Advanced search

Vol 80, No 1 (2021)
Review article
Published online: 2020-02-20

open access

View PDF Download PDF file
Page views 2390
Article views/downloads 2189
Get Citation

Connect on Social Media

Connect on Social Media

The morphology and application of stem cells in digestive system surgery

M. Pucułek1, J. Baj1, P. Portincasa2, M. Sitarz3, C. Grochowski1, E. Radzikowska4
DOI: 10.5603/FM.a2020.0024
Pubmed: 32159846
Folia Morphol 2021;80(1):13-19.

Abstract

Background: Stem cells constitute a group of cells which possess the ability to self-renew as well as the capacity to differentiate into a vast number of different cells within the human organism. Moreover, stem cells are able to undergo a potentially unlimited number of divisions and this characteristic is clinically essential. Specific fields of its application include treatment of diseases mainly in the field of haematology, orthopaedics, surgery, dentistry, and neurology.

Materials and methods: In the following work, the current knowledge concerning mechanisms of stem cell treatment in different parts of the digestive system with its diseases as well as adjacent therapy for surgery has been revised.

Results: Stem cells therapy may be used in the treatment of various diseases of different parts of the digestive system. This also applies to the end part of the digestive tract (proctological diseases) because stem cells can be used to treat fistulas. Liposuction allows more recovery of mesenchymal stem cells, compared to previous bone marrow harvesting methods. Despite the application of stem cells in the treatment of different diseases used for many years so far, the therapeutic use for the regeneration of the gastrointestinal tract is still rare and unfamiliar.

Conclusions: Regenerative medicine seems to be a promising tool in medical research, especially when insulated cells and designed biomaterials are taken into consideration. Major points of discussion include types of stem cells, their origin or differentiation for the treatment of many diseases.

