open access

Vol 74, No 1 (2015)
ORIGINAL ARTICLES
Published online: 2015-03-02
Submitted: 2014-08-07
Accepted: 2014-11-06
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Can raisins ameliorate the hypercholesterolaemia-induced cardiac affection?

G. A. Abdel-Hamid, N. N. Ayuob
DOI: 10.5603/FM.2015.0020
·
Pubmed: 25792404
·
Folia Morphol 2015;74(1):106-117.

open access

Vol 74, No 1 (2015)
ORIGINAL ARTICLES
Published online: 2015-03-02
Submitted: 2014-08-07
Accepted: 2014-11-06

Abstract

Raisins were investigated for their protective role on cardiac muscle both biochemically and histopathologically in high cholesterol diet (HCD)-fed rats. Wister male rats were randomly divided into four groups (n = 10): control, raisin-fed, HCD-fed and HCD-raisin fed group. Animals were anaesthetized after 13 weeks. Hearts were dissected and processed for histopathological examination. Raisins administration with HCD significantly decreased the animals’ blood glucose, insulin, cholesterol, triglycerides, and low density lipoprotein levels; while increased their high density lipoprotein levels compared with rats fed HCD alone. They also decreased cardiomyocytes’ degeneration, cellular infiltration, haemorrhages and blood vessels affection. Raisins reduced fibrosis by decreasing the immuno-expression of alpha smooth muscle actin marker, whereas they significantly increased the immuno-expression of endothelial nitric oxide synthase. Raisins showed a cardioprotective effect and were able to alleviate the biochemical and the histopathological changes induced by the HCD. Consumption of raisins or their pharmaceutical product should be recommended specially for those eating a high-fat diet.

Abstract

Raisins were investigated for their protective role on cardiac muscle both biochemically and histopathologically in high cholesterol diet (HCD)-fed rats. Wister male rats were randomly divided into four groups (n = 10): control, raisin-fed, HCD-fed and HCD-raisin fed group. Animals were anaesthetized after 13 weeks. Hearts were dissected and processed for histopathological examination. Raisins administration with HCD significantly decreased the animals’ blood glucose, insulin, cholesterol, triglycerides, and low density lipoprotein levels; while increased their high density lipoprotein levels compared with rats fed HCD alone. They also decreased cardiomyocytes’ degeneration, cellular infiltration, haemorrhages and blood vessels affection. Raisins reduced fibrosis by decreasing the immuno-expression of alpha smooth muscle actin marker, whereas they significantly increased the immuno-expression of endothelial nitric oxide synthase. Raisins showed a cardioprotective effect and were able to alleviate the biochemical and the histopathological changes induced by the HCD. Consumption of raisins or their pharmaceutical product should be recommended specially for those eating a high-fat diet.

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Keywords

hypercholesterolaemia, raisin, cardiomyocytes, immunohistochemistry, actin, eNOS, cardiac muscle protection

About this article
Title

Can raisins ameliorate the hypercholesterolaemia-induced cardiac affection?

Journal

Folia Morphologica

Issue

Vol 74, No 1 (2015)

Pages

106-117

Published online

2015-03-02

DOI

10.5603/FM.2015.0020

Pubmed

25792404

Bibliographic record

Folia Morphol 2015;74(1):106-117.

Keywords

hypercholesterolaemia
raisin
cardiomyocytes
immunohistochemistry
actin
eNOS
cardiac muscle protection

Authors

G. A. Abdel-Hamid
N. N. Ayuob

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