Vol 8, No 1 (2022)
Review paper
Published online: 2022-04-01
Page views 1899
Article views/downloads 16
Get Citation

Connect on Social Media

Connect on Social Media

Mikroskopia konfokalna jako uzupełnienie badania dermoskopowego w codziennej praktyce dermatologicznej

Monika Słowińska1, Grażyna Kamińska-Winciorek2, Iwona Czarnecka1, Elwira Paluchowska1, Witold Owczarek1
Forum Dermatologicum 2022;8(1):11-16.

Abstract

Refleksyjna mikroskopia konfokalna (reflectance confocal microscopy, RCM) jest nieinwazyjną metodą diagnostyczną in vivo stosowaną komplementarnie do badania dermoskopowego i klinicznego. Znalazła zastosowanie w diagnostyce różnicowej zmian nowotworowych, wybranych chorób zapalnych oraz infekcyjnych i nienowotworowych zaburzeń barwnikowych skóry. Istotnym wsparciem dla klinicysty są liczne algorytmy RCM, charakteryzujące się wysokimi wskaźnikami czułości i swoistości w rozpoznawaniu czerniaka. Liczne badania wykazały, że RCM zwiększa dokładność diagnostyczną, oszczędza wielu niepotrzebnych wycięć chirurgicznych i może być stosowana w celu monitorowania leczenia lub progresji choroby. W oparciu o przegląd piśmiennictwa artykuł podsumowuje aktualne możliwości zastosowania RCM w praktyce klinicznej z uwzględnieniem ograniczeń metody.

Article available in PDF format

Add to basket: 49.00 PLN

Aready have access?

