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Vol 78, No 1 (2019)
Original article
Submitted: 2018-02-26
Accepted: 2018-06-18
Published online: 2018-07-06
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Analysis of corpus callosum size depending on age and sex

W. Guz12, D. Pazdan1, S. Stachyra1, F. Świętoń1, P. Poręba1, M. Bednarz1, A. Lis1, A. Kazańska1, J. Krukowska23, J. Klęba23, A. Urbanik4
DOI: 10.5603/FM.a2018.0061
·
Pubmed: 30009363
·
Folia Morphol 2019;78(1):24-32.
Affiliations
  1. Department of Electroradiology, Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Poland
  2. Clinical Department of Radiology and Diagnostic Imaging, the Clinical Voivodship Hospital No. 2, Rzeszow, Poland
  3. Unit of Human Normal Anatomy, Department of Morphological Sciences, Faculty of Medicine, University of Rzeszow, Poland
  4. Department of Radiology, Collegium Medicum, Jagiellonian University, Krakow, Poland

open access

Vol 78, No 1 (2019)
ORIGINAL ARTICLES
Submitted: 2018-02-26
Accepted: 2018-06-18
Published online: 2018-07-06

Abstract

Background: The aim of the study was to analyse changes in the size of the corpus callosum (CC) depending on age and sex and to establish the reference values of the morphometric indices of the CC in the Polish population. 

Materials and methods: The results of magnetic resonance studies of 1108 patients performed in the years 2010–2014 were analysed. Two independent radiologists evaluated cerebral images to exclude deviations from normal state. In patients divided according to sex and to 10 age groups, measurements of CC and brain dimensions were made and morphometric indices were calculated. 

Results: The results of measurements related to the following parameters: lengths of longitudinal cross-section of CC (CD), CC thickness in the narrowest place — isthmus (EF), the largest linear dimension of the brain from the frontal pole to the occipital pole (AB), the longitudinal cross-section area of the CC (A1) and cerebral cross-section area (A2) as well as CD/AB and A1/A2 ratios are summarised in 7 figures and 3 tables. 

Conclusions: It was demonstrated, that in all age groups there are statistically significant differences in the values of the analysed parameters and ratios of CC size. It was indicated, that there are no statistically significant differences between men and women in the CD, EF, and A1 parameters related to CC size, and the profiles of variations of these parameters are very similar. It was proved that the- re are statistical differences between women and men in parameters/indicators concerning of the brain size. 

Abstract

Background: The aim of the study was to analyse changes in the size of the corpus callosum (CC) depending on age and sex and to establish the reference values of the morphometric indices of the CC in the Polish population. 

Materials and methods: The results of magnetic resonance studies of 1108 patients performed in the years 2010–2014 were analysed. Two independent radiologists evaluated cerebral images to exclude deviations from normal state. In patients divided according to sex and to 10 age groups, measurements of CC and brain dimensions were made and morphometric indices were calculated. 

Results: The results of measurements related to the following parameters: lengths of longitudinal cross-section of CC (CD), CC thickness in the narrowest place — isthmus (EF), the largest linear dimension of the brain from the frontal pole to the occipital pole (AB), the longitudinal cross-section area of the CC (A1) and cerebral cross-section area (A2) as well as CD/AB and A1/A2 ratios are summarised in 7 figures and 3 tables. 

Conclusions: It was demonstrated, that in all age groups there are statistically significant differences in the values of the analysed parameters and ratios of CC size. It was indicated, that there are no statistically significant differences between men and women in the CD, EF, and A1 parameters related to CC size, and the profiles of variations of these parameters are very similar. It was proved that the- re are statistical differences between women and men in parameters/indicators concerning of the brain size. 

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Keywords

corpus callosum; magnetic resonance; morphometry; age groups; sex

About this article
Title

Analysis of corpus callosum size depending on age and sex

Journal

Folia Morphologica

Issue

Vol 78, No 1 (2019)

Article type

Original article

Pages

24-32

Published online

2018-07-06

Page views

3203

Article views/downloads

1935

DOI

10.5603/FM.a2018.0061

Pubmed

30009363

Bibliographic record

Folia Morphol 2019;78(1):24-32.

Keywords

corpus callosum
magnetic resonance
morphometry
age groups
sex

Authors

W. Guz
D. Pazdan
S. Stachyra
F. Świętoń
P. Poręba
M. Bednarz
A. Lis
A. Kazańska
J. Krukowska
J. Klęba
A. Urbanik

References (34)
  1. Allen LS, Richey MF, Chai YM, et al. Sex differences in the corpus callosum of the living human being. J Neurosci. 1991; 11(4): 933–942.
    PubMed
  2. Andronikou S, Pillay T, Gabuza L, et al. Corpus callosum thickness in children: an MR pattern-recognition approach on the midsagittal image. Pediatr Radiol. 2015; 45(2): 258–272.
    CrossRefPubMed
  3. Ardekani BA, Figarsky K, Sidtis JJ. Sexual dimorphism in the human corpus callosum: an MRI study using the OASIS brain database. Cereb Cortex. 2013; 23(10): 2514–2520.
    CrossRefPubMed
  4. Byne W, Bleier R, Houston L. Variations in human corpus callosum do not predict gender: a study using magnetic resonance imaging. Behav Neurosci. 1988; 102(2): 222–227.
    PubMed
  5. Constant D, Ruther H. Sexual dimorphism in the human corpus callosum? A comparison of methodologies. Brain Res. 1996; 727(1-2): 99–106.
    PubMed
  6. Driesem NR, Raz N. The influence of sex, age, and handedness on corpus callosum morphology : a meta-analysis. Psychobiology. 1995; 23(3): 240–247.
  7. Firat A, Tascioglu AB, Demiryurek MD, et al. Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. Surg Radiol Anat. 2014; 36(1): 47–54.
    CrossRefPubMed
  8. Franklin MS, Kraemer GW, Shelton SE, et al. Gender differences in brain volume and size of corpus callosum and amygdala of rhesus monkey measured from MRI images. Brain Res. 2000; 852(2): 263–267.
    PubMed
  9. Gazzaniga MS. Cerebral specialization and interhemispheric communication: does the corpus callosum enable the human condition? Brain. 2000; 123 ( Pt 7): 1293–1326.
    PubMed
  10. Giedd JN, Blumenthal J, Jeffries NO, et al. Development of the human corpus callosum during childhood and adolescence: a longitudinal MRI study. Prog Neuropsychopharmacol Biol Psychiatry. 1999; 23(4): 571–588.
    PubMed
  11. Gupta T, Singh B, Kapoor K, et al. Normative data of corpus callosal morphology in a North-West Indian population- an autopsy and MRI study. JNMA J Nepal Med Assoc. 2009; 48(173): 46–51.
    PubMed
  12. Hanaie R, Mohri I, Kagitani-Shimono K, et al. Abnormal corpus callosum connectivity, socio-communicative deficits, and motor deficits in children with autism spectrum disorder: a diffusion tensor imaging study. J Autism Dev Disord. 2014; 44(9): 2209–2220.
    CrossRefPubMed
  13. Jäncke L, Staiger JF, Schlaug G, et al. The relationship between corpus callosum size and forebrain volume. Cereb Cortex. 1997; 7(1): 48–56.
    PubMed
  14. Johnson SC, Farnworth T, Pinkston JB, et al. Corpus callosum surface area across the human adult life span: effect of age and gender. Brain Res Bull. 1994; 35(4): 373–377.
    PubMed
