open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-08-14
Submitted: 2020-06-10
Accepted: 2020-06-25
Get Citation

Is the middle cerebral artery bifurcation aneurysm affected by morphological parameters of bifurcation?

T. Benlice, A. Idil Soylu, O. Terzi, F. Uzunkaya, H. Akan
DOI: 10.5603/FM.a2020.0096
·
Pubmed: 32827308

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-08-14
Submitted: 2020-06-10
Accepted: 2020-06-25

Abstract

Aneurysm formation is a multifactorial process involving genetic, anatomical and environmental risk factors. A research focusing on the relationship between the presence of aneurysm and the morphology of the arteries will help in the pathogenesis and prediction of intracranial aneurysms. In this study, the relationship between the presence of aneurysm and various morphological parameters of aneurysm-related arteries was evaluated in patients with saccular mıddle cerebral artery (MCA) bifurcation aneurysm.

The archival images of 74 patients (62.2% women) were evaluated retrospectively. In this study, the angle between the ipsilateral MCA M1 segment and the dominant truncus (Φ1), the angle between the M1 segment and the recessive truncus (Φ2), and the bifurcation angle (Φ1 + Φ2) were compared. Bilateral internal carotid artery (ICA), MCA M1 segment, dominant and recessive truncus diameters and this diameters ratios were compared with the aneurysmal side and the contralateral side without aneurysm. When the dominant truncus, recessive truncus angles and bifurcation angle were compared, a significant difference was found on the aneurysmal side (p <0.0001). In the ROC analysis, when the bifurcation angle of 147.5 ° was accepted as the limit value, 78.4% sensitivity, 79.7% specificity, 78.4% positive predictive value and 78.7% negative predictive value were determined (AUC = 0.85).

Our study of the morphological features of arteries associated with MCA bifurcation aneurysms showed that the presence of MCA aneurysms was significantly associated with large bifurcation angles.

Abstract

Aneurysm formation is a multifactorial process involving genetic, anatomical and environmental risk factors. A research focusing on the relationship between the presence of aneurysm and the morphology of the arteries will help in the pathogenesis and prediction of intracranial aneurysms. In this study, the relationship between the presence of aneurysm and various morphological parameters of aneurysm-related arteries was evaluated in patients with saccular mıddle cerebral artery (MCA) bifurcation aneurysm.

The archival images of 74 patients (62.2% women) were evaluated retrospectively. In this study, the angle between the ipsilateral MCA M1 segment and the dominant truncus (Φ1), the angle between the M1 segment and the recessive truncus (Φ2), and the bifurcation angle (Φ1 + Φ2) were compared. Bilateral internal carotid artery (ICA), MCA M1 segment, dominant and recessive truncus diameters and this diameters ratios were compared with the aneurysmal side and the contralateral side without aneurysm. When the dominant truncus, recessive truncus angles and bifurcation angle were compared, a significant difference was found on the aneurysmal side (p <0.0001). In the ROC analysis, when the bifurcation angle of 147.5 ° was accepted as the limit value, 78.4% sensitivity, 79.7% specificity, 78.4% positive predictive value and 78.7% negative predictive value were determined (AUC = 0.85).

Our study of the morphological features of arteries associated with MCA bifurcation aneurysms showed that the presence of MCA aneurysms was significantly associated with large bifurcation angles.

Get Citation

Keywords

intracranial aneurysm, bifurcation morphology, hemodynamic changes

About this article
Title

Is the middle cerebral artery bifurcation aneurysm affected by morphological parameters of bifurcation?

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2020-08-14

DOI

10.5603/FM.a2020.0096

Pubmed

32827308

Keywords

intracranial aneurysm
bifurcation morphology
hemodynamic changes

Authors

T. Benlice
A. Idil Soylu
O. Terzi
F. Uzunkaya
H. Akan

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By  "Via Medica sp. z o.o." sp.k., Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl