Vol 8, No 2 (2022)
Review paper
Published online: 2022-04-25
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Herbal remedies in the topical treatment of psoriasis

Paweł Głuszak1, Nina Kurkowska1, Maria Kiczek1, Jan Mokrzycki1, Jakub Goch1, Igor Piotrowski23
Forum Dermatologicum 2022;8(2):76-85.

Abstract

Psoriasis is a relatively frequent, chronic, inflammatory skin disease. Estimated prevalence of psoriasis in the Polish population is about3%. Topical treatment is successfully used in all types of psoriasis. It is the main therapy of mild psoriasis and adjuvant treatment in advanced psoriasis. This disease is characterized by high incidence of recurrence and varied treatment responses. Patients unsatisfied with the efficacy of standard topical treatment often reach for alternative methods. In this article we focus on herbal constituents potentially useful in topical treatment of psoriasis. This review encompasses medicinal raw materials, their active ingredients, potential molecular mechanisms and clinical trials in order to estimate their effectiveness and safety.

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References

  1. Menter A. Psoriasis and psoriatic arthritis overview. Am J Manag Care. 2016; 22(8 Suppl): s216–s224.
  2. Kostecka A., Epidemiologia łuszczycy w Polsce. https://www.termedia.pl/dermatologia/Epidemiologia-luszczycy-w-Polsce,32867.html (26.01.2022).
  3. Milavec-Puretić V, Mance M, Ceović R, et al. Lipozenčić J. Drug induced psoriasis Acta Dermatovenerol Croat 2011;19(1):39-42 PMID. ; 21489366.
  4. Menter A, Gottlieb A, Feldman SR, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008; 58(5): 826–850.
  5. Coates LC, Helliwell PS. Psoriatic arthritis: state of the art review. Clin Med (Lond). 2017; 17(1): 65–70.
  6. Masson W, Lobo M, Molinero G. Psoriasis and Cardiovascular Risk: A Comprehensive Review. Adv Ther. 2020; 37(5): 2017–2033.
  7. Yavuz Daglioglu EB, Cadirci D, Aksoy M. Effects of disease severity on quality of life in patients with psoriasis. Dermatol Ther. 2020; 33(6): e14422.
  8. Szepietowski J, Adamski Z, Chodorowska G, et al. Leczenie łuszczycy zwyczajnej – rekomendacje ekspertów Polskiego Towarzystwa Dermatologicznego. Część I: łuszczyca łagodna, łuszczyca wieku dziecięcego . Przegl Dermatol. 2012; 99: 83–96.
  9. Fleischer AB, Feldman SR, Rapp SR, et al. Alternative therapies commonly used within a population of patients with psoriasis. Cutis. 1996; 58(3): 216–220.
  10. National Center for Complementary and Alternative Medicine Website. J Med Libr Assoc. 2005; 93(3): 410–412.
  11. Miroddi M, Navarra M, Calapai F, et al. Review of Clinical Pharmacology of Aloe vera L. in the Treatment of Psoriasis. Phytother Res. 2015; 29(5): 648–655.
  12. Leng H, Pu Li, Xu L, et al. Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF‑α‑induced HaCaT cell proliferation and the underlying mechanism in psoriasis. Mol Med Rep. 2018; 18(3): 3537–3543.
  13. Syed TA, Ahmad SA, Holt AH, et al. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health. 1996; 1(4): 505–509.
  14. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J Eur Acad Dermatol Venereol. 2010; 24(2): 168–172.
  15. El-Gammal E, Nardo VDi, Daaboul F, et al. Apitherapy as a New Approach in Treatment of Palmoplantar Psoriasis. Open Access Maced J Med Sci. 2018; 6(6): 1059–1061.
  16. Dabholkar N, Rapalli VK, Singhvi G. Potential herbal constituents for psoriasis treatment as protective and effective therapy. Phytother Res. 2020 [Epub ahead of print].
  17. Shathirapathiy G, Nair P, Hyndavi S. Effect of starch-fortified turmeric bath on psoriasis: a parallel randomised controlled trial. Focus on Alternative and Complementary Therapies. 2015; 20(3-4): 125–129.
  18. Sarafian G, Afshar M, Mansouri P, et al. Topical Turmeric Microemulgel in the Management of Plaque Psoriasis; A Clinical Evaluation. Iran J Pharm Res. 2015; 14(3): 865–876.
  19. Bahraini P, Rajabi M, Mansouri P, et al. Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial. J Cosmet Dermatol. 2018; 17(3): 461–466.
  20. Sun L, Liu Z, Wang L, et al. Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel. J Control Release. 2017; 254: 44–54.