References

  1. González S, Swindells K, Rajadhyaksha M, et al. Changing paradigms in dermatology: confocal microscopy in clinical and surgical dermatology. Clin Dermatol. 2003; 21(5): 359–369.
  2. Shahriari N, Grant-Kels JM, Rabinovitz H, et al. Reflectance confocal microscopy: Principles, basic terminology, clinical indications, limitations, and practical considerations. J Am Acad Dermatol. 2021; 84(1): 1–14.
  3. Waddell A, Star P, Guitera P. Advances in the use of reflectance confocal microscopy in melanoma. Melanoma Manag. 2018; 5(1): MMT04.
  4. Langley RG, Rajadhyaksha M, Dwyer PJ, et al. Confocal scanning laser microscopy of benign and malignant melanocytic skin lesions in vivo. J Am Acad Dermatol. 2001; 45(3): 365–376.
  5. Marghoob AA, Charles CA, Busam KJ, et al. Melanoma or pigmented basal cell carcinoma: a clinical-pathologic correlation with dermoscopy, in vivo confocal scanning laser microscopy, and routine histology. Skin Res Technol. 2002; 8(4): 282–287.
  6. Sauermann K, Gambichler T, Wilmert M, et al. Investigation of basal cell carcinoma [correction of carcionoma] by confocal laser scanning microscopy in vivo. Skin Res Technol. 2002; 8(3): 141–147.
  7. Rishpon A, Kim N, Scope A, et al. Reflectance confocal microscopy criteria for squamous cell carcinomas and actinic keratoses. Arch Dermatol. 2009; 145(7): 766–772.
  8. Aghassi D, Anderson RR, González S. Confocal laser microscopic imaging of actinic keratoses in vivo: a preliminary report. J Am Acad Dermatol. 2000; 43(1 Pt 1): 42–48.
  9. Shahriari N, Grant-Kels JM, Rabinovitz H, et al. Reflectance confocal microscopy: Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathologic correlates of key confocal criteria, and diagnostic algorithms. J Am Acad Dermatol. 2021; 84(1): 17–31.
  10. Franceschini C, Persechino F, Ardigò M. In Vivo Reflectance Confocal Microscopy in General Dermatology: How to Choose the Right Indication. Dermatol Pract Concept. 2020; 10(2): e2020032.
  11. Gómez-Martín I, Moreno S, Andrades-López E, et al. Histopathologic and Immunohistochemical Correlates of Confocal Descriptors in Pigmented Facial Macules on Photodamaged Skin. JAMA Dermatol. 2017; 153(8): 771–780.
  12. de Carvalho N, Farnetani F, Ciardo S, et al. Reflectance confocal microscopy correlates of dermoscopic patterns of facial lesions help to discriminate lentigo maligna from pigmented nonmelanocytic macules. Br J Dermatol. 2015; 173(1): 128–133.
  13. Grazziotin TC, Cota C, Buffon RB, et al. Preliminary evaluation of in vivo reflectance confocal microscopy features of Kaposi's sarcoma. Dermatology. 2010; 220(4): 346–354.
  14. Villani A, Scalvenzi M, Peduto T, et al. Dermoscopy and reflectance confocal microscopy of Kaposi's sarcoma: an overview. J Eur Acad Dermatol Venereol. 2022; 36(4): e272–e274.
  15. Guitera P, Scolyer RA, Gill M, et al. Reflectance confocal microscopy for diagnosis of mammary and extramammary Paget's disease. J Eur Acad Dermatol Venereol. 2013; 27(1): e24–e29.
  16. Yélamos O, Hibler BP, Cordova M, et al. Handheld Reflectance Confocal Microscopy for the Detection of Recurrent Extramammary Paget Disease. JAMA Dermatol. 2017; 153(7): 689–693.
  17. Ozdemir F, Turk BG, Yaman B, et al. Reflectance confocal microscopy of mammary Paget disease. Dermatol Pract Concept. 2017; 7(4): 75–80.
  18. Wu M, Huang L, Lu X, et al. Utility of photodynamic diagnosis plus reflectance confocal microscopy in detecting the margins of extramammary Paget disease. Indian J Dermatol Venereol Leprol. 2021; 87(2): 207–213.
  19. Navarrete-Dechent C, Aleissa S, Cordova M, et al. Treatment of Extramammary Paget Disease and the Role of Reflectance Confocal Microscopy: A Prospective Study. Dermatol Surg. 2021; 47(4): 473–479.
  20. Melhoranse Gouveia B, Wells J, Kim J, et al. Reflectance confocal microscopy as a new diagnostic tool in transformed mycosis fungoides. Australas J Dermatol. 2020; 61(3): e358–e363.
  21. Liu H, Wang L, Lin Y, et al. The Differential Diagnosis of Hypopigmented Mycosis Fungoides and Vitiligo With Reflectance Confocal Microscopy: A Preliminary Study. Front Med (Lausanne). 2020; 7: 609404.
  22. Melhoranse Gouveia B, Wells J, Kim J, et al. Reflectance confocal microscopy role in mycosis fungoides follow-up. Skin Res Technol. 2021; 27(3): 414–421.
  23. Fabbrocini G, Mazzella C, Cantelli M, et al. Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides. Skin Appendage Disord. 2018; 4(2): 118–121.
  24. Yeager DG, Noor O, Rao BK. Reflectance confocal microscopy as a first-line diagnostic technique for mycosis fungoides. Cutis. 2018; 102(1): 56–58.
  25. Broggi G, Lacarrubba F, Verzì AE, et al. Confocal microscopy features of patch-stage mycosis fungoides and their correlation with horizontal histopathological sections. A case series. J Cutan Pathol. 2019; 46(2): 163–165.
  26. Mancebo SE, Cordova M, Myskowski PL, et al. Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies. J Cutan Pathol. 2016; 43(6): 505–515.
