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A computational simulation of long-term synaptic potentiation inducing protocol processes with model of CA3 hippocampal microcircuit
Affiliations- Intrafaculty College of Medical Informatics and Biostatistics, Medical University of Gdańsk, 1 Debinki St., 80-211 Gdańsk, Poland
- Department of Periodontology and Oral Mucosa Diseases, Medical Univerity of Gdańsk, Poland
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Abstract
An experimental study of computational model of the CA3 region presents cognitive and behavioural functions the hippocampus. The main property of the CA3 region is plastic recurrent connectivity, where the connections allow it to behave as an auto-associative memory. The computer simulations showed that CA3 model performs efficient long-term synaptic potentiation (LTP) induction and high rate of sub-millisecond coincidence detection. Average frequency of the CA3 pyramidal cells model was substantially higher in simulations with LTP induction protocol than without the LTP. The entropy of pyramidal cells with LTP seemed to be significantly higher than without LTP induction protocol (p = 0.0001). There was depression of entropy, which was caused by an increase of forgetting coefficient in pyramidal cells simulations without LTP (R = –0.88, p = 0.0008), whereas such correlation did not appear in LTP simulation (p = 0.4458). Our model of CA3 hippocampal formation microcircuit biologically inspired lets you understand neurophysiologic data. (Folia Morphol 2018; 77, 2: 210–220)
Abstract
An experimental study of computational model of the CA3 region presents cognitive and behavioural functions the hippocampus. The main property of the CA3 region is plastic recurrent connectivity, where the connections allow it to behave as an auto-associative memory. The computer simulations showed that CA3 model performs efficient long-term synaptic potentiation (LTP) induction and high rate of sub-millisecond coincidence detection. Average frequency of the CA3 pyramidal cells model was substantially higher in simulations with LTP induction protocol than without the LTP. The entropy of pyramidal cells with LTP seemed to be significantly higher than without LTP induction protocol (p = 0.0001). There was depression of entropy, which was caused by an increase of forgetting coefficient in pyramidal cells simulations without LTP (R = –0.88, p = 0.0008), whereas such correlation did not appear in LTP simulation (p = 0.4458). Our model of CA3 hippocampal formation microcircuit biologically inspired lets you understand neurophysiologic data. (Folia Morphol 2018; 77, 2: 210–220)
Keywords
learning and memory, hippocampus, long-term synaptic potentiation, forgetting, theta rhythm, computer simulation
About this articleTitle
A computational simulation of long-term synaptic potentiation inducing protocol processes with model of CA3 hippocampal microcircuit
Journal
Issue
Article type
Original article
Pages
210-220
Published online
2018-05-09
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1475
Article views/downloads
1250
DOI
Pubmed
Bibliographic record
Folia Morphol 2018;77(2):210-220.
Keywords
learning and memory
hippocampus
long-term synaptic potentiation
forgetting
theta rhythm
computer simulation
Authors
D. Świetlik
J. Białowąs
A. Kusiak
D. Cichońska
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