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Remodelling compartment in root cementum
, 2, 3, 3, 3, 4
Affiliations- Hard Tissues Laboratory, Faculty of Medicine, University of Coimbra, Portugal
- Internal Medicine Department II, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
- Institute of Endodontics, Faculty of Medicine, University of Coimbra, Portugal
- Institute of Orthodontics, Faculty of Medicine, University of Coimbra, Portugal
open access
Abstract
Background: Bone remodelling represents the most remarkable bone response to mechanical stress and mineral homeostasis. It is the consequence of complex highly orchestrated and tightly regulated cellular processes taking place in a specialised entity — the bone remodelling compartment (BRC).
Materials and methods: Cementum is an understudied tissue that requires more research to understand its biology, pathology, and potential for regeneration. Although analogue to bone in structure and composition distinct structural and functional differences were ascribed to each of these mineralised tissues. The precise role of cementocytes in cementum turnover is unclear but they may work the same way as osteocytes in bone remodelling, regulating the full process.
Results: Although cementum is not liable to regular physiological remodelling as bone is, pathological cases triggered by orthodontic forces or large periapical periodontitis, those lesions can acutely induce cementum remodelling. Nevertheless, the cellular mechanisms behind this particular remodelling process are yet to be identified, as its eventual involvement of specialised anatomic structures as the BRC.
Conclusions: Hypothesizing that similar cellular mechanisms underlie bone and cementum remodelling, the present work shows, for the first time, the histological evidence of a specialized remodelling compartment in dental hard tissues.
Abstract
Background: Bone remodelling represents the most remarkable bone response to mechanical stress and mineral homeostasis. It is the consequence of complex highly orchestrated and tightly regulated cellular processes taking place in a specialised entity — the bone remodelling compartment (BRC).
Materials and methods: Cementum is an understudied tissue that requires more research to understand its biology, pathology, and potential for regeneration. Although analogue to bone in structure and composition distinct structural and functional differences were ascribed to each of these mineralised tissues. The precise role of cementocytes in cementum turnover is unclear but they may work the same way as osteocytes in bone remodelling, regulating the full process.
Results: Although cementum is not liable to regular physiological remodelling as bone is, pathological cases triggered by orthodontic forces or large periapical periodontitis, those lesions can acutely induce cementum remodelling. Nevertheless, the cellular mechanisms behind this particular remodelling process are yet to be identified, as its eventual involvement of specialised anatomic structures as the BRC.
Conclusions: Hypothesizing that similar cellular mechanisms underlie bone and cementum remodelling, the present work shows, for the first time, the histological evidence of a specialized remodelling compartment in dental hard tissues.
Keywords
bone remodelling compartment, bone, cementum, cementocytes, root resorption
About this articleTitle
Remodelling compartment in root cementum
Journal
Issue
Article type
Original article
Pages
972-979
Published online
2020-11-03
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6712
Article views/downloads
1521
DOI
Pubmed
Bibliographic record
Folia Morphol 2021;80(4):972-979.
Keywords
bone remodelling compartment
bone
cementum
cementocytes
root resorption
Authors
J. F. Brochado Martins
C. F. D. Rodrigues
P. Diogo
S. Paulo
P. J. Palma
F. F. do Vale
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