therapeutic difficulties in a patient with pemphigus foliaceus
Journal
Issue
Article type
Case report
Pages
41-43
Published online
2016-05-09
Page views
578
Article views/downloads
8814
Bibliographic record
Forum Dermatologicum 2016;2(1):41-43.
Keywords
pemphigus
pemphigus foliaceus
Authors
Katarzyna Juczyńska
Anna Woźniacka
Agnieszka Żebrowska
Elżbieta Waszczykowska