  15. Kabay SC, Gulbandilar E, Ozden H, et al. Evaluation of the size and area of the corpus callosum with the Osiris method in Alzheimer's disease. Neurodegener Dis. 2009; 6(4): 148–153.
    CrossRefPubMed
  16. Kertesz A, Polk M, Black SE, et al. Sex, handedness, and the morphometry of cerebral asymmetries on magnetic resonance imaging. Brain Res. 1990; 530(1): 40–48.
    PubMed
  17. Krupa K, Bekiesinska-Figatowska M. Congenital and acquired abnormalities of the corpus callosum: a pictorial essay. Biomed Res Int. 2013; 2013: 265619.
    CrossRefPubMed
  18. Lee BY, Sohn JH, Choi MH, et al. A volumetric study of the corpus callosum in 20s and 40s Korean people. Brain Struct Funct. 2009; 213(4-5): 463–467.
    CrossRefPubMed
  19. Luders E, Thompson PM, Toga AW. The development of the corpus callosum in the healthy human brain. J Neuroscience. 2010; 30(33): 10985–10990.
    CrossRef
  20. Mitchell TN, Free SL, Merschhemke M, et al. Reliable callosal measurement: population normative data confirm sex-related differences. AJNR Am J Neuroradiol. 2003; 24(3): 410–418.
    PubMed
  21. Mohammadi MR, Zhand P, Mortazavi Moghadam B, et al. Measurement of the corpus callosum using magnetic resonance imaging in the north of iran. Iran J Radiol. 2011; 8(4): 218–223.
    CrossRefPubMed
  22. Moreno MB, Concha L, González-Santos L, et al. Correlation between corpus callosum sub-segmental area and cognitive processes in school-age children. PLoS One. 2014; 9(8): e104549.
    CrossRefPubMed
  23. Mourgela S, Anagnostopoulou S, Sakellaropoulos A, et al. An MRI study of sex-and age-related differences in the dimensions of the corpus callosum and brain. Neuroanatomy. 2007; 6(1): 63–65.
  24. http://nodcc.org (25.08.2017).
  25. Prendergast DM, Ardekani B, Ikuta T, et al. Age and sex effects on corpus callosum morphology across the lifespan. Hum Brain Mapp. 2015; 36(7): 2691–2702.
    CrossRefPubMed
  26. Renard D, Castelnovo G, Campello C, et al. An MRI review of acquired corpus callosum lesions. J Neurol Neurosurg Psychiatry. 2014; 85(9): 1041–1048.
    CrossRefPubMed
  27. Roy E, Hague C, Forster B, et al. The corpus callosum: imaging the middle of the road. Can Assoc Radiol J. 2014; 65(2): 141–147.
    CrossRefPubMed
  28. Salat D, Ward A, Kaye JA, et al. Sex differences in the corpus callosum with aging. Neurobiol Aging. 1997; 18(2): 191–197.
    PubMed
  29. Suganthy J, Raghuram L, Antonisamy B, et al. Gender- and age-related differences in the morphology of the corpus callosum. Clin Anat. 2003; 16(5): 396–403.
    CrossRefPubMed
  30. Sullivan EV, Rosenbloom MJ, Desmond JE, et al. Sex differences in corpus callosum size: relationship to age and intracranial size. Neurobiol Aging. 2001; 22(4): 603–611.
    PubMed
  31. Tanaka-Arakawa MM, Matsui M, Tanaka C, et al. Developmental changes in the corpus callosum from infancy to early adulthood: a structural magnetic resonance imaging study. PLoS One. 2015; 10(3): e0118760.
    CrossRefPubMed
  32. Takeda S, Hirashima Y, Ikeda H, et al. Determination of indices of the corpus callosum associated with normal aging in Japanese individuals. Neuroradiology. 2003; 45(8): 513–518.
    CrossRefPubMed
  33. Weis S, Weber G, Wenger E, et al. The controversy about a sexual dimorphism of the human corpus callosum. Int J Neurosci. 1989; 47(1-2): 169–173.
    PubMed
  34. Witelson S. Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain. 1989; 112(3): 799–835.
    CrossRef

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