Vol 8, No 2 (2022)
Review paper
Published online: 2022-04-04
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Biologic treatment for hidradenitis suppurativa — review of current literature

Miłosz Lewandowski1, Zuzanna Świerczewska1, Wioletta Barańska-Rybak1
Forum Dermatologicum 2022;8(2):69-75.

Abstract

Hidradenitis suppurativa (HS) is a chronic, debilitating, recurring inflammatory skin condition defined by the presence of severe, persistent, painful nodules, abscesses, and fistulas in the skin folds of the axilla, groin, gluteal, and perianal regions. Hidradenitis suppurativa’s pathophysiology is still not completely known however, it is presently thought to be an immune-mediated inflammatory condition. The selection of the proper therapy is highly crucial in these patients due to the severe decline in their quality of life and the delayed beginning of treatment. Even though hidradenitis suppurativa offers a variety of therapeutic choices, no universally effective therapy has been discovered. All of the recommendations underline the importance of a multidisciplinary approach to the condition. Biologic therapy is recommended by guidelines as a therapy in moderate to severe HS. Currently, adalimumab is the only biologic drug registered by Food and Drug Administration in acne inversa treatment. Despite this fact, recommendations or clinical trials described the other biologic drugs like infliximab, anakinra, or ustekinumab to be also potentially effective and safe in hidradenitis suppurativa treatment. The aim of this article is to review the literature on the biological treatment used in the treatment of acne inversa.

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