open access

Vol 73, No 4 (2014)
CASE REPORTS
Published online: 2014-11-28
Submitted: 2014-03-31
Accepted: 2014-05-06
Get Citation

Thyroid lymphoepithelial nodule

A. Handra-Luca, E. Dragoescu
DOI: 10.5603/FM.2014.0077
·
Folia Morphol 2014;73(4):507-509.

open access

Vol 73, No 4 (2014)
CASE REPORTS
Published online: 2014-11-28
Submitted: 2014-03-31
Accepted: 2014-05-06

Abstract

Thyroid benign lymphoepithelial lesions are rare in adults, reported as associated with thyroiditis or adjacent to tumours. Here we report a unique case of a thyroid solid nodule with benign lymphoepithelial morphology. A 56-year-old woman presented with a thyroid nodule increasing in size. Thyroid function was normal. On the surgical resection specimen, in addition to a 2-cm follicular adenoma, there was, at distance, a 0.5-cm solid nodule with lymphoepithelial morphology, without Hassal’s corpuscles or calcifications. On immunohistochemistry, the epithelial component was cytokeratin 5/6 positive and very focally cytokeratin 7 positive, the immunophenotype of the lymphoid tissue confirming the benign nature. The diagnosis of thyroid benign lymphoepithelial nodule was proposed. In conclusion, recognition of thyroid solid benign lymphoepithelial nodules is important since they can be misdiagnosed with other thyroid micronodule types including carcinoma, primary or metastatic.

Abstract

Thyroid benign lymphoepithelial lesions are rare in adults, reported as associated with thyroiditis or adjacent to tumours. Here we report a unique case of a thyroid solid nodule with benign lymphoepithelial morphology. A 56-year-old woman presented with a thyroid nodule increasing in size. Thyroid function was normal. On the surgical resection specimen, in addition to a 2-cm follicular adenoma, there was, at distance, a 0.5-cm solid nodule with lymphoepithelial morphology, without Hassal’s corpuscles or calcifications. On immunohistochemistry, the epithelial component was cytokeratin 5/6 positive and very focally cytokeratin 7 positive, the immunophenotype of the lymphoid tissue confirming the benign nature. The diagnosis of thyroid benign lymphoepithelial nodule was proposed. In conclusion, recognition of thyroid solid benign lymphoepithelial nodules is important since they can be misdiagnosed with other thyroid micronodule types including carcinoma, primary or metastatic.

Get Citation

Keywords

lymphoepithelial nodule, micronodule, thyroid

About this article
Title

Thyroid lymphoepithelial nodule

Journal

Folia Morphologica

Issue

Vol 73, No 4 (2014)

Pages

507-509

Published online

2014-11-28

DOI

10.5603/FM.2014.0077

Bibliographic record

Folia Morphol 2014;73(4):507-509.

Keywords

lymphoepithelial nodule
micronodule
thyroid

Authors

A. Handra-Luca
E. Dragoescu

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