Tom 6, Nr 4 (2020)
Artykuł przeglądowy
Opublikowany online: 2020-12-01
Pobierz cytowanie

Age-related graying of the hair — a brief summary of potential mechanisms

Monika Armatys, Agata Kłosowicz, Anna Wojas-Pelc
DOI: 10.5603/FD.a2020.0017
·
Forum Dermatologicum 2020;6(4):113-116.

dostęp płatny

Tom 6, Nr 4 (2020)
Prace poglądowe
Opublikowany online: 2020-12-01

Streszczenie

Graying of the hair is one of the most eye-catching phenotypic changes related to the chronological aging. During the last decades, scientists have engaged in research that has increased our understanding of different mechanisms of aging of a hair follicle, however many aspects of this process remain unclear. Progressive hypopigmentation of the hair shaft has been associated with decrease in number of melanocytes and tyrosinase hypoactivity in the hair bulb along with the depletion of melanocyte stem cells (MSCs) in the bulge area. Pathogenesis of graying may involve oxidative damage and incompetent MSCs maintenance. Moreover, other factors such as defective melanosomal transfer as well as insufficient neuroendocrine stimulation of MSCs and melanogenesis are hypothesized to play an important role.

Streszczenie

Graying of the hair is one of the most eye-catching phenotypic changes related to the chronological aging. During the last decades, scientists have engaged in research that has increased our understanding of different mechanisms of aging of a hair follicle, however many aspects of this process remain unclear. Progressive hypopigmentation of the hair shaft has been associated with decrease in number of melanocytes and tyrosinase hypoactivity in the hair bulb along with the depletion of melanocyte stem cells (MSCs) in the bulge area. Pathogenesis of graying may involve oxidative damage and incompetent MSCs maintenance. Moreover, other factors such as defective melanosomal transfer as well as insufficient neuroendocrine stimulation of MSCs and melanogenesis are hypothesized to play an important role.

Pobierz cytowanie

Słowa kluczowe

graying; hair follicle; melanocytes

Informacje o artykule
Tytuł

Age-related graying of the hair — a brief summary of potential mechanisms

Czasopismo

Forum Dermatologicum

Numer

Tom 6, Nr 4 (2020)

Typ artykułu

Artykuł przeglądowy

Strony

113-116

Data publikacji on-line

2020-12-01

DOI

10.5603/FD.a2020.0017

Rekord bibliograficzny

Forum Dermatologicum 2020;6(4):113-116.

Słowa kluczowe

graying
hair follicle
melanocytes

Autorzy

Monika Armatys
Agata Kłosowicz
Anna Wojas-Pelc

Referencje (34)
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