Folia Morphologica

open access

Vol 74, No 3 (2015)
ORIGINAL ARTICLES
Published online: 2015-09-02
Submitted: 2014-11-03
Accepted: 2014-12-17
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Ameliorative potentials of a combination of fenugreek and alpha-tocopherol on cadmium induced testicular toxicity: an ultrastructural study

A. M. Hussein, H. N. Mustafa, M. H. Badawoud
DOI: 10.5603/FM.2015.0049
·
Pubmed: 26339813
·
Folia Morphol 2015;74(3):325-334.

open access

Vol 74, No 3 (2015)
ORIGINAL ARTICLES
Published online: 2015-09-02
Submitted: 2014-11-03
Accepted: 2014-12-17

Abstract

Background: The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes.

Materials and methods: Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/day of a-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study.

Results: Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and a-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer.

Conclusions: Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.

Abstract

Background: The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes.

Materials and methods: Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/day of a-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study.

Results: Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and a-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer.

Conclusions: Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.

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Keywords

cadmium chloride, fenugreek, a-tocopherol, seminiferous epithelium, ultrastructure

About this article
Title

Ameliorative potentials of a combination of fenugreek and alpha-tocopherol on cadmium induced testicular toxicity: an ultrastructural study

Journal

Folia Morphologica

Issue

Vol 74, No 3 (2015)

Pages

325-334

Published online

2015-09-02

DOI

10.5603/FM.2015.0049

Pubmed

26339813

Bibliographic record

Folia Morphol 2015;74(3):325-334.

Keywords

cadmium chloride
fenugreek
a-tocopherol
seminiferous epithelium
ultrastructure

Authors

A. M. Hussein
H. N. Mustafa
M. H. Badawoud

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