Folia Morphologica

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-03-18
Submitted: 2019-12-16
Accepted: 2020-03-02
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Ameliorating effect of pomegranate peel extract supplement against type 1 diabetes-induced hepatic changes in the rat: biochemical, morphological and ultrastructural microscopic studies

K A.J. Faddladdeen
DOI: 10.5603/FM.a2020.0034
·
Pubmed: 32207851

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-03-18
Submitted: 2019-12-16
Accepted: 2020-03-02

Abstract

Background: Diabetes mellitus could result from disorders in insulin secretion or receptors mainly characterized by hyperglycemia. Natural antioxidants including pomegranate are traditionally used as hypoglycemic agents. The present research was designed to evaluate the possible therapeutic role of Pomegranate Peel Extract (PPE) against type1 diabetic -induced hepatic biochemical and histological alteration.  

Materials and methods: Adult male Wistar rats (N= 48) were sorted into four groups: G1: control group, G2: normal rats received PPE. G3:  STZ- diabetic rats, received IP streptozotocin (55 mg/kg BW) and G4:  Diabetic rats post-treated with PPE (200 mg/kg BW/day). Effectiveness of (PPE) was assessed by measuring serum glucose, liver enzymes, and morphological features of liver tissue using light and electron microscopy.

Results: Histological examination showed degenerative necrotic changes in diabetic rat liver which were improved by post-treatment with PPE. Biochemical results confirmed microscopic morphological and ultrastructural findings.

Conclusions: PPE was       found to have a moderate therapeutic effect against a hepatic alteration in the male rats. It could be advised for diabetic patients suffering from the early alteration of liver functions.

Abstract

Background: Diabetes mellitus could result from disorders in insulin secretion or receptors mainly characterized by hyperglycemia. Natural antioxidants including pomegranate are traditionally used as hypoglycemic agents. The present research was designed to evaluate the possible therapeutic role of Pomegranate Peel Extract (PPE) against type1 diabetic -induced hepatic biochemical and histological alteration.  

Materials and methods: Adult male Wistar rats (N= 48) were sorted into four groups: G1: control group, G2: normal rats received PPE. G3:  STZ- diabetic rats, received IP streptozotocin (55 mg/kg BW) and G4:  Diabetic rats post-treated with PPE (200 mg/kg BW/day). Effectiveness of (PPE) was assessed by measuring serum glucose, liver enzymes, and morphological features of liver tissue using light and electron microscopy.

Results: Histological examination showed degenerative necrotic changes in diabetic rat liver which were improved by post-treatment with PPE. Biochemical results confirmed microscopic morphological and ultrastructural findings.

Conclusions: PPE was       found to have a moderate therapeutic effect against a hepatic alteration in the male rats. It could be advised for diabetic patients suffering from the early alteration of liver functions.

Get Citation

Keywords

pomegranate peel extract, therapeutic, streptozotocin, liver, diabetes, liver enzymes, ultrastructure

About this article
Title

Ameliorating effect of pomegranate peel extract supplement against type 1 diabetes-induced hepatic changes in the rat: biochemical, morphological and ultrastructural microscopic studies

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2020-03-18

DOI

10.5603/FM.a2020.0034

Pubmed

32207851

Keywords

pomegranate peel extract
therapeutic
streptozotocin
liver
diabetes
liver enzymes
ultrastructure

Authors

K A.J. Faddladdeen

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