open access

Vol 79, No 2 (2020)
ORIGINAL ARTICLES
Published online: 2019-06-27
Submitted: 2019-04-04
Accepted: 2019-05-24
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Diversity of coronary arterial tree in laboratory mice

D. Kłosińska, B. Ciszek, B. Majchrzak, I. Badurek, A. Ratajska
DOI: 10.5603/FM.a2019.0070
·
Pubmed: 31257564
·
Folia Morphol 2020;79(2):255-264.

open access

Vol 79, No 2 (2020)
ORIGINAL ARTICLES
Published online: 2019-06-27
Submitted: 2019-04-04
Accepted: 2019-05-24

Abstract

Background: Research on the development and topography of mouse coronary arteries has been conducted for many years. Patterns of the course of these vessels have been described in various mouse strains. Our research focused on hearts of MIZZ mice.

Materials and methods: We visualised the coronary artery system by means of latex dye perfusion via the aorta. The injected latex did not reach the capillary vessel system.

Results: The heart of MIZZ mice is supplied with blood by two main coronary arteries: the right and the left one. They deliver blood to the right and left part of the heart, respectively. The right coronary artery arises from the right sinus of the aorta and the left coronary artery from the left sinus. The interventricular septum is usually supplied by the septal artery, which is the main branch of the right coronary artery. All arteries of the coronary system run intramurally. The number of branches and the location of their ostia differed among the examined individuals.

Conclusions: Detailed information about the normal topography of coronary arteries, the number and course of their branches, as well as the area of the heart which is vascularised by these vessels constitutes the basic knowledge necessary to conduct further experiments.

Abstract

Background: Research on the development and topography of mouse coronary arteries has been conducted for many years. Patterns of the course of these vessels have been described in various mouse strains. Our research focused on hearts of MIZZ mice.

Materials and methods: We visualised the coronary artery system by means of latex dye perfusion via the aorta. The injected latex did not reach the capillary vessel system.

Results: The heart of MIZZ mice is supplied with blood by two main coronary arteries: the right and the left one. They deliver blood to the right and left part of the heart, respectively. The right coronary artery arises from the right sinus of the aorta and the left coronary artery from the left sinus. The interventricular septum is usually supplied by the septal artery, which is the main branch of the right coronary artery. All arteries of the coronary system run intramurally. The number of branches and the location of their ostia differed among the examined individuals.

Conclusions: Detailed information about the normal topography of coronary arteries, the number and course of their branches, as well as the area of the heart which is vascularised by these vessels constitutes the basic knowledge necessary to conduct further experiments.

Get Citation

Keywords

coronary artery, heart, septal artery, right coronary artery, mouse

About this article
Title

Diversity of coronary arterial tree in laboratory mice

Journal

Folia Morphologica

Issue

Vol 79, No 2 (2020)

Pages

255-264

Published online

2019-06-27

DOI

10.5603/FM.a2019.0070

Pubmed

31257564

Bibliographic record

Folia Morphol 2020;79(2):255-264.

Keywords

coronary artery
heart
septal artery
right coronary artery
mouse

Authors

D. Kłosińska
B. Ciszek
B. Majchrzak
I. Badurek
A. Ratajska

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