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Vol 80, No 3 (2021)
Case report
Submitted: 2020-06-04
Accepted: 2020-06-29
Published online: 2020-07-21
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Carotid paragangliomas: case report and imaging review

R. A. Baz1, C. Scheau2, N. Sârbu3, D. O. Costea4, A. Dijmărescu5, P. Bordei6
DOI: 10.5603/FM.a2020.0078
·
Pubmed: 32710793
·
Folia Morphol 2021;80(3):699-706.
Affiliations
  1. Department of Radiology, “Sf. Apostol Andrei” County Hospital, Constanta, Romania
  2. Department of Physiology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  3. Department of Radiology, Faculty of Medicine and Pharmacy “Dunărea de Jos” Galati, Romania
  4. Department of Surgery, “Sf. Apostol Andrei” County Hospital, Constanta, Romania
  5. Department of Radiology, Fundeni Clinical Institute, Bucharest, Romania
  6. Department of Anatomy, Faculty of Medicine, Constanta, Romania

open access

Vol 80, No 3 (2021)
CASE REPORTS
Submitted: 2020-06-04
Accepted: 2020-06-29
Published online: 2020-07-21

Abstract

Background: Presentation of case reviews depicting the imaging characteristics of carotid paragangliomas, associated with a thorough analysis of the anatomical morphological features and the current therapeutic strategies.
Materials and methods: We present the cases of 3 patients diagnosed with carotid paragangliomas in our clinic, illustrating diagnostic imaging elements by computer tomography (CT) and magnetic resonance imaging (MRI), but also the postoperative aspect of the carotid system, with respective anatomical, clinical and surgical considerations.
Results: The imaging aspect of the carotid paragangliomas is characterised by a mass of soft tissue with intense contrast enhancement and with “salt and pepper” MRI appearance on conventional spin-echo sequences. The postoperative evolution of the patients included in the article was favourable, without any perioperative complications or signs of local tumour recurrence.
Conclusions: Carotid paragangliomas are rare, often asymptomatic tumours, but with potential for increased malignancy, which raises the need for good knowledge of the cervical region pathology as well as the features of neuroendocrine tumours. CT and MRI examinations are essential for diagnosis, staging and, implicitly, for establishing the therapeutic strategy.

Abstract

Background: Presentation of case reviews depicting the imaging characteristics of carotid paragangliomas, associated with a thorough analysis of the anatomical morphological features and the current therapeutic strategies.
Materials and methods: We present the cases of 3 patients diagnosed with carotid paragangliomas in our clinic, illustrating diagnostic imaging elements by computer tomography (CT) and magnetic resonance imaging (MRI), but also the postoperative aspect of the carotid system, with respective anatomical, clinical and surgical considerations.
Results: The imaging aspect of the carotid paragangliomas is characterised by a mass of soft tissue with intense contrast enhancement and with “salt and pepper” MRI appearance on conventional spin-echo sequences. The postoperative evolution of the patients included in the article was favourable, without any perioperative complications or signs of local tumour recurrence.
Conclusions: Carotid paragangliomas are rare, often asymptomatic tumours, but with potential for increased malignancy, which raises the need for good knowledge of the cervical region pathology as well as the features of neuroendocrine tumours. CT and MRI examinations are essential for diagnosis, staging and, implicitly, for establishing the therapeutic strategy.

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Keywords

paraganglioma, carotid body tumour, carotid arteries, diagnostic tools, imaging, therapeutic strategy

About this article
Title

Carotid paragangliomas: case report and imaging review

Journal

Folia Morphologica

Issue

Vol 80, No 3 (2021)

Article type

Case report

Pages

699-706

Published online

2020-07-21

Page views

7284

Article views/downloads

1726

DOI

10.5603/FM.a2020.0078

Pubmed

32710793

Bibliographic record

Folia Morphol 2021;80(3):699-706.

Keywords

paraganglioma
carotid body tumour
carotid arteries
diagnostic tools
imaging
therapeutic strategy

Authors

R. A. Baz
C. Scheau
N. Sârbu
D. O. Costea
A. Dijmărescu
P. Bordei

References (36)
  1. Albsoul NM, Alsmady MM, Al-Aardah MI, et al. Carotid body paraganglioma management and outcome. Eur J Sci Res. 2009; 37(4): 567–574.
  2. Arya S, Rao V, Juvekar S, et al. Carotid body tumors: objective criteria to predict the Shamblin group on MR imaging. Am J Neuroradiol. 2008; 29(7): 1349–1354.
    CrossRefPubMed
  3. Boedeker CC, Neumann HPH, Maier W, et al. Malignant head and neck paragangliomas in SDHB mutation carriers. Otolaryngol Head Neck Surg. 2007; 137(1): 126–129.
    CrossRefPubMed
  4. Carroll W, Stenson K, Stringer S. Malignant carotid body tumor. Head Neck. 2004; 26(3): 301–306.
    CrossRefPubMed
  5. Dahia PLM. Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity. Nat Rev Cancer. 2014; 14(2): 108–119.
    CrossRefPubMed
  6. Davidovic LB, Djukic VB, Vasic DM, et al. Diagnosis and treatment of carotid body paraganglioma: 21 years of experience at a clinical center of Serbia. World J Surg Oncol. 2005; 3(1): 10.
    CrossRefPubMed
  7. Davila VJ, Chang JM, Stone WM, et al. Current surgical management of carotid body tumors. J Vasc Surg. 2016; 64(6): 1703–1710.
    CrossRefPubMed
  8. Dixon JL, Atkins MD, Bohannon WT, et al. Surgical management of carotid body tumors: a 15-year single institution experience employing an interdisciplinary approach. Proc (Bayl Univ Med Cent). 2016; 29(1): 16–20.
    CrossRefPubMed
  9. Farımaz M, Çelik HH, Ergun KM, et al. The morphometry of the cavernous part of the internal carotid artery. Folia Morphol. 2019; 78(1): 54–62.
    CrossRefPubMed
  10. Fliedner SMJ, Lehnert H, Pacak K. Metastatic paraganglioma. Semin Oncol. 2010; 37(6): 627–637.
    CrossRefPubMed
  11. Gilbo P, Morris CG, Amdur RJ, et al. Radiotherapy for benign head and neck paragangliomas: a 45-year experience. Cancer. 2014; 120(23): 3738–3743.
    CrossRefPubMed
  12. Itawi SA, Buehler M, Mrak RE, et al. A unique case of carotid splaying by a cervical vagal neurofibroma and the role of neuroradiology in surgical management. Cureus. 2017; 9(9): e1658.
    CrossRefPubMed
  13. Jackson RS, Myhill JA, Padhya TA, et al. The effects of preoperative embolization on carotid body paraganglioma surgery: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2015; 153(6): 943–950.
    CrossRefPubMed
  14. Lee JH, Barich F, Karnell LH, et al. National Cancer Data Base report on malignant paragangliomas of the head and neck. Cancer. 2002; 94(3): 730–737.
    CrossRefPubMed
  15. Lee KiY, Oh YW, Noh HJ, et al. Extraadrenal paragangliomas of the body: imaging features. Am J Roentgenol. 2006; 187(2): 492–504.
    CrossRefPubMed
  16. Luna-Ortiz K, Rascon-Ortiz M, Villavicencio-Valencia V, et al. Does Shamblin's classification predict postoperative morbidity in carotid body tumors? A proposal to modify Shamblin's classification. Eur Arch Otorhinolaryngol. 2006; 263(2): 171–175.
    CrossRefPubMed
  17. Malec K, Cenda P, Brzewski P, et al. Paragangliomas of head and neck: A surgical challenge. J Craniomaxillofac Surg. 2017; 45(1): 127–130.
