The new European League Against Rheumatism/American College of Rheumatology 2019 classification criteria for systemic lupus erythematosus
Abstract
The systemic lupus erythematosus (SLE) is an autoimmune disease which can affect almost all organs. The diagnosis of lupus is hindered by the multitude of similar clinical symptoms occurring at different time intervals, non-specific laboratory abnormalities and histopathological features that may also occur in other diseases. The presence of antibodies against self-antigens, especially antinuclear antibodies, is of great importance in the diagnostic process. Rapid diagnosis of the disease and implementation of appropriate treatment is crucial for therapeutic success and enables to prevent many complications. In 2018, new classification criteria for SLE were developed, namely EULAR/ACR 2019 criteria, which were based on the previous SLICC and ACR criteria but have been markedly modified. These criteria were divided into 7 clinical and 3 immunological domains. The preliminary criterion is at least a single confirmation of the presence of antinuclear antibodies with a titer of ≥ 1: 80, and next to achieving ≥ 10 points from pre-defined symptoms, including at least 1 criterion from the clinical domain. Only one symptom with the highest score from each domain is used for the total sum calculation.
Keywords: diagnosticscriteriadiagnosislupus erythematosus
References
- Gergianaki I, Bortoluzzi A, Bertsias G. Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2018; 32(2): 188–205.
- Fava A, Petri M. Systemic lupus erythematosus: Diagnosis and clinical management. J Autoimmun. 2019; 96: 1–13.
- Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritis Rheumatol. 2019; 78(9): 1151–1159.
- Hochberg M. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997; 40(9): 1725–1725.
- Petri M, Orbai AM, Alarcón G, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012; 64(8): 2677–2686.
- Johnson S, Brinks R, Costenbader K, et al. Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. Ann Rheum Dis. 2020; 79(10): 1333–1339.
- Batu E, Akca UK, Kısaarslan AP, et al. The performances of the ACR 1997, SLICC 2012, and EULAR/ACR 2019 classification criteria in pediatric systemic lupus erythematosus. J Rheumatol. 2020: jrheum.200871.
