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Vol 82, No 4 (2023)
Original article
Submitted: 2022-09-17
Accepted: 2022-11-03
Published online: 2022-11-29
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Transplantation of bone marrow-derived mesenchymal stem cells ameliorated dopamine system impairment in a D-galactose-induced brain ageing in rats

G. El-Akabawy123, S. O.F. El Kersh4, L. A. Rashed5, S. N. Amin67, A. A.K. El-Sheikh8
DOI: 10.5603/FM.a2022.0097
·
Pubmed: 36472399
·
Folia Morphol 2023;82(4):841-853.
Affiliations
  1. Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, United Arab Emirates
  2. Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates
  3. Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
  4. Faculty of Medicine, Galala University, Suez, Egypt
  5. Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
  6. Department of Anatomy, Physiology, and Biochemistry, Faculty of Medicine, The Hashemite University, Zarqa, Jordan
  7. Department of Medical Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt
  8. Basic Health Sciences Department, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

open access

Vol 82, No 4 (2023)
ORIGINAL ARTICLES
Submitted: 2022-09-17
Accepted: 2022-11-03
Published online: 2022-11-29

Abstract

Background: Ageing is the primary risk factor for Parkinson’s disease. Progressive
motor and coordination decline that occurs with ageing has been linked to nigrostriatal
dysfunction. Few studies have investigated the efficacy of mesenchymal
stem cells in ameliorating the structural and functional alterations in the ageing
nigrostriatal system. This study is the first to evaluate the effects of intravenous
injection of bone marrow-derived mesenchymal stem cells (BMMSCs) in a D-galactose-
induced rat model of nigrostriatal ageing.
Materials and methods: BMMSCs were intravenously injected once every
2 weeks for 8 weeks. The transplanted cells survived, migrated to the brain, and
differentiated into dopaminergic neurones and astrocytes.
Results: BMMSC transplantation improved locomotor activity, restored dopaminergic
system function, preserved atrophic dopaminergic neurones in the substantia
nigra, exerted antioxidative effects, and restored neurotrophic factors.
Conclusions: Our findings demonstrate the efficacy of BMMSC injection in
a nigrostriatal ageing rat model, and suggest that these cells may provide an effective
therapeutic approach for the ageing nigrostriatal system.

Abstract

Background: Ageing is the primary risk factor for Parkinson’s disease. Progressive
motor and coordination decline that occurs with ageing has been linked to nigrostriatal
dysfunction. Few studies have investigated the efficacy of mesenchymal
stem cells in ameliorating the structural and functional alterations in the ageing
nigrostriatal system. This study is the first to evaluate the effects of intravenous
injection of bone marrow-derived mesenchymal stem cells (BMMSCs) in a D-galactose-
induced rat model of nigrostriatal ageing.
Materials and methods: BMMSCs were intravenously injected once every
2 weeks for 8 weeks. The transplanted cells survived, migrated to the brain, and
differentiated into dopaminergic neurones and astrocytes.
Results: BMMSC transplantation improved locomotor activity, restored dopaminergic
system function, preserved atrophic dopaminergic neurones in the substantia
nigra, exerted antioxidative effects, and restored neurotrophic factors.
Conclusions: Our findings demonstrate the efficacy of BMMSC injection in
a nigrostriatal ageing rat model, and suggest that these cells may provide an effective
therapeutic approach for the ageing nigrostriatal system.

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Keywords

bone marrow-mesenchymal stem cells, D-galactose, rat, nigrostriatal dysfunction

About this article
Title

Transplantation of bone marrow-derived mesenchymal stem cells ameliorated dopamine system impairment in a D-galactose-induced brain ageing in rats

Journal

Folia Morphologica

Issue

Vol 82, No 4 (2023)

Article type

Original article

Pages

841-853

Published online

2022-11-29

Page views

985

Article views/downloads

640

DOI

10.5603/FM.a2022.0097

Pubmed

36472399

Bibliographic record

Folia Morphol 2023;82(4):841-853.

Keywords

bone marrow-mesenchymal stem cells
D-galactose
rat
nigrostriatal dysfunction

Authors

G. El-Akabawy
S. O.F. El Kersh
L. A. Rashed
S. N. Amin
A. A.K. El-Sheikh

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