    CrossRefPubMed
  18. Mannelli M, Castellano M, Schiavi F, et al. Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. J Clin Endocrinol Metab. 2009; 94(5): 1541–1547.
    CrossRefPubMed
  19. McCrary HC, Babajanian E, Calquin M, et al. Characterization of malignant head and neck paragangliomas at a single institution across multiple decades. JAMA Otolaryngol Head Neck Surg. 2019; 145(7): 641–646.
    CrossRefPubMed
  20. Moore MG, Netterville JL, Mendenhall WM, et al. Head and neck paragangliomas: an update on evaluation and management. Otolaryngol Head Neck Surg. 2016; 154(4): 597–605.
    CrossRefPubMed
  21. Muhm M, Polterauer P, Gstöttner W, et al. Diagnostic and therapeutic approaches to carotid body tumors. Review of 24 patients. Arch Surg. 1997; 132(3): 279–284.
    CrossRefPubMed
  22. Obholzer RJ, Hornigold R, Connor S, et al. Classification and management of cervical paragangliomas. Ann R Coll Surg Engl. 2011; 93(8): 596–602.
    CrossRefPubMed
  23. Offergeld C, Brase C, Yaremchuk S, et al. Head and neck paragangliomas: clinical and molecular genetic classification. Clinics. 2012; 67(S1): 19–28.
    CrossRef
  24. Olsen WL, Dillon WP, Kelly WM, et al. MR imaging of paragangliomas. Am J Roentgenol. 1987; 148(1): 201–204.
    CrossRefPubMed
  25. Pacheco-Ojeda LA. Carotid body tumors: Surgical experience in 215 cases. J Craniomaxillofac Surg. 2017; 45(9): 1472–1477.
    CrossRefPubMed
  26. Rush BF. Jr. Current concepts in the treatment of carotid body tumors. Surgery. 1962; 52: 679–684.
    PubMed
  27. Shamblin WR, ReMine WH, Sheps SG, et al. Carotid body tumor (chemodectoma). Am J Surg. 1971; 122(6): 732–739.
    CrossRef
  28. Sobol SM, Dailey JC. Familial multiple cervical paragangliomas: report of a kindred and review of the literature. Otolaryngol Head Neck Surg. 1990; 102(4): 382–390.
    CrossRefPubMed
  29. Somasundar P, Krouse R, Hostetter R, et al. Paragangliomas?A decade of clinical experience. J Surg Oncol. 2000; 74(4): 286–290, doi: 10.1002/1096-9098(200008)74:4<286::aid-jso9>3.0.co;2-c.
  30. Sykes J, Ossoff R. Paragangliomas of the Head and Neck. Otolaryngol Clin North Am. 1986; 19(4): 755–767.
    CrossRef
  31. Thelen J, Bhatt AA. Multimodality imaging of paragangliomas of the head and neck. Insights Imaging. 2019; 10(1): 29.
    CrossRefPubMed
  32. van den Berg R. Imaging and management of head and neck paragangliomas. Eur Radiol. 2005; 15(7): 1310–1318.
    CrossRefPubMed
  33. West CT, Brassett C, Gaunt ME. Variations in carotid sinus anatomy and their relevance to carotid interventions. Folia Morphol. 2018; 77(4): 693–697.
    CrossRefPubMed
  34. Williams MD. Paragangliomas of the head and neck: an overview from diagnosis to genetics. Head Neck Pathol. 2017; 11(3): 278–287.
    CrossRefPubMed
  35. Woolen S, Gemmete JJ. Paragangliomas of the Head and Neck. Neuroimaging Clin N Am. 2016; 26(2): 259–278.
    CrossRefPubMed
  36. Zeitler DM, Glick J, Har-El G. Preoperative embolization in carotid body tumor surgery: is it required? Ann Otol Rhinol Laryngol. 2010; 119(5): 279–283.
    CrossRefPubMed

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