Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Folia Morphologica
MENU
Shortcuts Submit an article Author Guidelines (new) Ahead Of Print Reviewers 2023

open access

Vol 79, No 2 (2020)
Original article
Submitted: 2019-06-27
Accepted: 2019-08-06
Published online: 2019-08-22
View PDF Download PDF file
Get Citation

Overview of nuclear bodies and their classification in the Terminologia Histologica

M. Muñoz123, B. Vásquez4, M. del Sol12
DOI: 10.5603/FM.a2019.0091
·
Pubmed: 31448403
·
Folia Morphol 2020;79(2):311-317.
Affiliations
  1. Centre of Excellence in Morphological and Surgical Studies, Universidad de La Frontera, Temuco, Chile
  2. Doctorate in Morphological Sciences, Universidad de La Frontera, Temuco, Chile, Temuco, Chile
  3. National Commission for Scientific and Technological Research
  4. Faculty of Health Sciences, Universidad de Tarapacá, Arica, Chile

open access

Vol 79, No 2 (2020)
ORIGINAL ARTICLES
Submitted: 2019-06-27
Accepted: 2019-08-06
Published online: 2019-08-22

Abstract

Background: Nuclear bodies (NB) are membrane-less subnuclear organelles that perform important functions in the cell, such as transcription, RNA splicing, processing and transport of ribosomal pre-RNA, epigenetic regulation, and others. The aim of the work was to analyse the classification of NB in the Terminologia Histologica (TH) and biological and bibliographical databases.

Materials and methods: The semantic structure of the Nucleoplasm section in the TH was analysed and unsystematic bibliographical search was made in the PubMed, SciELO, EMBASE databases and European Bioinformatics Institute (EMBL-EBI) biology database to identify which structures are classified as NB.

Results: It was found that the terms Corpusculum convolutum, Macula interchromatinea and Corpusculum PML are not correctly classified in the TH, since they are subordinated under the term Chromatinum and not under Corpusculum nucleare. The bibliography consulted showed that 100%, 92.6% and 81.5% of articles mentioned Corpusculum convolutum, Macula interchromatinea and Corpusculum PML, respectively as nuclear bodies.

Conclusions: It is suggested to relocate the terms Corpusculum convolutum, Macula interchromatinea and Corpusculum PML with the name of Corpusculum nucleare and the incorporation of two new entities to the Histological Terminology according to the information collected: paraspeckles and histone locus body.

Abstract

Background: Nuclear bodies (NB) are membrane-less subnuclear organelles that perform important functions in the cell, such as transcription, RNA splicing, processing and transport of ribosomal pre-RNA, epigenetic regulation, and others. The aim of the work was to analyse the classification of NB in the Terminologia Histologica (TH) and biological and bibliographical databases.

Materials and methods: The semantic structure of the Nucleoplasm section in the TH was analysed and unsystematic bibliographical search was made in the PubMed, SciELO, EMBASE databases and European Bioinformatics Institute (EMBL-EBI) biology database to identify which structures are classified as NB.

Results: It was found that the terms Corpusculum convolutum, Macula interchromatinea and Corpusculum PML are not correctly classified in the TH, since they are subordinated under the term Chromatinum and not under Corpusculum nucleare. The bibliography consulted showed that 100%, 92.6% and 81.5% of articles mentioned Corpusculum convolutum, Macula interchromatinea and Corpusculum PML, respectively as nuclear bodies.

Conclusions: It is suggested to relocate the terms Corpusculum convolutum, Macula interchromatinea and Corpusculum PML with the name of Corpusculum nucleare and the incorporation of two new entities to the Histological Terminology according to the information collected: paraspeckles and histone locus body.

Full Text:

View PDF Download PDF file
Get Citation

Keywords

nuclear bodies, Terminologia Histologica, coiled bodies, PML nuclear bodies, nuclear speckles

About this article
Title

Overview of nuclear bodies and their classification in the Terminologia Histologica

Journal

Folia Morphologica

Issue

Vol 79, No 2 (2020)

Article type

Original article

Pages

311-317

Published online

2019-08-22

Page views

1771

Article views/downloads

545

DOI

10.5603/FM.a2019.0091

Pubmed

31448403

Bibliographic record

Folia Morphol 2020;79(2):311-317.

