Vol 7, No 1 (2021)
Case report
Published online: 2021-03-17
Page views 395
Article views/downloads 35
Get Citation

Connect on Social Media

Connect on Social Media

Primary cutaneous T cel lymphoma in a pregnant woman — a therapeutic challenge

Anna Ciesielka1, Paweł Plata2, Katarzyna Kosior3, Adam Reich4
Forum Dermatologicum 2021;7(1):17-22.


Primary cutaneous lymphomas represent a heterogeneous group of lymphoproliferative disorders. Here, we have demonstrated a case of the primary cutaneous T-cell lymphoma (CTCL) in a 28-year-old pregnant woman. The patient is demonstrated because of aggressive clinical course, and therapeutic difficulties of CTCL during pregnancy. CTCL are a group of rarely occurring neoplasms and the presence of CTCL during pregnancy can be an additional diagnostic and therapeutic challenge that needs multidisciplinary healthcare approach.

Article available in PDF format

Add to basket: 49.00 PLN

Aready have access?


  1. Sokołowska-Wojdyło M. Pierwotne chłoniaki skóry. In: Krzakowski M, Warzocha K. ed. Zalecenia postępowania diagnostyczno-terapeutycznego w nowotworach złośliwych. Tom II. Via Medica, Gdańsk 2013: 948–968.
  2. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127(20): 2375–2390.
  3. Jaffe E, Swerdlow SHCE, Campo E, Pileri, S, Thiele J, Harris N, Stein HT, Wardiman JW. WHO classification of tumours of the haematopoietic and lymphoid tissues. World Health Organisation, Genewa 2008.
  4. Öztürk M, Dede M, Çoksüer H, et al. Mycosis fungoides and pregnancy: a case report. Kocatepe Med J . 2012; 13: 43–46.
  5. Fatemi Naeini F, Abtahi-Naeini B, Najafian J, et al. Correlation between mycosis fungoides and pregnancy. Saudi Med J. 2016; 37(9): 968–972.
  6. Naeini FF, Najafian J, Nilforoushzadeh M. CD30+ Large Cell Transformation of Mycosis Fungoides During Pregnancy. Indian J Dermatol. 2013; 58(2): 160.
  7. Vergier B, de Mu, Beylot-Barry M, et al. Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. French Study Group of Cutaneious Lymphomas. Blood. 2000; 95: 2212–2218.
  8. Diamandidou E, Colome-Grimmer M, Fayad L, et al. Transformation of mycosis fungoides/Sezary syndrome: clinical characteristics and prognosis. Blood. 1998; 92(4): 1150–1159.
  9. Amitay-Layish I, David M, Kafri B, et al. Early-stage mycosis fungoides, parapsoriasis en plaque, and pregnancy. Int J Dermatol. 2007; 46(2): 160–165.
  10. Castelo-Branco C, Torné A, Cararach V, et al. Mycosis fungoides and pregnancy. Oncol Rep. 2001; 8(1): 197–199.
  11. Echols KT, Gilles JM, Diro M. Mycosis fungoides in pregnancy: remission after treatment with f -interferon in a case refractory to conventional therapy: a case report. J Matern Fetal Med. 2001; 10(1): 68–70.
  12. Wilcox RA. Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol. 2017; 92(10): 1085–1102.
  13. Agar NS, Wedgeworth E, Crichton S, et al. Survival outcomes and prognostic factors in mycosis fungoides/Sézary syndrome: validation of the revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer staging proposal. J Clin Oncol. 2010; 28(31): 4730–4739.
  14. Kim EJ, Hess S, Richardson SK, et al. Immunopathogenesis and therapy of cutaneous T cell lymphoma. J Clin Invest. 2005; 115(4): 798–812.
  15. Krejsgaard T, Lindahl LM, Mongan NP, et al. Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover. Semin Immunopathol. 2017; 39(3): 269–282.
  16. Litvinov IV, Cordeiro B, Fredholm S, et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines. Cell Cycle. 2014; 13(18): 2975–2982.
  17. Tancrède-Bohin E, Ionescu MA, de La Salmonière P, et al. Prognostic value of blood eosinophilia in primary cutaneous T-cell lymphomas. Arch Dermatol. 2004; 140(9): 1057–1061.
  18. La Rocca C, Carbone F, Longobardi S, et al. The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus. Immunol Lett. 2014; 162(1 Pt A): 41–48.
  19. Kwiatek M, Kwaśniewska A. Rola komórek T regulatorowych w ciąży. Post Biol Kom. 2011; 38: 395–406.
  20. Yip L, McCluskey J, Sinclair R. Immunological aspects of pregnancy. Clin Dermatol. 2006; 24(2): 84–87.
  21. Rubach M, Litwiniuk M, et al. Mądry R Cancer in pregnant women. Oncol Clin Pract. 2018; 4: 68–85.
  22. Sagan D, Semczuk A, Lampka E. Combination chemotherapy for Hodgkin's lymphoma during pregnancy: favorable outcome for mother and child. J Obstet Gynaecol Res. 2010; 36(4): 882–886.
  23. Bachanova V, Connors JM, Bachanova V. Hodgkin lymphoma in pregnancy. Curr Hematol Malig Rep. 2013; 8(3): 211–217.
  24. Pereg D, Koren G, Lishner M. The treatment of Hodgkin's and non-Hodgkin's lymphoma in pregnancy. Haematologica. 2007; 92(9): 1230–1237.
  25. Pereg D, Koren G, Lishner M. Cancer in pregnancy: gaps, challenges and solutions. Cancer Treat Rev. 2008; 34(4): 302–312.
  26. El-Hemaidi I, Robinson SE. Management of haematological malignancy in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2012; 26(1): 149–160.
  27. Avivi I, Farbstein D, Brenner B, et al. Non-Hodgkin lymphomas in pregnancy: tackling therapeutic quandaries. Blood Rev. 2014; 28(5): 213–220.
  28. Vandenbriele C, Dierickx D, Amant F, et al. The treatment of hematologic malignancies in pregnancy. Facts Views Vis Obgyn. 2010; 2(2): 74–87.
  29. Avilés A, Neri N, Nambo MJ. Hematological malignancies and pregnancy: treat or no treat during first trimester. Int J Cancer. 2012; 131: 2678–2683.
  30. Azim HA, Pavlidis N, Peccatori FA. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part II: Hematological tumors. Cancer Treat Rev. 2010; 36(2): 110–121.
  31. Evens A, Lishner M, Avivi I, et al. Hodgkin lymphoma and non-Hodgkin lymphoma. Textbook of Cancer in Pregnancy. 2017: 111–118.
  32. Froesch P, Belisario-Filho V, Zucca E. Hodgkin and non-Hodgkin lymphomas during pregnancy. Recent Results Cancer Res. 2008; 178: 111–121.