open access

Vol 79, No 1 (2020)
ORIGINAL ARTICLES
Published online: 2019-05-20
Submitted: 2019-03-13
Accepted: 2019-05-14
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Arterial supply of the trigeminal ganglion, a micromorphological study

M. Ćetković, B. V. Štimec, D. Mucić, A. Dožić, D. Ćetković, V. Reçi, S. Çerkezi, D. Ćalasan, M. Milisavljević, S. Bexheti
DOI: 10.5603/FM.a2019.0062
·
Pubmed: 31282551
·
Folia Morphol 2020;79(1):58-64.

open access

Vol 79, No 1 (2020)
ORIGINAL ARTICLES
Published online: 2019-05-20
Submitted: 2019-03-13
Accepted: 2019-05-14

Abstract

Background: In this study, we explored the specific microanatomical properties of the trigeminal ganglion (TG) blood supply and its close neurovascular relationships with the surrounding vessels. Possible clinical implications have been discussed.

Materials and methods: The internal carotid and maxillary arteries of 25 adult and 4 foetal heads were injected with a 10% mixture of India ink and gelatin, and their TGs subsequently underwent microdissection, observation and morphometry under a stereoscopic microscope.

Results: The number of trigeminal arteries varied between 3 and 5 (mean 3.34), originating from 2 or 3 of the following sources: the inferolateral trunk (ILT) (100%), the meningohypophyseal trunk (MHT) (100%), and from the middle meningeal artery (MMA) (92%). In total, the mean diameter of the trigeminal branches was 0.222 mm. The trigeminal branch of the ILT supplied medial and middle parts of the TG, the branch of the MHT supplied the medial part of the TG, and the branch of the MMA supplied the lateral part of the TG. Additional arteries for the TG emerged from the dural vascular plexus and the vascular network of the plexal segment of the trigeminal nerve. Uniform and specific intraganglionicdense capillary network was observed for each sensory trigeminal neuron.

Conclusions: The reported features of the TG vasculature could be implied in a safer setting for surgical approach to the skull base, in relation to the surrounding structures. The morphometric data on TG vasculature provide anatomical basis for better understanding the complex TG blood supply from the internal and external carotid arteries.

Abstract

Background: In this study, we explored the specific microanatomical properties of the trigeminal ganglion (TG) blood supply and its close neurovascular relationships with the surrounding vessels. Possible clinical implications have been discussed.

Materials and methods: The internal carotid and maxillary arteries of 25 adult and 4 foetal heads were injected with a 10% mixture of India ink and gelatin, and their TGs subsequently underwent microdissection, observation and morphometry under a stereoscopic microscope.

Results: The number of trigeminal arteries varied between 3 and 5 (mean 3.34), originating from 2 or 3 of the following sources: the inferolateral trunk (ILT) (100%), the meningohypophyseal trunk (MHT) (100%), and from the middle meningeal artery (MMA) (92%). In total, the mean diameter of the trigeminal branches was 0.222 mm. The trigeminal branch of the ILT supplied medial and middle parts of the TG, the branch of the MHT supplied the medial part of the TG, and the branch of the MMA supplied the lateral part of the TG. Additional arteries for the TG emerged from the dural vascular plexus and the vascular network of the plexal segment of the trigeminal nerve. Uniform and specific intraganglionicdense capillary network was observed for each sensory trigeminal neuron.

Conclusions: The reported features of the TG vasculature could be implied in a safer setting for surgical approach to the skull base, in relation to the surrounding structures. The morphometric data on TG vasculature provide anatomical basis for better understanding the complex TG blood supply from the internal and external carotid arteries.

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Keywords

trigeminal ganglion, trigeminal arteries, inferolateral trunk, meningo-hypophyseal trunk, middle meningeal artery

About this article
Title

Arterial supply of the trigeminal ganglion, a micromorphological study

Journal

Folia Morphologica

Issue

Vol 79, No 1 (2020)

Pages

58-64

Published online

2019-05-20

DOI

10.5603/FM.a2019.0062

Pubmed

31282551

Bibliographic record

Folia Morphol 2020;79(1):58-64.