Keywords: stem celldigestive system surgeryfistula

Article available in PDF format

View PDF Download PDF file

References

  1. Abdallah BM, Kassem M. The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: current status and future perspectives. J Cell Physiol. 2009; 218(1): 9–12.
    CrossRefPubMed
  2. Auxenfans C, Lequeux C, Perrusel E, et al. Adipose-derived stem cells (ASCs) as a source of endothelial cells in the reconstruction of endothelialized skin equivalents. J Tissue Eng Regen Med. 2012; 6(7): 512–518.
    CrossRefPubMed
  3. Bielefeld K, Amini-Nik S, Alman B. Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci. 2012; 70(12): 2059–2081.
    CrossRef
  4. Blumetti J, Abcarian A, Quinteros F, et al. Evolution of treatment of fistula in ano. World J Surg. 2012; 36(5): 1162–1167.
    CrossRefPubMed
  5. Bonilla-Porras AR, Velez-Pardo C, Jimenez-Del-Rio M. Fast transdifferentiation of human Wharton's jelly mesenchymal stem cells into neurospheres and nerve-like cells. J Neurosci Methods. 2017; 282: 52–60.
    CrossRefPubMed
  6. Budny A, Grochowski C, Kozłowski P, et al. Obesity as a tumour development triggering factor. Ann Agric Environ Med. 2019; 26(1): 13–23.
    CrossRefPubMed
  7. Chen Ye, Shao JZ, Xiang LX, et al. Mesenchymal stem cells: a promising candidate in regenerative medicine. Int J Biochem Cell Biol. 2008; 40(5): 815–820.
    CrossRefPubMed
  8. Cherubino M, Rubin JP, Miljkovic N, et al. Adipose-derived stem cells for wound healing applications. Ann Plast Surg. 2011; 66(2): 210–215.
    CrossRefPubMed
  9. Chulpanova DS, Kitaeva KV, Tazetdinova LG, et al. Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment. Front Pharmacol. 2018; 9: 259.
    CrossRefPubMed
  10. Dietz AB, Dozois EJ, Fletcher JG, et al. Autologous mesenchymal stem cells, applied in a bioabsorbable matrix, for treatment of perianal fistulas in patients with crohn's disease. Gastroenterology. 2017; 153(1): 59–62.e2.
    CrossRefPubMed
  11. Gapska P, Kurpisz M. Perspective in optimization of stem cell therapies for heart regeneration. Postepy Hig Med Dosw (Online). 2017; 71(0): 975–987.
    CrossRefPubMed
  12. García-Olmo D, García-Arranz M, Herreros D, et al. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum. 2005; 48(7): 1416–1423.
    CrossRefPubMed
  13. Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum. 2009; 52(1): 79–86.
    CrossRefPubMed
  14. Garcia-Olmo D, Guadalajara H, Rubio-Perez I, et al. Recurrent anal fistulae: limited surgery supported by stem cells. World J Gastroenterol. 2015; 21(11): 3330–3336.
    CrossRefPubMed
  15. Grochowski C, Blicharska E, Baj J, et al. Serum iron, magnesium, copper, and manganese levels in alcoholism: a systematic review. Molecules. 2019; 24(7).
    CrossRefPubMed
  16. Grochowski C, Litak J, Kulesza B, et al. Size and location correlations with higher rupture risk of intracranial aneurysms. J Clin Neurosci. 2018; 48: 181–184.
    CrossRefPubMed
  17. Grochowski C, Radzikowska E, Maciejewski R. Neural stem cell therapy-Brief review. Clin Neurol Neurosurg. 2018; 173: 8–14.
    CrossRefPubMed
  18. Grochowski C, Staśkiewicz G. Ultra high field TOF-MRA: A method to visualize small cerebral vessels. 7T TOF-MRA sequence parameters on different MRI scanners - Literature review. Neurol Neurochir Pol. 2017; 51(5): 411–418.
    CrossRefPubMed
  19. Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000; 97(25): 13625–13630.
    CrossRefPubMed
  20. Guadalajara H, Herreros D, De-La-Quintana P, et al. Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas. Int J Colorectal Dis. 2012; 27(5): 595–600.
    CrossRefPubMed
  21. Hall SS. Choroba na szalce. Świat Nauki. 2011; 236(4): 40–43.
  22. Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012; 21(3): 309–322.
    CrossRefPubMed
  23. Herreros MD, Garcia-Arranz M, Guadalajara H, et al. FATT Collaborative Group. Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum. 2012; 55(7): 762–772.
    CrossRefPubMed
  24. Huang GTJ, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res. 2009; 88(9): 792–806.
    CrossRefPubMed
  25. Hunziker R. Regenerative medicine. National Institutes of Health. 2010.
  26. Kmiecik B, Skotny-Krakowian A, Rybak Z. Krótki przegląd na temat komórek macierzystych. Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna. 2015; 21(1): 40–45.
  27. Kołodziejczak M, Ciesielski P. Powikłania po leczeniu ropni i przetok odbytu. Borgis - Nowa Medycyna. 2016; 3: 114–126.
  28. Koźlik M, Wójcicki P. The use of stem cells in plastic and reconstructive surgery. Adv Clin Exp Med. 2014; 23(6): 1011–1017.
    CrossRefPubMed
  29. LeBleu VS, Kalluri R. A peek into cancer-associated fibroblasts: origins, functions and translational impact. Dis Model Mech. 2018; 11(4).
    CrossRefPubMed
  30. Lenas P, Moos M, Luyten FP. Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part I: from three-dimensional cell growth to biomimetics of in vivo development. Tissue Eng Part B Rev. 2009; 15(4): 381–394.
