open access

Vol 75, No 2 (2016)
ORIGINAL ARTICLES
Published online: 2015-11-18
Submitted: 2015-10-04
Accepted: 2015-10-21
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Telocytes of the mammary gland stroma

N. Petre, M. C. Rusu, F. Pop, A. M. Jianu
DOI: 10.5603/FM.a2015.0123
·
Folia Morphol 2016;75(2):224-231.

open access

Vol 75, No 2 (2016)
ORIGINAL ARTICLES
Published online: 2015-11-18
Submitted: 2015-10-04
Accepted: 2015-10-21

Abstract

Although confusions persist in what concerns the terminologies used for describing the fibroblastoid cells of the stromal compartments, the expression of antigens in such cells gradually directs their diagnosis towards a stem/progenitor phenotype. The stromal cells with long, slender and moniliform prolongations were named “telocytes” (TCs), their cell processes being termed “telopodes”. However, the mammary gland TCs were not evaluated for the CD34 expression. Thus an in vivo immunohistochemical study was designed; antibodies against CD10, CD34, CD117/c-kit and vimentin were applied on human mammary gland samples of 8 donor patients. Resident CD34-positive stromal cells positive for the TCs morphology were found building consistent stromal networks and ensheathing microvessels and excretory units. Such cells were CD10±/c-kit-/vimentin+. According to the current concepts regarding the in vivo stem/progenitor cells the CD34+ TCs of the mammary stroma could be actors in the mammary stem niche and their antigens expression could relate to different stages of differentiation.

Abstract

Although confusions persist in what concerns the terminologies used for describing the fibroblastoid cells of the stromal compartments, the expression of antigens in such cells gradually directs their diagnosis towards a stem/progenitor phenotype. The stromal cells with long, slender and moniliform prolongations were named “telocytes” (TCs), their cell processes being termed “telopodes”. However, the mammary gland TCs were not evaluated for the CD34 expression. Thus an in vivo immunohistochemical study was designed; antibodies against CD10, CD34, CD117/c-kit and vimentin were applied on human mammary gland samples of 8 donor patients. Resident CD34-positive stromal cells positive for the TCs morphology were found building consistent stromal networks and ensheathing microvessels and excretory units. Such cells were CD10±/c-kit-/vimentin+. According to the current concepts regarding the in vivo stem/progenitor cells the CD34+ TCs of the mammary stroma could be actors in the mammary stem niche and their antigens expression could relate to different stages of differentiation.

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Keywords

CD34, telocytes, mesenchymal stromal cells, stem cells

About this article
Title

Telocytes of the mammary gland stroma

Journal

Folia Morphologica

Issue

Vol 75, No 2 (2016)

Pages

224-231

Published online

2015-11-18

DOI

10.5603/FM.a2015.0123

Bibliographic record

Folia Morphol 2016;75(2):224-231.

Keywords

CD34
telocytes
mesenchymal stromal cells
stem cells

Authors

N. Petre
M. C. Rusu
F. Pop
A. M. Jianu

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