Keywords

trigeminal ganglion
trigeminal arteries
inferolateral trunk
meningo-hypophyseal trunk
middle meningeal artery

Authors

M. Ćetković
B. V. Štimec
D. Mucić
A. Dožić
D. Ćetković
V. Reçi
S. Çerkezi
D. Ćalasan
M. Milisavljević
S. Bexheti

References (21)
  1. Arsić S, Jovanović I, Petrović A, et al. Stereological analysis of the human fetal trigeminal ganglion microcirculatory bed. Facta Universitatis. 2008; 15(3): 85–91.
  2. Arslan M, Deda H, Avci E, et al. Anatomy of Meckel's cave and the trigeminal ganglion: anatomical landmarks for a safer approach to them. Turk Neurosurg. 2012; 22(3): 317–323.
  3. Bergmann L. Studies on the blood vessels of the human gasserian ganglion. Anat Rec. 1942; 82(4): 609–629.
  4. Burstein R, Jakubowski M, Rauch S. The science of migraine. J Vestib Res. 2011; 21(6): 305–314.
  5. Cetković M, Antunović V, Marinković S, et al. Vasculature and neurovascular relationships of the trigeminal nerve root. Acta Neurochir (Wien). 2011; 153(5): 1051–7; discussion 1057.
  6. de Montes Meana C, Jimenez Castellanos Ballesteros J. Anatomie mesoscopique de l'apport arteriel d'origine meningee pour le ganglion de Gasser. Bull Assoc Anat. 1989; 73: 27–30.
  7. Dožić A, Cetković M, Marinković S, et al. Vascularisation of the geniculate ganglion. Folia Morphol. 2014; 73(4): 414–421.
  8. Hanani M. Satellite glial cells in sensory ganglia: from form to function. Brain Res Brain Res Rev. 2005; 48(3): 457–476.
  9. Harris FS, Rhoton AL. Anatomy of the cavernous sinus. A microsurgical study. J Neurosurg. 1976; 45(2): 169–180.
  10. Krisht A, Barnett DW, Barrow DL, et al. The blood supply of the intracavernous cranial nerves: an anatomic study. Neurosurgery. 1994; 34(2): 275–279;discussion 279.
  11. Lasjaunias P, Moret J, Mink J. The anatomy of the inferolateral trunk (ILT) of the internal carotid artery. Neuroradiology. 1977; 13(4): 215–220.
  12. Lee SH, Hwang SJ, Koh KS, et al. Macroscopic innervation of the dura mater covering the middle cranial fossa in humans correlated to neurovascular headache. Front Neuroanat. 2017; 11: 127.
  13. Lu Q, Harris VA, Rafikov R, et al. Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism. Redox Biol. 2015; 6: 112–121.
  14. Marinković S, Gibo H, Brigante L, Milisavljević M, Donzelli R. Arteries of the Brain and Spinal Cord. Anatomic Features and Clinical Significance. Avelino , De Angelis 1997: 138–142.
  15. Prośba-Mackiewicz M, Zółtowska A, Dziewiatkowski J. Substance-P of neural cells in human trigeminal ganglion. Folia Morphol. 2000; 59(4): 327–331.
  16. Qureshi AI. Artery of trigeminal nerve ganglion. J Vasc Interv Neurol. 2017; 9(6): 57–58.
  17. Robinson DH, Song JK, Eskridge JM. Embolization of meningohypophyseal and inferolateral branches of the cavernous internal carotid artery. AJNR Am J Neuroradiol. 1999; 20(6): 1061–1067.
  18. Smoliar E, Smoliar A, Sorkin L, et al. Microcirculatory bed of the human trigeminal nerve. Anat Rec. 1998; 250(2): 245–249.
  19. Willinsky R, Lasjaunias P, Berenstein A. Intracavernous branches of the internal carotid artery (ICA). Comprehensive review of their variations. Surg Radiol Anat. 1987; 9(3): 201–215.
  20. Yoon N, Shah A, Couldwell WT, et al. Preoperative embolization of skull base meningiomas: current indications, techniques, and pearls for complication avoidance. Neurosurg Focus. 2018; 44(4): E5.
  21. Ziyal IM, Sekhar LN, Ozgen T, et al. The trigeminal nerve and ganglion: an anatomical, histological, and radiological study addressing the transtrigeminal approach. Surg Neurol. 2004; 61(6): 564–73; discussion 573.

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