    CrossRefPubMed
  31. Lightner AL, Wang Z, Zubair AC, et al. A Systematic Review and Meta-analysis of Mesenchymal Stem Cell Injections for the Treatment of Perianal Crohn's Disease: Progress Made and Future Directions. Dis Colon Rectum. 2018; 61(5): 629–640.
    CrossRefPubMed
  32. Lin HJ, Lin J. Seed-in-Soil: pancreatic cancer influenced by tumor microenvironment. Cancers (Basel). 2017; 9(7).
    CrossRefPubMed
  33. Mackiewicz A, Lekszycki T, Olczak-Kowalczyk D. Komórki macierzyste z miazgi zęba ludzkiego (DPSCs). Charakterystyka i możliwości zastosowania – przegląd piśmiennictwa. Borgis - Nowa Stomatologia. 2014; 4: 178–182.
  34. Mizukami A, Swiech K. Mesenchymal stromal cells: from discovery to manufacturing and commercialization. Stem Cells Int. 2018; 2018: 4083921.
    CrossRefPubMed
  35. Mohan A, Singh S. Use of fat transfer to treat a chronic, non-healing, post-radiation ulcer: a case study. J Wound Care. 2017; 26(5): 272–273.
    CrossRefPubMed
  36. Moradian Tehrani R, Verdi J, Noureddini M, et al. Mesenchymal stem cells: A new platform for targeting suicide genes in cancer. J Cell Physiol. 2018; 233(5): 3831–3845.
    CrossRefPubMed
  37. Niess H, Thomas MN, Schiergens TS, et al. Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses. Innov Surg Sci. 2016; 1(1): 19–32.
    CrossRefPubMed
  38. Occhetta P, Pigeot S, Rasponi M, et al. Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis. Proc Natl Acad Sci U S A. 2018; 115(18): 4625–4630.
    CrossRefPubMed
  39. Ortiz H, Marzo J, Ciga MA, et al. Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano. Br J Surg. 2009; 96(6): 608–612.
    CrossRefPubMed
  40. Panés J, García-Olmo D, Assche GV, et al. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial. Lancet. 2016; 388(10051): 1281–1290.
    CrossRef
  41. Piejko M, Romaniszyn M, Borowczyk-Michałowska J, et al. Cell therapy in surgical treatment of fistulas. Preliminary results. Pol Przegl Chir. 2017; 89(3): 48–51.
    PubMed
  42. Rashed L, Gharib DM, Hussein RE, et al. Combined effect of bone marrow derived mesenchymal stem cells and nitric oxide inducer on injured gastric mucosa in a rat model. Tissue Cell. 2016; 48(6): 644–652.
    CrossRefPubMed
  43. Reichenberger M, Mueller W, Schäfer A, et al. Fibrin-Embedded adipose derived stem cells enhance skin flap survival. Stem Cell Rev Rep. 2012; 8(3): 844–853.
    CrossRef
  44. Rhee KJ, Lee JIn, Eom YW. Mesenchymal stem cell-mediated effects of tumor support or suppression. Int J Mol Sci. 2015; 16(12): 30015–30033.
    CrossRefPubMed
  45. Rizvi S, Khan SA, Hallemeier CL, et al. Cholangiocarcinoma - evolving concepts and therapeutic strategies. Nat Rev Clin Oncol. 2018; 15(2): 95–111.
    CrossRefPubMed
  46. Sedgley CM, Botero TM. Dental stem cells and their sources. Dent Clin North Am. 2012; 56(3): 549–561.
    CrossRefPubMed
  47. Theodoropoulos G, Mihailidou E, Kolovos G. The role of stem cells in the treatment of anal fistulas. Digestive System Diseases. 2019: 113–135.
    CrossRef
  48. von Einem JC, Guenther C, Volk HD, et al. Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells: Results from the phase 1/2 TREAT-ME-1 trial. Int J Cancer. 2019; 145(6): 1538–1546.
    CrossRefPubMed
  49. von Einem JC, Peter S, Günther C, et al. Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells - TREAT-ME-1 - a phase I, first in human, first in class trial. Oncotarget. 2017; 8(46): 80156–80166.
    CrossRefPubMed
  50. Wang G, Li C, Fan X, et al. Effect of bone marrow mesenchymal stem cells on gas-tric ulcer repairing]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015; 29(7): 889–892.
  51. Whiteford MH. Perianal abscess/fistula disease. Clin Colon Rectal Surg. 2007; 20(2): 102–109.
    CrossRefPubMed
  52. Yoshimura K, Asano Y, Aoi N, et al. Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications. Breast J. 2010; 16(2): 169–175.
    CrossRefPubMed
  53. Zhang D. A clinical study of bone mesenchymal stem cells for the treatment of hepatic fibrosis induced by hepatolenticular degeneration. Genet Mol Res. 2017; 16(1).
    CrossRefPubMed

About cookies

Necessary cookies

Allways active

These cookies are necessary for the proper display and operation of the website. Blocking them may cause the website to malfunction.

Analytical cookies

As part of our website, we use analytical tools, such as Google Analytics, that allow us to verify website traffic. These tools may require the use of cookies.

Community cookies

These are cookies associated with the social networks we use. Accepting them will allow us to associate your visit to the site with our social media profiles.

Marketing cookies

These are cookies responsible for carrying out advertising and marketing activities - consenting to their use will allow us to target you with advertisements based on your previous activities within our website.

Copyright © 2023-2024 Via Medica Regulations Cookie policy Privacy Statement Legal Note