open access

Vol 83, No 1 (2024): Folia Morphologica
Original article
Submitted: 2023-01-04
Accepted: 2023-02-14
Published online: 2023-03-22
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Mesenchymal stem cell-derived exosomes are beneficial to suppressing inflammation and promoting autophagy in intervertebral disc degeneration

Baicheng Yang1, Xinming Yang2
·
Pubmed: 36967623
·
Folia Morphol 2024;83(1):102-112.
Affiliations
  1. Hebei North University, Zhangjiakou, Hebei, China
  2. Department of Orthopaedics, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China

open access

Vol 83, No 1 (2024): Folia Morphologica
ORIGINAL ARTICLES
Submitted: 2023-01-04
Accepted: 2023-02-14
Published online: 2023-03-22

Abstract

Background: Intervertebral disc degenerative diseases is one the main causes of lumbago, and its main pathological mechanism is intervertebral disc degeneration (IDD). As shown in previous reports, mesenchymal stem cell (MSC)-exosomes can slow down or even reverse degenerated nucleus pulposus (NP) cells in IDD. Thus, we attempted to clarify the specific role of MSC-exosomes underlying IDD progression.

Materials and methods: In the present study, the harvested particles were identified as MSC-exosomes. MSC-exosomes facilitated activation of autophagy pathway in AGE-treated NP cells. MSC-exosomes repressed inflammatory response in AGE-treated NP cells. Autophagy pathway activation enhanced inflammatory response in AGE-stimulated NP cells.

Results: Mesenchymal stem cell-exosomes facilitated autophagy pathway activation and repressed inflammation in IDD rats. Autophagy inhibition exerted a protective role against inflammatory response in IDD rats.

Conclusions: In conclusion, MSC-exosomes represses inflammation via activating autophagy pathway, which provides a potential novel insight for seeking therapeutic plans of IDD.

Abstract

Background: Intervertebral disc degenerative diseases is one the main causes of lumbago, and its main pathological mechanism is intervertebral disc degeneration (IDD). As shown in previous reports, mesenchymal stem cell (MSC)-exosomes can slow down or even reverse degenerated nucleus pulposus (NP) cells in IDD. Thus, we attempted to clarify the specific role of MSC-exosomes underlying IDD progression.

Materials and methods: In the present study, the harvested particles were identified as MSC-exosomes. MSC-exosomes facilitated activation of autophagy pathway in AGE-treated NP cells. MSC-exosomes repressed inflammatory response in AGE-treated NP cells. Autophagy pathway activation enhanced inflammatory response in AGE-stimulated NP cells.

Results: Mesenchymal stem cell-exosomes facilitated autophagy pathway activation and repressed inflammation in IDD rats. Autophagy inhibition exerted a protective role against inflammatory response in IDD rats.

Conclusions: In conclusion, MSC-exosomes represses inflammation via activating autophagy pathway, which provides a potential novel insight for seeking therapeutic plans of IDD.

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Keywords

intervertebral disc degeneration, mesenchymal stem cell, exosomes, autophagy, inflammation

About this article
Title

Mesenchymal stem cell-derived exosomes are beneficial to suppressing inflammation and promoting autophagy in intervertebral disc degeneration

Journal

Folia Morphologica

Issue

Vol 83, No 1 (2024): Folia Morphologica

Article type

Original article

Pages

102-112

Published online

2023-03-22

Page views

613

Article views/downloads

592

DOI

10.5603/FM.a2023.0021

Pubmed

36967623

Bibliographic record

Folia Morphol 2024;83(1):102-112.

Keywords

intervertebral disc degeneration
mesenchymal stem cell
exosomes
autophagy
inflammation

Authors

Baicheng Yang
Xinming Yang

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