Vol 6, No 4 (2020)
Special articles
Published online: 2020-12-21
Page views 6637
Article views/downloads 26
Get Citation

Connect on Social Media

Connect on Social Media

An effective duo in the topical therapy of psoriasis — a combination of calcipotriol with betamethasone dipropionate in a traditional ointment form

Aleksandra Lesiak12, Justyna Ceryn1, Magdalena Ciążyńska2
Forum Dermatologicum 2020;6(4):97-101.


Exclusive local therapy is a sufficient treatment option for most mild cases of psoriasis. It is estimated that even 70–80% of patients do not require systemic treatment or light therapy, and topical medications effectively control the symptoms of the disease. Moreover, topical medications are also an essential treatment option in addition to systemic therapy for moderate to severe psoriasis. The most common medications used in local therapy are glucocorticosteroids and vitamin D analogues. These substances show the highest efficiency among all drugs available on the market, while maintaining a favorable toxicity profile. A significant advantage of these medications is also the ease of use, which significantly affects the compliance with medical recommendations and regular use of the preparation by patients. The different mechanism of action of the two drugs makes this unique combination of calcipotriol and betamethasone dipropionate particularly effective at any stage of the pathogenesis of psoriasis. Due to their strong antiproliferative, immunomodulating and immunostatic effects, this duo is currently recommended by the Polish Dermatological Society as a first-line preparation in the local treatment of smooth skin, hands and feet. The ointment ensures rapid penetration of active substances, strongly moisturizing, reducing skin atrophy, which is an additional benefit for patients with psoriasis. The study analyzes the effectiveness, safety and mechanism of action of medications containing calcipotriol with betamethasone dipropionate in the local therapy of psoriasis in the light of current literature data, with particular emphasis on the form of ointment.

Article available in PDF format

Add to basket: 49.00 PLN

Aready have access?


  1. Parisi R, Symmons DPM, Griffiths CEM, et al. Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013; 133(2): 377–385.
  2. Reich A, Adamski Z, Chodorowska G, et al. Psoriasis. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part I: Mild psoriasis. Dermatology Review. 2018; 105(2): 225–243.
  3. Fouéré S, Adjadj L, Pawin H. How patients experience psoriasis: results from a European survey. J Eur Acad Dermatol Venereol. 2005; 19 Suppl 3: 2–6.
  4. Martin LR, Williams SL, Haskard KB, et al. The challenge of patient adherence. Ther Clin Risk Manag. 2005; 1(3): 189–199.
  5. Wissink S, van Heerde EC, vand der Burg B, et al. A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids. Mol Endocrinol. 1998; 12(3): 355–363.
  6. Vakirlis E, Kastanis A, Ioannides D. Calcipotriol/betamethasone dipropionate in the treatment of psoriasis vulgaris. Ther Clin Risk Manag. 2008; 4(1): 141–148.
  7. Simonsen L, Høy G, Didriksen E, et al. Development of a new formulation combining calcipotriol and betamethasone dipropionate in an ointment vehicle. Drug Dev Ind Pharm. 2004; 30(10): 1095–1102.
  8. Hansen J. Mixing the unmixable. Verbal communication at the Leo Satellite Symposium. 10th Congress of the European Academy of Dermatology and Venereology; Oct 10–14 Munich, 2001.
  9. Guenther L. Calcipotriol/betamethasone dipropionate: Daivobet®/Dovobet®. Therapy. 2005; 2(3): 343–348.
  10. Kaufmann R, Bibby AJ, Bissonnette R, et al. A new calcipotriol/betamethasone dipropionate formulation (Daivobet) is an effective once-daily treatment for psoriasis vulgaris. Dermatology. 2002; 205(4): 389–393.
  11. Papp KA, Guenther L, Boyden B, et al. Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis. J Am Acad Dermatol. 2003; 48(1): 48–54.
  12. Kragballe K, Noerrelund KL, Lui H, et al. Efficacy of once-daily treatment regimens with calcipotriol/betamethasone dipropionate ointment and calcipotriol ointment in psoriasis vulgaris. Br J Dermatol. 2004; 150(6): 1167–1173.
  13. Saraceno R, Andreassi L, Ayala F, et al. Efficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet) versus calcipotriol (Daivonex) in the treatment of psoriasis vulgaris: a randomized, multicentre, clinical trial. J Dermatolog Treat. 2007; 18(6): 361–365.
  14. Huang L, Li M, Huang Q. Calcipotriol betamethasone ointment in the treatment of psoriasis vulgaris: a randomized, doubleblind, active-controlled, parallel group study. Chin J Dermatol. 2009; 42: 691–694.
  15. Guenther L, Van de Kerkhof PCM, Snellman E, et al. Efficacy and safety of a new combination of calcipotriol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: a randomized, double-blind, vehicle-controlled clinical trial. Br J Dermatol. 2002; 147(2): 316–323.
  16. Douglas WS, Poulin Y, Decroix J, et al. A new calcipotriol/betamethasone formulation with rapid onset of action was superior to monotherapy with betamethasone dipropionate or calcipotriol in psoriasis vulgaris. Acta Derm Venereol. 2002; 82(2): 131–135.
  17. Feldman SR, Horn EJ, Balkrishnan R, et al. International Psoriasis Council. Psoriasis: improving adherence to topical therapy. J Am Acad Dermatol. 2008; 59(6): 1009–1016.
  18. Kragballe K, Austad J, Barnes L, et al. Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris. Dermatology. 2006; 213(4): 319–326.
  19. Vissers WH, Berends M, Muys L, et al. The effect of the combination of calcipotriol and betamethasone dipropionate versus both monotherapies on epidermal proliferation, keratinization and T-cell subsets in chronic plaque psoriasis. Exp Dermatol. 2004; 13(2): 106–112.
  20. Traulsen J, Hughes-Formella BJ. The atrophogenic potential and dermal tolerance of calcipotriol/betamethasone dipropionate ointment compared with betamethasone dipropionate ointment. Dermatology. 2003; 207(2): 166–172.