open access

Vol 60, No 3 (2001)
ORIGINAL ARTICLES
Published online: 2001-05-29
Submitted: 2012-02-06
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TEM and SEM observations on the extracellular matrix of the developing murine centra

Wilfried Meyer, Martina Ramspott, Ingrid Sauerbier, Hanna Jackowiak, Szymon Godynicki
Folia Morphol 2001;60(3):181-188.

open access

Vol 60, No 3 (2001)
ORIGINAL ARTICLES
Published online: 2001-05-29
Submitted: 2012-02-06

Abstract

TEM and SEM application demonstrated that the shift from chondrification to ossification in the developing murine centra from day 15 to day 18 of gestational age is marked by typical structural variations of the extracellular matrix (ECM). During day 15 GA, typical matrix vesicles with crystalline contents appeared, as followed by single and fusing pleomorphic aggregates of a more regular crystalline structure. During days 17/18 GA, these structures disappeared, and the ECM now exhibited a network of collagen fibrils that had been less conspicuous before. During the time period studied, the ECM switched from a more acid (proteoglycans) to a rather neutral (glycoproteins) milieu.

Abstract

TEM and SEM application demonstrated that the shift from chondrification to ossification in the developing murine centra from day 15 to day 18 of gestational age is marked by typical structural variations of the extracellular matrix (ECM). During day 15 GA, typical matrix vesicles with crystalline contents appeared, as followed by single and fusing pleomorphic aggregates of a more regular crystalline structure. During days 17/18 GA, these structures disappeared, and the ECM now exhibited a network of collagen fibrils that had been less conspicuous before. During the time period studied, the ECM switched from a more acid (proteoglycans) to a rather neutral (glycoproteins) milieu.
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Keywords

development centrum; extracellular matrix; mice; TEM; SEM; ontogenesis; vertebral column

About this article
Title

TEM and SEM observations on the extracellular matrix of the developing murine centra

Journal

Folia Morphologica

Issue

Vol 60, No 3 (2001)

Pages

181-188

Published online

2001-05-29

Bibliographic record

Folia Morphol 2001;60(3):181-188.

Keywords

development centrum
extracellular matrix
mice
TEM
SEM
ontogenesis
vertebral column

Authors

Wilfried Meyer
Martina Ramspott
Ingrid Sauerbier
Hanna Jackowiak
Szymon Godynicki

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