Keywords

nuclear bodies
Terminologia Histologica
coiled bodies
PML nuclear bodies
nuclear speckles

Authors

M. Muñoz
B. Vásquez
M. del Sol

References (55)
  1. Belmont A. Dynamics of chromatin, proteins, and bodies within the cell nucleus. Curr Opin Cell Biol. 2003; 15(3): 304–310.
    CrossRefPubMed
  2. Bouteille M, Kalifat SR, Delarue J. Ultrastructural variations of nuclear bodies in human diseases. J Ultrastruct Res. 1967; 19(5-6): 474–486.
    CrossRef
  3. Brasch K, Ochs R. Nuclear bodies (NBs): A newly “rediscovered” organelle. Exp Cell Res. 1992; 202(2): 211–223.
    CrossRef
  4. Brooks RE, Siegel BV. Nuclear bodies of normal and pathological human lymph node cells: an electron microscopic study. Blood. 1967; 29: 269–275.
  5. Carmo-Fonseca M, Rino J. RNA seeds nuclear bodies. Nat Cell Biol. 2011; 13(2): 110–112.
    CrossRefPubMed
  6. Cheng Lu, Ming H, Zhu M, et al. Long noncoding RNAs as Organizers of Nuclear Architecture. Sci China Life Sci. 2016; 59(3): 236–244.
    CrossRefPubMed
  7. Chujo T, Yamazaki T, Hirose T. Architectural RNAs (arcRNAs): A class of long noncoding RNAs that function as the scaffold of nuclear bodies. Biochim Biophys Acta. 2016; 1859(1): 139–146.
    CrossRefPubMed
  8. Cotto, J., Fox, S., Morimoto, R. HSF1 granules: a novel stress-induced nuclear compartment of human cells. J. Cell Sci. 1997; 110: 2925–2934.
  9. Courchaine EM, Lu A, Neugebauer KM. Droplet organelles? EMBO J. 2016; 35(15): 1603–1612.
    CrossRefPubMed
  10. Dalh, E. The fine structure of nuclear inclusions. J Anat. 1970; 106: 255–262.
  11. Dundr M. Nuclear bodies: multifunctional companions of the genome. Curr Opinion Cell Biol. 2012; 24(3): 415–422.
    CrossRef
  12. Dundr M, Misteli T. Biogenesis of nuclear bodies. Cold Spring Harb Perspect Biol. 2010; 2(12): a000711.
    CrossRefPubMed
  13. Elliott D, Ladomery M. Molecular biology of RNA. 1st Ed. Oxford University Press, New York. 2011.
  14. Fallik N, Bar-Lavan Y, Greenshpan Y, et al. in hematopoietic stem cells. Oncotarget. 2017; 8(65): 109575–109586.
    CrossRefPubMed
  15. Fang Y, Spector DL. Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Curr Biol. 2007; 17(9): 818–823.
    CrossRefPubMed
  16. Federative International Committee on Anatomical Terminology. Terminologia Histologica. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia. 2008.
  17. Fong KW, Li Y, Wang W, et al. Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol. 2013; 203(1): 149–164.
    CrossRefPubMed
  18. Fox AH, Lam YW, Leung AKL, et al. Paraspeckles: a novel nuclear domain. Curr Biol. 2002; 12(1): 13–25.
    CrossRefPubMed
  19. Fox AH, Lamond AI. Paraspeckles. Cold Spring Harb Perspect Biol. 2010; 2(7): a000687.
    CrossRefPubMed
  20. Gadal O, Nehrbass U. Nuclear structure and intranuclear retention of premature RNAs. J Struct Biol. 2002; 140(1-3): 140–146.
    CrossRefPubMed
  21. Galganski L, Urbanek MO, Krzyzosiak WJ. Nuclear speckles: molecular organization, biological function and role in disease. Nucleic Acids Res. 2017; 45(18): 10350–10368.
    CrossRefPubMed
  22. Gall JG. Cajal bodies: the first 100 years. Annu Rev Cell Dev Biol. 2000; 16: 273–300.
    CrossRefPubMed
  23. Guo T, Fang Y. Functional organization and dynamics of the cell nucleus. Front Plant Sci. 2014; 5: 378.
    CrossRefPubMed
  24. Ip JY, Nakagawa S. Long non-coding RNAs in nuclear bodies. Dev Growth Differ. 2012; 54(1): 44–54.
    CrossRefPubMed
  25. Lallemand-Breitenbach V, de Thé H. PML nuclear bodies. Cold Spring Harb Perspect Biol. 2010; 2(5): a000661.
    CrossRefPubMed
  26. Lenser T, Weisshart K, Ulbricht T, et al. Fluorescence Fluctuation Microscopy to Reveal 3D Architecture and Function in the Cell Nucleus. Methods Cell Biol. 2010: 2–33.
    CrossRef
  27. Li L, Roy K, Katyal S, et al. Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems. Mol Biol Cell. 2006; 17(3): 1126–1140.
    CrossRefPubMed
  28. Liu Q, Dreyfuss G. A novel nuclear structure containing the survival of motor neurons protein. EMBO J. 1996; 15(14): 3555–3565.
    CrossRef
  29. Mao YS, Zhang B, Spector DL. Biogenesis and function of nuclear bodies. Trends Genet. 2011; 27(8): 295–306.