  21. Mousa AM, Alhumaydhi FA, Abdellatif AAH, et al. Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects. Cutan Ocul Toxicol. 2021 [Epub ahead of print]: 1–10.
  22. Janeczek M, Moy L, Lake EP, et al. Review of the Efficacy and Safety of Topical Mahonia aquifolium for the Treatment of Psoriasis and Atopic Dermatitis. J Clin Aesthet Dermatol. 2018; 11(12): 42–47.
  23. Bernstein S, Donsky H, Gulliver W, et al. Treatment of mild to moderate psoriasis with Reliéva, a Mahonia aquifolium extract--a double-blind, placebo-controlled study. Am J Ther. 2006; 13(2): 121–126.
  24. Gulliver WP, Donsky HJ. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Am J Ther. 2005; 12(5): 398–406.
  25. Srinivasan K. Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review. Crit Rev Food Sci Nutr. 2016; 56(9): 1488–1500.
  26. Chan T, Lee MS, Huang WC, et al. Topical TRPV1 agonist capsaicin restricts imiquimod-induced cutaneous inflammation. Journal of the American Academy of Dermatology. 2019; 81(4): AB288.
  27. Bernstein J, Parish L, Rapaport M, et al. Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Dermatol. 1986; 15(3): 504–507.
  28. Ellis C, Berberian B, Sulica V, et al. A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol. 1993; 29(3): 438–442.
  29. Wei WL, Zeng R, Gu CM, et al. Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. J Ethnopharmacol. 2016; 190: 116–141.
  30. Wei WL, Zeng R, Gu CM, et al. Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. J Ethnopharmacol. 2016; 190: 116–141.
  31. Rathod DG, Muneer H, Masood S. Phototherapy Available from: https://www.ncbi.nlm.nih.gov/books/NBK563140/. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. [Updated 2021 Dec 20].
  32. Melough MM, Cho E, Chun OK. Furocoumarins: A review of biochemical activities, dietary sources and intake, and potential health risks. Food Chem Toxicol. 2018; 113: 99–107.
  33. Zhang GW. [Treatment of psoriasis by photochemotherapy: a comparison between the photosensitizing capsule of Angelica dahurica and 8-MOP]. Zhonghua Yi Xue Za Zhi. 1983; 63(1): 16–19.
  34. Rout SK, Tripathy BC, Kar B. Natural Green Alternatives to Psoriasis Treatment– A Review. Glob J of P & P Scien. 2017; 04(1): 17–23.
  35. Hwang JR, Cartron AM, Khachemoune A. A review of Nigella sativa plant-based therapy in dermatology. Int J Dermatol. 2021; 60(12): e493–e499.
  36. Fatima Shad K, Soubra W, Cordato DJ. The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases. Clin Exp Pharmacol Physiol. 2021; 48(11): 1445–1453.
  37. Dwarampudi LP, Palaniswamy D, Nithyanantham M, et al. Antipsoriatic activity and cytotoxicity of ethanolic extract of Nigella sativa seeds. Pharmacogn Mag. 2012; 8(32): 268–272.
  38. Wölfle U, Seelinger G, Schempp CM. Topical application of St. John's wort (Hypericum perforatum). Planta Med. 2014; 80(2-3): 109–120.
  39. Najafizadeh P, Hashemian F, Mansouri P, et al. The evaluation of the clinical effect of topical St Johns wort (Hypericum perforatum L.) in plaque type psoriasis vulgaris: a pilot study. Australas J Dermatol. 2012; 53(2): 131–135.
  40. Dabholkar N, Rapalli VK, Singhvi G. Potential herbal constituents for psoriasis treatment as protective and effective therapy. Phytother Res. 2020 [Epub ahead of print].
  41. Pazyar N, Yaghoobi R. Tea tree oil as a novel antipsoriasis weapon. Skin Pharmacol Physiol. 2012; 25(3): 162–163.
  42. Sharifi-Rad J, Salehi B, Varoni EM, et al. Plants of the Melaleuca Genus as Antimicrobial Agents: From Farm to Pharmacy. Phytother Res. 2017; 31(10): 1475–1494.
  43. Cheng HM, Kuo YZ, Chang CY, et al. The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression. J Ethnopharmacol. 2020; 255: 112760.
  44. Lin YK, Wong WR, Chang YC, et al. The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis. Dermatology. 2007; 214(2): 155–161.
  45. Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2015; 5(1): 21–26.
  46. Schulz HU, Schürer M, Bässler D, et al. Investigation of the effect on photosensitivity following multiple oral dosing of two different hypericum extracts in healthy men. Arzneimittelforschung. 2006; 56(3): 212–221.