  27. Nguyen KP, Peppelman M, Hoogedoorn L, et al. The current role of in vivo reflectance confocal microscopy within the continuum of actinic keratosis and squamous cell carcinoma: a systematic review. Eur J Dermatol. 2016; 26(6): 549–565.
  28. Xiong YD, Ma S, Li X, et al. A meta-analysis of reflectance confocal microscopy for the diagnosis of malignant skin tumours. J Eur Acad Dermatol Venereol. 2016; 30(8): 1295–1302.
  29. Yélamos O, Manubens E, Jain M, et al. Improvement of diagnostic confidence and management of equivocal skin lesions by integration of reflectance confocal microscopy in daily practice: Prospective study in 2 referral skin cancer centers. J Am Acad Dermatol. 2020; 83(4): 1057–1063.
  30. Pellacani G, Pepe P, Casari A, et al. Reflectance confocal microscopy as a second-level examination in skin oncology improves diagnostic accuracy and saves unnecessary excisions: a longitudinal prospective study. Br J Dermatol. 2014; 171(5): 1044–1051.
  31. Alarcon I, Carrera C, Palou J, et al. Impact of in vivo reflectance confocal microscopy on the number needed to treat melanoma in doubtful lesions. Br J Dermatol. 2014; 170(4): 802–808.
  32. Stanganelli I, Longo C, Mazzoni L, et al. Integration of reflectance confocal microscopy in sequential dermoscopy follow-up improves melanoma detection accuracy. Br J Dermatol. 2015; 172(2): 365–371.
  33. González S, González E, White WM, et al. Allergic contact dermatitis: correlation of in vivo confocal imaging to routine histology. J Am Acad Dermatol. 1999; 40(5 Pt 1): 708–713.
  34. Hoogedoorn L, Peppelman M, van de Kerkhof PCM, et al. The value of in vivo reflectance confocal microscopy in the diagnosis and monitoring of inflammatory and infectious skin diseases: a systematic review. Br J Dermatol. 2015; 172(5): 1222–1248.
  35. Ardigo M, Longo C, Gonzalez S, et al. International Confocal Working Group Inflammatory Skin Diseases Project. Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis. Br J Dermatol. 2016; 175(2): 364–374.
  36. Ardigo M, Agozzino M, Franceschini C, et al. Reflectance Confocal Microscopy Algorithms for Inflammatory and Hair Diseases. Dermatol Clin. 2016; 34(4): 487–496.
  37. Ardigò M, Agozzino M, Franceschini C, et al. Reflectance confocal microscopy for scarring and non-scarring alopecia real-time assessment. Arch Dermatol Res. 2016; 308(5): 309–318.
  38. Ilie MA, Caruntu C, Lixandru D, et al. confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions. Exp Ther Med. 2019; 17(2): 1004–1011.
  39. Lu Q, Jiang G. Progress in the application of reflectance confocal microscopy in dermatology. Postepy Dermatol Alergol. 2021; 38(5): 709–715.
  40. Broggi G, Verzì A, Lacarrubba F, et al. Horizontal Histopathology Correlation with In Vivo Reflectance Confocal Microscopy in Inflammatory Skin Diseases: A Review. Appl. Sci. 2022; 12(4): 1930.
  41. Cinotti E, Fouilloux B, Perrot JL, et al. Confocal microscopy for healthy and pathological nail. J Eur Acad Dermatol Venereol. 2014; 28(7): 853–858.
  42. Pogorzelska-Antkowiak A, Corneli P, Zalaudek I, et al. Characteristics of granuloma annulare in reflectance confocal microscopy. Dermatol Ther. 2021; 34(4): e15021.
  43. Pogorzelska-Antkowiak A, Corneli P, Agozzino M. Features of necrobiosis lipoidica in reflectance confocal microscopy. Australas J Dermatol. 2021; 62(2): e359–e361.
  44. Pasquali P, Gonzalez S, Fortuño A, et al. In-vivo assessment of a case of cutaneous sarcoidosis using reflectance confocal microscopy. An Bras Dermatol. 2019; 94(1): 93–95.
  45. Segurado-Miravalles G, Fernández-Nieto D, Suárez-Valle A, et al. Reflectance confocal microscopy of cutaneous sarcoidosis. Skin Res Technol. 2021; 27(5): 980–981.
  46. Lim SS, Ohn J, Mun JH. Diagnosis of Onychomycosis: From Conventional Techniques and Dermoscopy to Artificial Intelligence. Front Med (Lausanne). 2021; 8: 637216.
  47. Uva L, Leal-Filipe P, Soares-de-Almeida L, et al. Reflectance confocal microscopy for the diagnosis of tinea nigra. Clin Exp Dermatol. 2018; 43(3): 332–334.
  48. Nori S, Rius-Díaz F, Cuevas J, et al. Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. J Am Acad Dermatol. 2004; 51(6): 923–930.
  49. Woliner-van der Weg W, Peppelman M, Elshot YS, et al. Biopsy outperforms reflectance confocal microscopy in diagnosing and subtyping basal cell carcinoma: results and experiences from a randomized controlled multicentre trial. Br J Dermatol. 2021; 184(4): 663–671.
  50. Longo C, Moscarella E, Argenziano G, et al. Reflectance confocal microscopy in the diagnosis of solitary pink skin tumours: review of diagnostic clues. Br J Dermatol. 2015; 173(1): 31–41.
  51. Peppelman M, Nguyen KP, Hoogedoorn L, et al. Reflectance confocal microscopy: non-invasive distinction between actinic keratosis and squamous cell carcinoma. J Eur Acad Dermatol Venereol. 2015; 29(7): 1302–1309.