    CrossRefPubMed
  30. Marzluff WF, Wagner EJ, Duronio RJ. Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Nat Rev Genet. 2008; 9(11): 843–854.
    CrossRefPubMed
  31. Matera A. Nuclear bodies: multifaceted subdomains of the interchromatin space. Trends Cell Biol. 1999; 9(8): 302–309.
    CrossRef
  32. Matera AG, Izaguire-Sierra M, Praveen K, et al. Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? Dev Cell. 2009; 17(5): 639–647.
    CrossRefPubMed
  33. Morimoto M, Boerkoel CF. The role of nuclear bodies in gene expression and disease. Biology (Basel). 2013; 2(3): 976–1033.
    CrossRefPubMed
  34. Nizami Z, Deryusheva S, Gall JG. The Cajal body and histone locus body. Cold Spring Harb Perspect Biol. 2010; 2(7): a000653.
    CrossRefPubMed
  35. Nunes VS, Moretti NS. Nuclear subcompartments: an overview. Cell Biol Int. 2017; 41(1): 2–7.
    CrossRefPubMed
  36. Osborne CS, Eskiw CH. Where shall we meet? A role for genome organisation and nuclear sub-compartments in mediating interchromosomal interactions. J Cell Biochem. 2008; 104(5): 1553–1561.
    CrossRefPubMed
  37. Puvion E, Moyne G. In situ localization of RNA structures. In: Busch, H. The cell nucleus Nuclear particles. (Ed). Academic Pres, New York. 1981: 59–115.
  38. Rosse C. Terminologia Anatomica: Considered from the perspective of next-generation knowledge sources. Clin Anat. 2001; 14(2): 120–133, doi: 10.1002/1098-2353(200103)14:2<120::aid-ca1020>3.0.co;2-v.
  39. Sánchez-Hernández N, Prieto-Sánchez S, Moreno-Castro C, et al. Targeting proteins to RNA transcription and processing sites within the nucleus. Int J Biochem Cell Biol. 2017; 91: 194–202.
    CrossRef
  40. Sawyer I, Dundr M. Nuclear bodies. n: Lavelle, C,, Victor, J. Nuclear architecture and dynamics. (Ed). Academic Press, London. 2018: 235–256.
  41. Schul W, Groenhout B, Koberna K, et al. The RNA 3′ cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. EMBO J. 1996; 15(11): 2883–2892.
    CrossRef
  42. Shevtsov SP, Dundr M. Nucleation of nuclear bodies by RNA. Nat Cell Biol. 2011; 13(2): 167–173.
    CrossRefPubMed
  43. Sleeman JE, Trinkle-Mulcahy L. Nuclear bodies: new insights into assembly/dynamics and disease relevance. Curr Opin Cell Biol. 2014; 28: 76–83.
    CrossRefPubMed
  44. Smigová J, Juda P, Krejčí J, et al. Structural basis of polycomb bodies. Folia Biol (Praha). 2014; 60 Suppl 1: 13–20.
    PubMed
  45. Spector DL. Nuclear domains. J Cell Sci. 2001; 114: 2891–2893.
  46. Spector DL, Lamond AI. Nuclear speckles. Cold Spring Harb Perspect Biol. 2011; 3(2).
    CrossRefPubMed
  47. Staněk D, Fox AH. Nuclear bodies: news insights into structure and function. Curr Opin Cell Biol. 2017; 46: 94–101.
    CrossRefPubMed
  48. Strouboulis J, Wolffe AP. Functional compartmentalization of the nucleus. J Cell Sci. 1996; 109(Pt8): 1991–2000.
  49. Tatomer DC, Terzo E, Curry KP, et al. Nuclear bodies: Built to boost. J Cell Biol. 2016; 213(5): 509–511.
    CrossRefPubMed
  50. Torres M, Becquet D, Blanchard MP, et al. Paraspeckles as rhythmic nuclear mRNA anchorages responsible for circadian gene expression. Nucleus. 2017; 8(3): 249–254.
    CrossRefPubMed
  51. Uversky VN. Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol. 2017; 44: 18–30.
    CrossRefPubMed
  52. Wang IF, Reddy NM, Shen CKJ. Higher order arrangement of the eukaryotic nuclear bodies. Proc Natl Acad Sci U S A. 2002; 99(21): 13583–13588.
    CrossRefPubMed
  53. Woulfe J. Nuclear bodies in neurodegenerative disease. Biochim Biophys Acta. 2008; 1783(11): 2195–2206.
    CrossRefPubMed
  54. Zhu L, Brangwynne CP. Nuclear bodies: the emerging biophysics of nucleoplasmic phases. Curr Opin Cell Biol. 2015; 34: 23–30.
    CrossRefPubMed
  55. Zimber A, Nguyen QD, Gespach C. Nuclear bodies and compartments: functional roles and cellular signalling in health and disease. Cell Signal. 2004; 16(10): 1085–1104.
    CrossRefPubMed

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Grupa Via Medica, Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.: +48 58 320 94 94, faks: +48 58 320 94 60, e-mail: viamedica@viamedica.pl